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NCT ID: NCT00252005 Completed - Clinical trials for Deep-Vein Thrombosis

Oral Direct Factor Xa-inhibitor Apixaban in Patients With Acute Symptomatic Deep-vein Thrombosis-The Botticelli DVT Study

Start date: November 2005
Phase: Phase 2
Study type: Interventional

The purpose of this clinical research study is to assess efficacy and safety of 3 doses of apixaban 5 mg twice a day, 10 mg twice a day and 20 mg once daily versus conventional treatment with low molecular weight heparin or fondaparinux and vitamin K antagonist in the treatment of subjects with acute symptomatic deep-vein thrombosis.

NCT ID: NCT00251979 Completed - Clinical trials for Gastrointestinal Hemorrhage

A Study to Prevent Rebleeding After Initial Successful Primary Endoscopic Haemostasis of a Bleeding Peptic Ulcer

Start date: October 2005
Phase: Phase 3
Study type: Interventional

This study is being carried out to see if constant 3 days infusion of Nexium is effective in preventing rebleeding after an endoscopic treatment.

NCT ID: NCT00251927 Completed - Clinical trials for Gastroesophageal Reflux

Esomeprazole (NEXIUM) vs. Surgery

LOTUS
Start date: October 2001
Phase: Phase 3
Study type: Interventional

The study investigates the efficacy of long-term treatment of esomeprazole compared to anti-reflux surgery in the control of gastroesophageal reflux disease by assessing time to treatment failure.

NCT ID: NCT00251901 Completed - Chest Pain Clinical Trials

Chest Pain Pilot Study

Start date: May 2004
Phase: Phase 3
Study type: Interventional

The purpose of this study is to compare the efficacy of Nexium® with placebo in relief of acid related pain or discomfort in the chest.

NCT ID: NCT00251251 Completed - Clinical trials for Heart Failure, Congestive

Resynchronization/Defibrillation for Ambulatory Heart Failure Trial

RAFT
Start date: April 2003
Phase: N/A
Study type: Interventional

Congestive heart failure (CHF) is a common health problem that leads to frequent hospitalizations and an increased death rate. In spite of advances in drug therapy, it remains a significant public health problem. Recently, a new therapy has been developed for advanced heart failure patients with a ventricular conduction abnormality. This new therapy, called cardiac resynchronization (CRT), is a device which stimulates the atrium, the right ventricle, and the left ventricle providing synchronization of the contraction of the heart chambers. It is the addition of this therapy to an implantable cardioverter defibrillator (ICD) that will be evaluated in this study. This study will compare whether the implantation of this new therapy device, in combination with an implantable cardioverter defibrillator, will reduce total mortality and hospitalizations for CHF.

NCT ID: NCT00251238 Completed - Raynaud Disease Clinical Trials

Efficacy and Tolerability of Ginkgo Biloba Extract in Patients With Raynaud´s Phenomenon

Start date: November 2005
Phase: Phase 2
Study type: Interventional

The aim of the study is to investigate the efficacy and safety of EGb 761® in patients with the primary Raynaud phenomenon, with regards to the frequency, duration and severity of vasospastic attacks.

NCT ID: NCT00251199 Completed - Hepatitis C Clinical Trials

VX-950 and Peginterferon for Hepatitis C

Start date: October 2005
Phase: Phase 1
Study type: Interventional

VX-950 is an investigational drug , which is being tested in combination with a known treatment for hepatitis C, peginterferon.

NCT ID: NCT00250939 Completed - Clinical trials for Pompe Disease (Late-onset)

A Study of rhGAA in Patients With Late-Onset Pompe Disease

Start date: February 2005
Phase: Phase 2
Study type: Interventional

Pompe disease (also known as glycogen storage disease Type II) is caused by a deficiency of a critical enzyme in the body called acid alpha-glucosidase (GAA). Normally, GAA is used by the body's cells to break down glycogen (a stored form of sugar) within specialized structures called lysosomes. In patients with Pompe disease, an excessive amount of glycogen accumulates and is stored in various tissues, especially heart and skeletal muscle, which prevents their normal function. The overall objective is to evaluate the safety, pharmacokinetics (PK) and efficacy of Myozyme treatment.

NCT ID: NCT00250250 Completed - Turner's Syndrome Clinical Trials

An Open-Label, Multi-centre, Phase III Study of Local Tolerability of ZOMACTON 10MG

Start date: October 2005
Phase: Phase 3
Study type: Interventional

Children with growth failure due to inadequate secretion of growth hormone or growth retardation due to Turner's syndrome are individually dosed and treated for 12 weeks

NCT ID: NCT00250237 Completed - Hip Fracture Clinical Trials

Post-operative Haloperidol Versus Placebo for Prevention of Post-operative Delirium After Acute Hip Surgery

Start date: November 2005
Phase: Phase 3
Study type: Interventional

In this study the investigators want to determine if treatment with haloperidol direct post-operatively after acute hip surgery in high risk patients protects against developing a post-operative delirium.