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NCT ID: NCT00699998 Completed - Clinical trials for Acute Coronary Syndrome

A Comparison of Prasugrel and Clopidogrel in Acute Coronary Syndrome Subjects

TRILOGY ACS
Start date: June 2008
Phase: Phase 3
Study type: Interventional

This study will evaluate the relative efficacy and safety of prasugrel and clopidogrel in a medically managed Unstable Angina/Non-ST-Elevation Myocardial Infarction (UA/NSTEMI) acute coronary syndrome (ACS) population (that is, patients who are not managed with acute coronary revascularization).

NCT ID: NCT00699374 Terminated - Clinical trials for Carcinoma, Hepatocellular

Study Of Sunitinib Malate Versus Sorafenib In Patients With Inoperable Liver Cancer

Start date: July 2008
Phase: Phase 3
Study type: Interventional

The study will evaluate the efficacy and safety of sunitinib (Arm A), given at 37.5 mg orally once daily, compared to sorafenib (Arm B), given orally at 400 mg twice daily, in patients with inoperable liver cancer. A total number of 1200 patients will be enrolled, 600 on Arm A and 600 on Arm B. Study treatment may be adjusted based on patient tolerance. and will be given until disease progression, occurrence of unacceptable toxicity, or other withdrawal criteria are met. After discontinuation of study treatment, patients will be followed up in order to collect information on further antineoplastic therapy and survival.

NCT ID: NCT00698932 Completed - Type 2 Diabetes Clinical Trials

Evaluate Efficacy and Safety of Saxagliptin in Adult Patients With Type 2 Diabetes Inadequate Glycemic Control

Start date: June 2008
Phase: Phase 3
Study type: Interventional

Saxagliptin is a new investigational medication being developed for treatment of type 2 diabetes. This study is designed to evaluate the efficacy and safety in adult patients with inadequate glycaemic control with diet and exercise.

NCT ID: NCT00697099 Completed - Clinical trials for Venous Thromboembolism

Evaluation of AVE5026 as Compared to Enoxaparin for the Prevention of Thromboembolism in Patients Undergoing Total Hip Replacement Surgery

SAVE-HIP1
Start date: June 2008
Phase: Phase 3
Study type: Interventional

The primary objective was to compare the efficacy of once daily [q.d.] subcutaneous [s.c.] injections of Semuloparin sodium (AVE5026) with q.d. s.c. injections of enoxaparin for the prevention of Venous Thromboembolic Events [VTE] in patients undergoing elective total hip replacement surgery. The secondary objectives were to evaluate the safety of AVE5026 in patients undergoing elective total hip replacement surgery, and to document AVE5026 exposure in this population.

NCT ID: NCT00690638 Completed - Clinical trials for Type 2 Diabetes Mellitus

Safety and Efficacy Study of Dutogliptin/PHX1149T to Treat Type 2 Diabetes Mellitus

Start date: July 2008
Phase: Phase 3
Study type: Interventional

A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multi-Center Study to Evaluate Safety and Efficacy of PHX1149T as Monotherapy in Subjects with Type 2 Diabetes Mellitus

NCT ID: NCT00690456 Terminated - Clinical trials for Diabetes Mellitus, Type 2

Effect of Rimonabant and Metformin Combination on Glycemic Control in Patients With Type 2 Diabetes

TOCCATA
Start date: May 2008
Phase: Phase 3
Study type: Interventional

The primary objective of the study is to determine the effect of rimonabant 20 mg daily when added to ongoing metformin therapy on glycemic control (HbA1c) over a 36 week period in patients with type 2 diabetes. Secondary objectives include evaluation of other markers of glycemic control, lipid profile, body weight, and abdominal obesity. Also, the trial will study the safety of rimonabant when added to metformin over a period of 47 weeks.

NCT ID: NCT00687492 Completed - Clinical trials for Hypercholesterolemia

Centralized Pan-Asian Survey on the Under Treatment of Hypercholesterolemia

CEPHEUS
Start date: May 2008
Phase: N/A
Study type: Observational

The survey will try to establish the proportion of patients on lipid-lowering pharmacological treatment reaching the LDL-C goals according to the third NCEP ATP guidelines, overall and by country.

NCT ID: NCT00685360 Completed - Clinical trials for Tuberculosis, Pulmonary

A Trial to Evaluate OPC 67683 in Participants With Pulmonary Sputum Culture-positive, Multidrug-resistant Tuberculosis (TB)

Start date: May 8, 2008
Phase: Phase 2
Study type: Interventional

This is a clinical trial to evaluate the safety and efficacy of OPC-67683 in the treatment of multidrug resistant tuberculosis (MDR TB) for 56 days. In addition to an optimized background regimen (OBR), participants will be randomized to receive: - 100 mg OPC-67683 twice daily (BID) - 200 mg OPC-67683 BID - Placebo BID After 56 days participants will complete their optimized background regimen (OBR).

NCT ID: NCT00683878 Completed - Type 2 Diabetes Clinical Trials

Add-on to Thiazolidinedione (TZD) Failures

Start date: July 2008
Phase: Phase 3
Study type: Interventional

The purpose of this clinical research study is to learn if BMS-512148 (Dapagliflozin) can help reduce the blood sugar levels in subjects with Type 2 Diabetes who are not well controlled on TZD alone. The safety of this treatment will also be studied

NCT ID: NCT00683657 Completed - Type 2 Diabetes Clinical Trials

Safety and Efficacy Study of Subjects That Are Taking Saxagliptin Added Onto Metformin XR Compared to Subjects Taking Metformin XR Alone

Start date: July 2008
Phase: Phase 3
Study type: Interventional

This protocol will compare 24 hour glucose control for subject taking saxagliptin and metformin extended release (XR) versus metformin XR alone