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NCT ID: NCT03992417 Active, not recruiting - Dermatitis Atopic Clinical Trials

Observational Study of Patients Receiving Dupixent® for Atopic Dermatitis (AD)

GLOBOSTAD
Start date: June 11, 2019
Phase:
Study type: Observational [Patient Registry]

Primary Objective: To characterize the patients who receive Dupixent® (dupilumab) for AD in a real-world setting, with respect to their medical history, socio-demographic and disease characteristics, and prior and concomitant treatments of AD Secondary Objectives: - To characterize real-world use patterns of Dupixent® for AD (eg, used regimens, reason for initiation of new treatments, concomitant therapies, treatment durations and reasons for discontinuation and/or switching) - To assess the long-term effectiveness of Dupixent® in AD patients in a real-world setting - To assess comorbid atopic conditions and effects of treatment in comorbid atopic conditions in patients who receive Dupixent® for AD - To collect safety data on study participants

NCT ID: NCT03990727 Recruiting - Clinical trials for Retinitis Pigmentosa

Phenotype Correlates Genotype of Inherited Retina Dystrophies, Retinitis Pigmentosa, Con>Rod Dystrophies.

Start date: August 2009
Phase:
Study type: Observational [Patient Registry]

Patients with retina dystrophies (retinitis pigmentosa, cone>rods dystrophies, Usher and syndromic) will be correlated with genotype and validate inheritance mode by segregation analysis.

NCT ID: NCT03990363 Completed - Clinical trials for Chronic Kidney Disease

A Study of Verinurad and Allopurinol in Patients With Chronic Kidney Disease and Hyperuricaemia

SAPPHIRE
Start date: July 23, 2019
Phase: Phase 2
Study type: Interventional

The purpose of this clinical research study is to establish the dose of verinurad combined with allopurinol 300 mg once daily that will elicit the desired response; ie, reduction in urinary albumin to creatinine ratio (UACR) at 6 months.

NCT ID: NCT03987919 Completed - Type 2 Diabetes Clinical Trials

A Study of Tirzepatide (LY3298176) Versus Semaglutide Once Weekly as Add-on Therapy to Metformin in Participants With Type 2 Diabetes

SURPASS-2
Start date: July 30, 2019
Phase: Phase 3
Study type: Interventional

The reason for this study is to compare the effect of the study drug tirzepatide to semaglutide on blood sugar levels in participants with type 2 diabetes. The study will last approximately 47 weeks and may include about 12 visits.

NCT ID: NCT03986138 Completed - Clinical trials for Lesion in Body Region

Efficacy and Safety of Gadopiclenol for Body Magnetic Resonance Imaging (MRI)

PROMISE
Start date: August 27, 2019
Phase: Phase 3
Study type: Interventional

The trial aims at evaluating the efficacy and the safety of gadopiclenol for body Magnetic resonance Imaging (MRI)

NCT ID: NCT03983655 Terminated - Clinical trials for Mild Cognitive Impairment

Effect of High Frequency/Low Intensity Transcranial Magnetic Stimulation in Cognitive Traits of an Elderly Population of Subjects With Mild Cognitive Impairment and Mild Dementia.

Start date: May 17, 2019
Phase: N/A
Study type: Interventional

There are no pharmacological interventions that delay or prevent the transition of mild cognitive impairment to dementia. Several studies have shown that transcranial magnetic stimulation (TMS) could be useful in increasing cognitive traits in dementia. As TMS is performed in a clinical setting, transportation, mobility and high costs of treatment, limit the number of TMS sessions dementia patients can receive. Most of the trials do not apply more than 20 TMS sessions Here, a randomized, sham controlled, paralallel group, clinical trial will be performed in order to asess the efficacy at improving cognitive traits of a novel TMS device that uses high frequency and low intensity pulses. As the device is portable and can be used from home without clinical supervision, the stimulation will be applied two times per day for a period of 6 months.

NCT ID: NCT03982394 Active, not recruiting - Clinical trials for Chronic Plaque Psoriasis

Observational Study of Patients With Moderate to Severe Chronic Plaque Psoriasis

VALUE
Start date: July 1, 2019
Phase:
Study type: Observational

This study will assess the use of risankizumab in adult patients with moderate to severe chronic plaque psoriasis and compare risankizumab to other commonly used biologics.

NCT ID: NCT03980314 Completed - Melanoma Clinical Trials

A Study to Compare Nivolumab Drug Product Process D to Nivolumab Drug Product Process C in Participants With Stage IIIa/b/c/d or Stage IV Melanoma After Complete Resection

Start date: June 24, 2019
Phase: Phase 1
Study type: Interventional

The purpose of this study is to compare the drug levels, immunogenicity and safety of Nivolumab Process D to Nivolumab Process C after complete resection of stage IIIa/b/c/d or stage IV melanoma.

NCT ID: NCT03979313 Completed - Clinical trials for Respiratory Syncytial Virus Infections

A Study to Evaluate the Safety and Efficacy of MEDI8897 for the Prevention of Medically Attended Lower Respiratory Tract Infection Due to Respiratory Syncytial Virus in Healthy Late Preterm and Term Infants (MELODY)

MELODY
Start date: July 23, 2019
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the efficacy, safety, pharmacokinetics (PK), and antidrug antibody (ADA) response for MEDI8897 in healthy late preterm and term infants who are 35 weeks or greater gestational age and entering their first RSV season.

NCT ID: NCT03979274 Completed - Healthy Clinical Trials

A Comparative Study of New Formulation and Approved Formulation for Levothyroxine in Healthy Volunteers

Start date: December 6, 2019
Phase: Phase 1
Study type: Interventional

The study investigated the bioequivalence between the new and the approved formulation for levothyroxine.