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NCT ID: NCT03955094 Not yet recruiting - Clinical trials for Pediatric Endotracheal Intubation

Ambu® Auragain™ as a Conduit for Intubation in Paediatrics

Start date: June 1, 2019
Phase: N/A
Study type: Interventional

This study will be conducted as a prospective observational study This study will be done in any of the operating theatres of University Malaya Medical Centre This study will involve paediatric cases ( ages 3-12 years )posted for elective operations which require general anaesthesia with endotracheal intubation Ambu Aura Gain will be used as a conduit for intubation

NCT ID: NCT03952260 Not yet recruiting - Clinical trials for Clear Fluid Fasting Protocol Prior to Paediatric Anaesthesia

Feasibility of 1 Hour Clear Fluid Fasting Prior to Paediatric GA

Start date: May 15, 2019
Phase: N/A
Study type: Interventional

The study is aim to provide to investigate the appropriate fasting time for clear fluid in paediatric patients who planned for elective minor surgery. This is important because we need to determine the gastric residual volume for paediatric age group prior to elective minor surgery, whether the difference between 1 hour fasting and 2 hour fasting for clear fluid is significant. This is a randomize control trial, which patient will be selected randomly to fast for clear fluid for 2 hours or 1 hour.

NCT ID: NCT03944655 Recruiting - Sore Throat Clinical Trials

Does Strepsils® With Lignocaine Lozenges Reduce Post Operative Sore Throat Due To Supraglottic Airway Devices

POSTrepsils
Start date: January 17, 2019
Phase: N/A
Study type: Interventional

The primary objective of this study is to assess the effect of preoperative administration of oral Strepsils® with added Lignocaine lozenges on the incidence of postoperative sore throat (POST) after general anaesthesia using a Supraglottic Airway Device (SAD). Patients undergoing surgery with general anaesthesia will require ventilation of their lungs with either a flexible tube placed beyond the voice box called an endotracheal tube (ETT) or a tube placed above the voice box called a Supraglottic Airway Device. This tube helps oxygenate the patient and delivers anaesthetic gas to the lungs. The procedure is invasive and uncomfortable, and one of the most common complaints is a sore and inflamed throat after the tube is taken out. This is termed postoperative sore throat (POST). The incidence of POST after SAD is comparable with the ETT and though many studies have focused on ETT, few have examined the SAD. After written informed consent is received in pre-op, a sealed and coded envelope with either the Strepsils lozenges or the placebo lozenges will be given to the patient to be administered orally, with the instruction to dissolve the lozenge by sucking on it 45 minutes prior to surgery. Upon completion of surgery and emergence from general anaesthesia, the patient will be assessed regarding the incidence and severity of sore throat, difficulty in swallowing and difficulty in speaking by the investigator using an interview format. The severity of these symptoms will be graded on a 4-point scale ranging from 0 to 3; 0 being no symptoms, 1 being mild symptoms, 2 being moderate symptoms, and 3 being severe symptoms. This evaluation will be performed at 30 minutes and 24 hours post removal of SAD.

NCT ID: NCT03941886 Not yet recruiting - Pre-Eclampsia Clinical Trials

Implementation of First-trimester Screening and preventiOn of pREeClAmpSia Trial (FORECAST)

FORECAST
Start date: June 2019
Phase: N/A
Study type: Interventional

This implementation study aims to evaluate the efficacy, acceptability, and safety of first-trimester screening and prevention for preterm-preeclampsia. It is a multicenter stepped wedge cluster randomized trial including maternity / diagnostic units from ten regions in Asia. The study involves a period where no intervention will take place at all recruiting units, and then at regular intervals, one cluster will be randomized to transit from non-intervention group to intervention group in which first-trimester screening for preterm-preeclampsia by the Bayes based method followed by the commencement of low-dose aspirin in high-risk women.

NCT ID: NCT03940612 Recruiting - Vaginal Diseases Clinical Trials

Probiotic for Vaginal Candidiasis in Pregnant Women

Start date: May 1, 2019
Phase: N/A
Study type: Interventional

This project aims to study the benefits of a probiotic product, STP4 for vaginal health properties, primarily prevention of vaginal candidiasis, among pregnant women in second and third trimester pregnancy.

