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NCT ID: NCT00880269 Completed - Clinical trials for Acute Myelogenous Leukemia

Efficacy and Safety of Panobinostat (LBH5789) in Patients With Refractory de Novo or Secondary Acute Myelogenous Leukemia (AML)

Start date: August 2009
Phase: Phase 2
Study type: Interventional

This study will evaluate the efficacy and safety of single agent oral panobinostat in patients who have refractory de novo or refractory secondary AML.

NCT ID: NCT00879970 Terminated - Clinical trials for Diabetes Mellitus, Type 2

Thiazolidinedione Intervention With Vitamin D Evaluation

TIDE
Start date: May 2009
Phase: Phase 4
Study type: Interventional

This study will answer two separate questions. The first question is to test the cardiovascular effects of long-term treatment with rosiglitazone or pioglitazone when used as part of standard of care compared to similar standard of care without rosiglitazone or pioglitazone in patients with type 2 diabetes who have a history of or are at risk for cardiovascular disease. The second question will compare the effects of long-term supplementation of vitamin D on death and cancer

NCT ID: NCT00879333 Completed - Clinical trials for Advanced Gastric Cancer

Safety and Efficacy of RAD001 (Everolimus) Monotherapy Plus Best Supportive Care in Patients With Advanced Gastric Cancer (AGC)

GRANITE-1
Start date: July 2009
Phase: Phase 3
Study type: Interventional

This study is designed to assess the safety and efficacy of RAD001 monotherapy in patients with advanced gastric cancer which has progressed after one or two lines of prior chemotherapy.

NCT ID: NCT00878709 Completed - Breast Cancer Clinical Trials

Study Evaluating The Effects Of Neratinib After Adjuvant Trastuzumab In Women With Early Stage Breast Cancer

ExteNET
Start date: July 9, 2009
Phase: Phase 3
Study type: Interventional

The purpose of this study is to investigate whether neratinib can further reduce the risk of recurrence from previously diagnosed HER-2 positive breast cancer after adjuvant treatment with trastuzumab.

NCT ID: NCT00877006 Completed - Clinical trials for Non-Hodgkin's Lymphoma

Study of Bendamustine Hydrochloride and Rituximab (BR) Compared With R-CVP or R-CHOP in the First-Line Treatment of Patients With Advanced Indolent Non-Hodgkin's Lymphoma (NHL) or Mantle Cell Lymphoma (MCL) - Referred to as the BRIGHT Study

Start date: April 30, 2009
Phase: Phase 3
Study type: Interventional

The primary objective of the study is to compare the complete response (CR) rate of bendamustine and rituximab (BR) with that of standard treatment regimens of either rituximab, cyclophosphamide, vincristine, and prednisone (R-CVP) or rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) in patients with advanced, indolent non-Hodgkin's lymphoma (NHL) or mantle cell lymphoma (MCL).

NCT ID: NCT00876798 Completed - Clinical trials for Euvolemic Hyponatremia

A Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Tolerability of Oral Lixivaptan Capsules in Subjects With Euvolemic Hyponatremia

Start date: June 2009
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the safety and tolerability of oral lixivaptan capsules in subjects with Euvolemic Hyponatremia.

NCT ID: NCT00876395 Completed - Breast Cancer Clinical Trials

Everolimus in Combination With Trastuzumab and Paclitaxel in the Treatment of HER2 Positive Locally Advanced or Metastatic Breast Cancer

BOLERO-1
Start date: September 10, 2009
Phase: Phase 3
Study type: Interventional

The purpose of this Phase III study was to confirm the value of adding everolimus to weekly paclitaxel and trastuzumab as treatment of HER2-overexpressing metastatic breast cancer.

NCT ID: NCT00876317 Terminated - Clinical trials for Tenosynovitis and Bursitis Affecting the Shoulder

Etoricoxib in Acute Soft Tissue Rheumatism Affecting the Shoulder

Start date: November 2009
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the efficacy and safety two oral doses of etoricoxib (60 mg and 90 mg) daily in acute soft tissue rheumatism affecting the shoulder.

NCT ID: NCT00868959 Completed - Bipolar Depression Clinical Trials

Lurasidone - A 24-week Extension Study of Patients With Bipolar I Depression

Start date: April 2009
Phase: Phase 3
Study type: Interventional

This clinical study is designed to test the hypothesis that lurasidone is effective, tolerable, and safe for the treatment of patients with bipolar I depression

NCT ID: NCT00867048 Completed - HIV Infection Clinical Trials

Strategic Timing of Antiretroviral Treatment

START
Start date: April 15, 2009
Phase: Phase 4
Study type: Interventional

Objectives: - To find out if the chance of developing a serious illness or of getting AIDS is less if patients start taking HIV medicines at a time when their cluster-of-differentiation-4 (CD4)+ cell count is still fairly high, instead of waiting until the CD4+ count is at the level where there is good evidence for starting medicines. - To learn more about how a strategy of starting HIV medicines early might affect other aspects of care, such as the chances of developing other illnesses or resistance to HIV medicines, the frequency of doctor visits, the cost of medical care, and general health and satisfaction.