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NCT ID: NCT01199081 Completed - Atrial Fibrillation Clinical Trials

Pharmacokinetics and Optimal Timing of Dronedarone Initiation Following Long-term Amiodarone in Patients With Paroxysmal or Persistent Atrial Fibrillation

ARTEMIS AF LT
Start date: October 2010
Phase: Phase 4
Study type: Interventional

Primary Objective: - Explore Dronedarone and active metabolite pharmacokinetic (PK) profiles according to different timings of Dronedarone initiation. Secondary Objective: - Explore potential PK interaction between Dronedarone and Amiodarone - Evaluate the rate of Atrial Fibrillation (AF) recurrence during the study period (from randomization up to 60 days after) - To assess the safety of the change from Amiodarone to Dronedarone and Dronedarone safety

NCT ID: NCT01198756 Completed - Influenza Clinical Trials

A Study to Evaluate the Safety and Immunogenicity of GSK Biologicals' Seasonal Influenza Vaccine in Children

Start date: October 1, 2010
Phase: Phase 3
Study type: Interventional

This study is designed to test the immunogenicity and safety of an investigational influenza vaccine, in children compared to two other influenza vaccines.

NCT ID: NCT01198002 Terminated - Clinical trials for Rheumatoid Arthritis

A Rheumatoid Arthritis Study in Participants on a Background Treatment of Methotrexate

FLEX M
Start date: December 2010
Phase: Phase 3
Study type: Interventional

The primary purpose of this study is to help answer if LY2127399 is safe and effective in the treatment of rheumatoid arthritis while on a background treatment of methotrexate. This study is comprised of 3 periods: Period 1: 52-week blinded treatment Period 2: additional 48-week unblinded treatment Period 3: 48-week post-treatment follow-up

NCT ID: NCT01197794 Completed - Asthma Patients Clinical Trials

Investigation of Efficacy, Safety and Tolerability of Once and Twice Daily Doses of AZD1981 in Asthmatic Patients

Sweapea
Start date: October 2010
Phase: Phase 2
Study type: Interventional

The study will assess the efficacy, safety and tolerability of AZD1981 compared to non-active compound in asthmatic patients.

NCT ID: NCT01197755 Completed - Clinical trials for Rheumatoid Arthritis

Evaluation of Effectiveness of Two Dosing Regimens of Fostamatinib Compared to Placebo in Patients With Rheumatoid Arthritis (RA) Who Are Taking Methotrexate and Have Had Inadequate Response to Single TNF-alpha Antagonist

OSKIRA - 3
Start date: September 2010
Phase: Phase 3
Study type: Interventional

The purpose of the study is to evaluate the effectiveness of two dosing regimens of fostamatinib compared to placebo, in patients with rheumatoid arthritis (RA) who are taking methotrexate and have had an inadequate response to a single TNF-alpha antagonist. The study will last for approximately six months.

NCT ID: NCT01197521 Completed - Clinical trials for Rheumatoid Arthritis

Evaluation of Effectiveness of Two Dosing Regimens of Fostamatinib Compared to Placebo in Patients With Rheumatoid Arthritis (RA) Who Are Taking Methotrexate But Not Responding.

OSKIRA - 1
Start date: September 2010
Phase: Phase 3
Study type: Interventional

The purpose of the study is to evaluate the effectiveness of two dosing regimens of fostamatinib compared to placebo, in patients with rheumatoid arthritis (RA) who are taking methotrexate but not responding. The study will last for 1 year.

NCT ID: NCT01196975 Completed - Influenza Clinical Trials

A Study to Evaluate the Safety and Immunogenicity of GSK Biologicals' Seasonal Influenza Vaccine in Adults

Start date: October 1, 2010
Phase: Phase 3
Study type: Interventional

This study is designed to test the immunogenicity and safety of an investigational influenza vaccine, in adults compared to two other influenza vaccines. This study will also evaluate the lot-to-lot consistency of three vaccine lots.

NCT ID: NCT01195727 Terminated - Clinical trials for Venous Thromboembolism

Multiple-Dose Study Apixaban in Pediatric Subjects With an Indwelling Central Venous Catheter

Start date: July 26, 2011
Phase: Phase 1
Study type: Interventional

CV185-079 is a multiple dose Apixaban Pharmacokinetics/Pharmacodynamics (PK/PD) study in pediatric subjects. The objective of this study is primarily to study the PK/PD of Apixaban in pediatric subjects with a central venous catheter.

NCT ID: NCT01195662 Completed - Type 2 Diabetes Clinical Trials

A Study of BMS-512148 (Dapagliflozin) in Patients With Type 2 Diabetes With Inadequately Controlled Hypertension on an ACEI or ARB and an Additional Antihypertensive Medication

Start date: October 2010
Phase: Phase 3
Study type: Interventional

The purpose of this study is to learn if BMS-512148 (Dapagliflozin), after 12 weeks, can improve (decrease) blood pressure in patients with type 2 diabetes with uncontrolled hypertension who are on an Angiotensin-converting enzyme inhibitor (ACEI) or an Angiotensin Receptor Blocker (ARB).The safety of this treatment will also be studied

NCT ID: NCT01194570 Completed - Clinical trials for Multiple Sclerosis, Primary Progressive

A Study of Ocrelizumab in Participants With Primary Progressive Multiple Sclerosis

Start date: March 2, 2011
Phase: Phase 3
Study type: Interventional

This randomized, parallel group, double-blind, placebo controlled study will evaluate the efficacy and safety of ocrelizumab in participants with primary progressive multiple sclerosis. Eligible participants will be randomized 2 : 1 to receive either ocrelizumab or placebo.