There are about 2118 clinical studies being (or have been) conducted in Malaysia. The country of the clinical trial is determined by the location of where the clinical research is being studied. Most studies are often held in multiple locations & countries.
Procedures: The study will be conducted in two phases: Phase 1 - Perception and Satisfaction questionnaire will be developed - A validation test will be conducted on the Perception and Satisfaction questionnaire (face, content and construct) before conducting the study. The validation process will involve the participation of lecturers, professors and students by convenience sampling. Phase 2 - To prevent bias from the researchers, each participant will be given their code as their identification number. Then the participants will be randomly divided into two groups. They will be briefed on the purpose of study (stating that, the investigators would like to see the efficacy of various teaching methods on students' knowledge gain) and procedure of the study (examinations will be conducted, surveys at the end of each class session and at the end of the study). They are requested to fill up basic demographic data, consent form and ILS questionnaire(measuring the learning style of student) before beginning the study. - In this study, the lecture will be given by the 'Researcher 1' to standardize the input to the participants of the two groups. This will produce a standardized input to the students of the two groups of teaching method. - For the FC (flipped classroom) group, the length of the pre-recorded lecture videos will be the same which the participants can view it unlimitedly. An assignment will be given for FC group that will be attempted during the discussion class(2 hours) a week after with the lecturer. No grades will be given for the assignment. - Meanwhile for the TC(traditional classroom) group, a standard lecture class of 1 hour and 1 hour of tutorial class will be conducted on the same topic. The same ungraded assignment will also be given to this group a week after the lecture class to be attempted in the tutorial class - One day gap will be given following the discussion and tutorial class for FC and TC groups respectively following which an examination of 1 hour duration will be conducted to test on their level of knowledge (assessed by exam score) on the topic being taught for both the groups using the same set of questions. - At the end of the study, each participant will be given a feedback questionnaire to evaluate their perception and satisfaction on the teaching method applied on them using the 'Perception and Satisfaction Questionnaire'.
This study will evaluate the efficacy, safety, tolerability, and effect on quality of life of oral capecitabine in combination with intravenous (IV) cisplatin in participants with metastatic nasopharyngeal cancer. Participants will receive up to 8 cycles of capecitabine treatment, and cisplatin will be administered on the first day of each cycle. The anticipated time on study treatment is up to 24 weeks, and the target sample size is 44 individuals.
This is a Phase 3, double-blind, randomized, placebo-controlled, multicenter study to determine the efficacy and safety of luspatercept (ACE-536) plus Best supportive care (BSC) versus placebo plus BSC in adults who require regular red blood cell transfusion due to (β)-thalassemia. The study is divided into the following periods: - Historical Period, - Screening/Run-in Period, - Double-blind Treatment Period (48 weeks), - Double-blind Long-term Treatment Period, (at the investigator's discretion an additional 48 weeks), - Open-Label Phase post unblinding and upon Data Monitoring Committee positive recommendation - Post-treatment Follow-up Period
to investigate effectiveness and safety of afatinib in the advanced NSCLC patients with HER2 mutations, previously treated with 1 or 2 chemotherapy regimens
Systemic Sclerosis (SSc) is a devastating disease of unknown etiology. Patients suffer from multiple organ fibrosis whereas lung fibrosis (interstitial lung disease, ILD) is one of the main driver for mortality. There is preclinical evidence for efficacy of nintedanib in SSc and associated ILD (SSc-ILD) and the anti-fibrotic efficacy of nintedanib was proven in idiopathic pulmonary fibrosis patients, who are presenting a similar pattern regarding lung fibrosis. Hence it is the purpose of the trial to confirm the efficacy and safety of nintedanib 150 mg bid in treating patients with SSc-ILD, compared with placebo. The trial will be conducted as a double blind, randomised, placebo-controlled trial with primary efficacy evaluation at week 52 and placebo-controlled treatment until last patient out (up to a maximum of 100 weeks). Respiratory function is globally accepted for assessment of treatment effects in patients with lung fibrosis. The chosen endpoint (Forced Vital Capacity (FVC) decline) is easy to obtain and is part of the usual examinations done in patients with SSc-ILD.
RE-COVERY is a large, multi-national, multi-center observational study based on new data collection. The study will enroll and characterize patients within 30 days of being diagnosed with an acute DVT and/or PE. The study has two main objectives. Objective 1 will characterize the DVT / PE patient population. All patients with a DVT and/or PE will be enrolled for cross-sectional characterization of the VTE patient population. Objective 2 will compare the safety and effectiveness of dabigatran etexilate regimens for treatment of VTE in comparison to VKA regimens. Patients treated with dabigatran etexilate or VKA will be followed up for the occurrence of outcome events for up to one year.
The purpose of this study is to assess the tolerability, safety, and efficacy of bupropion hydrochloride sustained-release in the treatment of sexual dysfunction in men on methadone maintenance therapy.
General objective: To assess the performance and safety profile of a novel innovative design of female condom (Wondaleaf®) among healthy married women. Specific objectives : - To determine the failure rate of Wondaleaf®, in terms of clinical breakage, non-clinical breakage, invagination, misdirection, and slippage. - To determine the acceptability and satisfaction of use of Wondaleaf® by subjects and their spouses. - To assess the safety profile of Wondaleaf®.
The objectives of the study are to assess the safety, tolerability, preliminary efficacy and PK of multiple subcutaneous (SC) doses of pegcetacoplan in subjects with paroxysmal nocturnal hemoglobinuria (PNH) who have not received treatment with eculizumab in the past. An exploratory objective of the study is to assess the pharmacodynamics (PD) of multiple SC doses of pegcetacoplan when administered to PNH patients.
A Phase III, Randomized, Observer-Blind, Controlled, Multicenter Clinical Study to Evaluate the Efficacy, Safety and Immunogenicity of an MF59-Adjuvanted Quadrivalent Influenza Vaccine Compared to Non-influenza Vaccine Comparator in Adults ≥ 65 Years of Age.