NCT ID: NCT03937544 Recruiting - Clinical trials for Relapsed B Acute Lymphoblastic Leukaemia

Intravenous Autologous CD19 CAR-T Cells for R/R B-ALL

Start date: March 19, 2019
Phase: Phase 2/Phase 3
Study type: Interventional

This is Phase II / III, Prospective, single arm, Open Label Study to Evaluate Safety and Efficacy of Intravenous Autologous CD19 CAR-T Cells for Relapsed / Refractory B-Acute Lymphoblastic Leukaemia

NCT ID: NCT03932682 Not yet recruiting - Influenza, Human Clinical Trials

Efficacy Study With QIVc in Pediatric Subjects

Start date: April 29, 2019
Phase: Phase 3
Study type: Interventional

This phase 3 clinical study is a randomized, observer-blind, multicenter study of QIVc versus a non-influenza vaccine in subjects 6 months though 47 months of age. The purpose of this study is to evaluate efficacy of QIVc in the prevention of Reverse transcription polymerase chain reaction (RT-PCR) confirmed influenza A or B disease in children 6 through 47 months of age, compared to a non-influenza vaccine.

NCT ID: NCT03930901 Completed - Clinical trials for Knowledge, Attitudes, Practice

Impact of Health Education Learning Package Against Intestinal Parasitic Infections Among Orang Asli Children

Start date: April 18, 2017
Phase: N/A
Study type: Interventional

A health education learning package (HELP) has been improved and evaluated for its impact against intestinal parasitic infections among Orang Asli schoolchildren in West Malaysia. 13 schools were allocated into two groups (intervention and control groups) and the impact of HELP was evaluated after 3 and 6 months of baseline assessment and HELP intervention.

NCT ID: NCT03924726 Completed - Orthodontics Clinical Trials

Osseous Evidence Behind Micro-osteoperforation in Accelerating Tooth Movement.

Start date: May 10, 2017
Phase: N/A
Study type: Interventional

Introduction The study aimed to investigate the effects of micro-osteoperforations (MOPs) on the changes in mandibular bone volume fraction (Bone Volume/Total Volume, BV/TV), in relation to the MOP effects on the rate of orthodontic tooth movement, using CBCT images. The other objective was to evaluate the effects of different frequency intervals (4 weeks, 8 weeks and 12 weeks) of MOPs on mandibular bone volume fraction (BV/TV), in relation to the rate of tooth movement. Methods In 24 participants, orthodontic force of 140-200 grams was applied for mandibular canine retraction. Three micro-osteoperforations (MOP's) were made according to the scheduled intervals of the three different groups (4, 8 and 12 weeks) directly at the mandibular buccal cortical bone of extracted first premolars sites. At the 12th week following MOP application, CBCT scans were performed. CT Analyser software was used to compute trabecular alveolar bone volume fraction (BV/TV).

NCT ID: NCT03912935 Recruiting - Clinical trials for Endotracheal Intubation in Bed up Head Elevation Position in Rapid Sequence Induction

Comparison of Bed up Head Elevated Position With Sniffing Position in Rapid Sequence Induction.

Start date: August 24, 2018
Phase: N/A
Study type: Interventional

This study is aimed to conduct a randomised controlled trial comparing endotracheal intubation (ETI) in bed up head elevation BUHE position versus sniffing position in simulated rapid sequence induction (RSI). Objective is to determine if the time taken for intubation in the bed up head elevated position is non-inferior to time taken for intubation in the sniffing position. The hypotheses: 1. In patients undergoing rapid sequence induction in simulated emergency surgery under general anaesthesia, direct laryngoscopy (DL) and ETI in the BUHE position is non inferior to time required for DL and successful ETI in the sniffing position. 2. In patients undergoing rapid sequence induction in simulated emergency surgery under general anaesthesia, direct laryngoscopy (DL) and ETI in the BUHE position improve POGO score. 3. In patients undergoing rapid sequence induction in simulated emergency surgery under general anaesthesia, direct laryngoscopy (DL) and ETI in the BUHE position reduces airway related complications. Terminology: Direct laryngoscopy (DL) and Endotracheal intubation (ETI): Is a method of inserting a breathing tube into the trachea (windpipe) once patient undergo general anaesthesia. Bed up head elevation (BUHE): Bed up at 20-30 degree aiming alignment between the external auditory meatus with sternal notch. Sniffing position: Maintaining supine position with head elevation with head rest. Rapid sequence induction (RSI): An established method of inducing anaesthesia in patients who are at risk of aspiration of gastric contents into the lungs. It involves loss of consciousness during cricoid pressure followed by intubation without face mask ventilation. The aim is to intubate the trachea as quickly and as safely as possible. POGO score: Percentage of glottic opening Cricoid Pressure (CP): Maneuvre to prevent regurgitation of gastric contents during induction of anaesthesia by temporary occlusion of the upper end of the esophagus by backward pressure of cricoid cartilage against bodies of cervical vertebrae.