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NCT ID: NCT03525600 Completed - Geographic Atrophy Clinical Trials

Study to Compare the Efficacy and Safety of Intravitreal APL-2 Therapy With Sham Injections in Patients With Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration

Start date: August 31, 2018
Phase: Phase 3
Study type: Interventional

This is a 24-month, Phase III, multicenter, randomized, double-masked, sham-injection controlled study to assess the efficacy and safety of multiple IVT injections of APL-2 in subjects with GA secondary to AMD.

NCT ID: NCT03518034 Completed - Clinical trials for Cardiovascular Diseases

A Study to Evaluate the Effect of Testosterone Replacement Therapy (TRT) on the Incidence of Major Adverse Cardiovascular Events (MACE) and Efficacy Measures in Hypogonadal Men

TRAVERSE
Start date: May 3, 2018
Phase: Phase 4
Study type: Interventional

This is a double-blinded and placebo-controlled study of topical testosterone replacement therapy (TRT) in symptomatic hypogonadal men with pre-existing cardiovascular disease (CVD) or increased risk for CVD.

NCT ID: NCT03512210 Completed - Hepatitis C Clinical Trials

Monitoring SOF/VEL in Treatment Naïve, HCV Participants With Active Infection

MINMON
Start date: October 22, 2018
Phase: Phase 4
Study type: Interventional

To achieve global hepatitis C virus (HCV) elimination by 2030, 80% of the ~71 million people with chronic HCV infection will need to be treated, necessitating simplification of treatment delivery and associated laboratory monitoring without compromising efficacy or safety. The COVID-19 pandemic has further highlighted the need for innovative models of health care delivery that minimize face-to-face patient-provider contact. The purpose of this study was to evaluate the feasibility, safety, and efficacy of a minimal monitoring (MINMON) strategy to deliver interferon- and RBV-free, pan-genotypic DAA therapy to treat active HCV in HCV treatment naïve participants.

NCT ID: NCT03511664 Completed - Prostate Cancer Clinical Trials

Study of 177Lu-PSMA-617 In Metastatic Castrate-Resistant Prostate Cancer

VISION
Start date: May 29, 2018
Phase: Phase 3
Study type: Interventional

The primary objective of this study was to compare the two alternate primary endpoints of radiographic progression-free survival (rPFS) and overall survival (OS) in patients with progressive prostate-specific membrane antigen (PSMA)-positive metastatic castration-resistant prostate cancer (mCRPC) who received 177Lu-PSMA-617 in addition to best supportive/best standard of care (BSC/BSoC) versus patients treated with best supportive/best standard of care alone.

NCT ID: NCT03509467 Completed - Melanoma (Skin) Clinical Trials

Using MC1R Genotype to Impact Melanoma Risk Behavior

Start date: August 3, 2015
Phase: N/A
Study type: Interventional

The purpose of this study is to examine how different messages about risk of melanoma can impact the way people protect themselves against developing these diseases.

NCT ID: NCT03495102 Completed - Clinical trials for Diabetes Mellitus, Type 2

A Study of the Efficacy and Safety of Dulaglutide (LY2189265) in Participants With Type 2 Diabetes

AWARD-11
Start date: April 5, 2018
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the efficacy and safety of investigational doses of once weekly dulaglutide when added to metformin in participants with type 2 diabetes with inadequate blood sugar control.

NCT ID: NCT03482011 Completed - Psoriasis Clinical Trials

A Study to Evaluate the Efficacy and Safety of Mirikizumab (LY3074828) in Participants With Moderate-to-Severe Plaque Psoriasis

OASIS-1
Start date: April 24, 2018
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the efficacy and safety of mirikizumab in participants with moderate to severe plaque psoriasis.

NCT ID: NCT03481634 Completed - Clinical trials for Diabetic Macular Edema

Study of Efficacy and Safety of Brolucizumab vs. Aflibercept in Patients With Visual Impairment Due to Diabetic Macular Edema

KESTREL
Start date: July 23, 2018
Phase: Phase 3
Study type: Interventional

The purpose of this study was to evaluate the efficacy and safety of brolucizumab in treatment of patients with visual impairment due to diabetic macular edema (DME).

NCT ID: NCT03449446 Completed - Clinical trials for Nonalcoholic Steatohepatitis

Study to Evaluate the Safety and Efficacy of Selonsertib, Firsocostat, Cilofexor, and Combinations in Participants With Bridging Fibrosis or Compensated Cirrhosis Due to Nonalcoholic Steatohepatitis (NASH)

ATLAS
Start date: March 21, 2018
Phase: Phase 2
Study type: Interventional

The primary objectives of this study are: - To assess the safety and tolerability of selonsertib (SEL), firsocostat (FIR) and cilofexor (CILO), administered alone or in combination, in participants with bridging fibrosis or compensated cirrhosis due to NASH - To evaluate changes in liver fibrosis, without worsening of NASH

NCT ID: NCT03444038 Completed - Tourette Syndrome Clinical Trials

Open-Label Safety and Tolerability Study of NBI-98854 for the Treatment of Pediatric Subjects With Tourette Syndrome

Start date: February 8, 2018
Phase: Phase 2
Study type: Interventional

This is a Phase 2b, multicenter, open-label study to evaluate the safety and tolerability of optimized doses of NBI-98854 administered once daily for 24 weeks in pediatric subjects with Tourette Syndrome.