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NCT ID: NCT03703947 Recruiting - Clinical trials for Abdominal Aortic Aneurysm

Biomarker Profiling in Abdominal Aortic Aneurysm Patients

Start date: March 23, 2017
Study type: Observational

The BIOMArCS-AAA study aims to investigate the associations of (temporal patterns of) blood biomarkers with aneurysm growth in patients with abdominal aortic aneurysm (AAA), with particular attention to biomarkers that have demonstrated prognostic value for adverse disease outcomes in coronary artery disease and biomarkers for the main genetic pathways associated with AAA.

NCT ID: NCT03703297 Recruiting - Clinical trials for Small Cell Lung Cancer

Study of Durvalumab + Tremelimumab, Durvalumab, and Placebo in Stage I-III Limited Disease Small-Cell Lung Cancer in Patients Who Have Not Progressed Following Concurrent Chemoradiation Therapy

Start date: September 27, 2018
Phase: Phase 3
Study type: Interventional

This is a Phase III, Randomized, Double-blind, Placebo-controlled, Multi-center, International Study of Durvalumab or Durvalumab and Tremelimumab as Consolidation Treatment for Patients with Stage I-III LD-SCLC Who Have Not Progressed Following Concurrent Chemoradiation Therapy

NCT ID: NCT03702530 Not yet recruiting - Clinical trials for Necator Americanus Infection

Immunisation, Treatment and Controlled Human Hookworm Infection

Start date: March 2019
Phase: N/A
Study type: Interventional

24 healthy volunteers will be immunized with three times 50 L3 larvae or placebo followed by treatment with albendazol and subsequently challenged with twice 50 L3 larvae.

NCT ID: NCT03698435 Recruiting - Clinical trials for Cytomegalovirus Infections

(Val)Ganciclovir TDM in Transplant Recipients

Start date: May 25, 2018
Study type: Observational

The aim of this study is to gain more insight into therapeutic drug monitoring and thus the pharmacodynamics and pharmacokinetics of ganciclovir, in the context of prophylaxis and treatment of CMV infections, in order to provide the patient with an adequate dose.

NCT ID: NCT03697798 Recruiting - Pertussis Clinical Trials

A Study Exploring Whooping Cough Protection in Children and Adults

Start date: April 18, 2018
Phase: Phase 4
Study type: Interventional

This study aims to investigate the effects of aP booster vaccination in children, young adults and elderly on the (long-term) immune response to B. pertussis in three European countries with a different epidemiological background and primary vaccination schedule for pertussis.

NCT ID: NCT03697707 Recruiting - Clinical trials for Acute Myeloid Leukemia in Remission

Efficacy and Safety of Immunotherapy With Allogeneic Dendritic Cells, DCP-001, in Patients With Acute Myeloid Leukaemia

Start date: October 2018
Phase: Phase 2
Study type: Interventional

Phase II study to evaluate safety and efficacy of DCP-001 in patients with AML in CR, and with presence of MRD

NCT ID: NCT03696836 Not yet recruiting - Clinical trials for Osteo Arthritis Knee

AIR (Artificial Implant for Medial Meniscus Replacement) Study

Start date: October 11, 2018
Phase: N/A
Study type: Interventional

The AIR Study is a multi-center, prospective, interventional clinical trial with the objective to evaluate the safety and performance of the Trammpolin® meniscus prosthesis system.

NCT ID: NCT03695094 Recruiting - Epilepsy Clinical Trials

A Study in Participants With Epilepsy, to Evaluate the Pharmacokinetics, Safety and Tolerability of Oxcarbazepine on Padsevonil

Start date: September 18, 2018
Phase: Phase 1
Study type: Interventional

The purpose of the study is to evaluate the effect of stable coadministered oxcarbazepine (OXC), on the pharmacokinetics (PK), safety, tolerability of padsevonil (PSL) and the plasma PK of PSL metabolites, UCB1431322-000 and UCB1447499-000, in study participants with epilepsy compared with study participants co-medicated with stable doses of levetiracetam (LEV), lamotrigine (LTG) or brivaracetam (BRV) therapy.

NCT ID: NCT03694210 Not yet recruiting - Acute Pancreatitis Clinical Trials

EndoRotor DEN (Direct Endoscopic Necrosectomy)Trial

Start date: October 25, 2018
Phase: N/A
Study type: Interventional

A prospective, single arm, open label, multi-center, trial to evaluate the safety and effectiveness of the Interscope EndoRotor® Resection System in subjects requiring direct endoscopic necrosectomy (DEN) with walled off pancreatic necrosis (WOPN).

NCT ID: NCT03693573 Not yet recruiting - Clinical trials for Renal Cell Carcinoma

A Study of Atezolizumab in Combination With Bevacizumab in Untreated Locally Advanced or Metastatic Clear Cell or Non-Clear Cell Renal Cell Carcinoma

Start date: January 11, 2019
Phase: Phase 3
Study type: Interventional

Study MO39939 is an open-label, single-arm, multicenter trial in patients with unresectable, locally-advanced or metastatic, clear or non-clear cell renal cell carcinoma (RCC) who have not received prior systemic therapy (who are treatment naïve in either the [neo]adjuvant or advanced/metastatic setting for clear and non-clear cell RCC). The study consists of a Screening Period, a Treatment Period, an End of Treatment Visit occurring approximately 30 days after the last dose of study medication, and a Follow-Up Period of 4 years after last patient enrolled.