Retinitis Pigmentosa Clinical Trials

Browse current & upcoming clinical research / studies on Retinitis Pigmentosa. There are a total of 56 clinical trials for Retinitis Pigmentosa in 14 countries with 5 trials currently in the United States. 15 are either active and/or recruiting patients or have not yet been completed. Click the title of each study to get the complete details on eligibility, location & other facts about the study.

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Interventional trials
Determine whether experimental treatments or new ways of using known therapies are safe and effective under controlled environments.
Observational trials
Address health issues in large groups of people or populations in natural settings.
Participants are currently being recruited and enrolled.
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Study is ongoing (i.e., patients are being treated or examined), but enrollment has completed.
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Participants are not yet being recruited or enrolled.
Enrolling by invitation
Participants are being (or will be) selected from a predetermined population.
The study has concluded normally; participants are no longer being examined or treated (i.e., last patient's last visit has occurred).
Study halted prematurely, prior to enrollment of first participant.
Recruiting or enrolling participants has halted prematurely but potentially will resume.
Recruiting or enrolling participants has halted prematurely and will not resume; participants are no longer being examined or treated.
September 2015 - September 2017
hRPC is a cell therapy for retinitis pigmentosa. This is a first-in-human, dose escalation study in which participants with retinitis pigmentosa will receive a single subretinal injection of hRPC cells in one eye to evaluate safety and tolerability. Participants will be followed for one year to evaluate the safety and tolerability of hRPC Additional testing will seek to establish any preliminary efficacy from hRPC.
Sponsor: ReNeuron Limited
Study type: Interventional
July 2015 -
The aim of this study is to determine whether 9-cis-beta Caroten rich D. Brdawiil extract is effective in the treatment of retinitis pigmentosa in adolescent patients.
Sponsor: Sheba Medical Center
Study type: Interventional
May 2015 - June 2025
The purpose of this study is to investigate the role of continuous oxygen therapy combined with blue light deprivation in prevention and control of retinitis pigmentosa, in order to find a new strategy of treatment for retinitis pigmentosa.
Sponsor: Sun Yat-sen University
Study type: Interventional
January 2015 - January 2018
Retinitis Pigmentosa (RP) is the most common form of hereditary retinal degeneration, with a worldwide prevalence of 1:3500. It is one of the most genetically heterogenous conditions in humans, with over 100 causative genes and loci reported to date. However, in approximately 40% of patients the underlying genetic causes are yet to be found. The current study aims to identify causative RP genes and mutations in Israeli families of various ethnic backgrounds. Identification of such genes will contribute significantly to disease prevention (by identification of high risk families and appropriate genetic counseling) and to the investigators understanding of retinal structure and function and of the etiology of RP.
Sponsor: Hillel Yaffe Medical Center
Study type: Observational
November 2014 - October 2016
Objectives: To study the immediate effect and the persistent effect of Lycium barbarum (LB) treatment on retinal functions, especially the cone function, and retinal structure in patients with retinitis pigmentosa (RP) Design: Randomised controlled double-masked trial Setting: Primary Care clinical trial Participants: 120 RP subjects will be recruited from Ophthalmology department at The University of Hong Kong and the Retina Hong Kong. Interventions: Subjects will be randomly allocated to LB (treated with LB granules) or control (treated with placebo) groups for 1 year. After the 1st year, both groups will stop the treatment and all subjects will also have the same eye exam in 6-month period for the 2nd year. Main outcome measures: The primary outcome is the total sensitivity scores of 30-2 & 60-4 programmes of HVFA. The secondary outcomes are the b-wave amplitudes of ffERG responses, the amplitudes of direct component and induced component of mfERG, and the ETDRS visual acuity. Results: Lycium barbarum treatment provides the immediate effect and the persistent effect on retinal functions and structure in patients with retinitis pigmentosa to improve the cone activity. It does not cause any harmful effect to the subjects. Conclusion: Cone rescue is an alternative approach to save the vision for RP patients. The result of this study will provide valuable information for the treatment of RP. The antioxidative effect of LB is believed to delay or minimize the cone degeneration in RP and the intake of LB will be a very economic way in the RP treatment.
Sponsor: The Hong Kong Polytechnic University
Study type: Interventional
November 2014 - August 2016
The purpose of this study is to evaluate the safety of intravitreal injection of autologous bone marrow stem cells in patients with retinitis pigmentosa by a prospective, single-center, randomized, parallel, double-blind, phase I placebo-controlled clinical trial.
Sponsor: Red de Terapia Celular
Study type: Interventional
November 2014 - November 2018
This is a post-market study of the Argus II Retinal Prosthesis System. The study is being conducted in France. The objective of the study is to obtain data to further demonstrate the effectiveness and evaluate the safety of Argus II System in patients with retinitis pigmentosa who have a bare light perception or worse in both eyes.
Sponsor: Second Sight Medical Products
Study type: Observational
September 2014 - November 2016
Retinitis pigmentosa is an eye disease in which there is damage to the retina. The retina is the layer of tissue at the back of the inner eye that converts light images to nerve signals and sends them to the brain.Autologous Bone Marrow derived Mono Nuclear Stem Cell (BMMNCs) is used for this condition .
Sponsor: Chaitanya Hospital, Pune
Study type: Interventional
August 2014 - June 2015
Retinitis pigmentosa (RP) is a slowly progressive retinal degeneration for which there is no proven treatment. Patients are interested in trying alternative therapies to try to reduce their vision loss, but only limited research evidence exists to support their use and potential benefit. The goal of this research project is to gain a better understanding of possible changes in ocular and retinal blood flow and measures of vision in RP patients receiving two promising therapies, electroacupuncture and transcorneal electrical stimulation.
Sponsor: Nova Southeastern University
Study type: Interventional
May 2014 - May 2016
Background: - Some people with retinitis pigmentosa (RP) have macular edema (swelling) in the central retina. This can cause decreased central vision. The cause of macular edema is unknown, but may involve inflammation. The drug minocycline might help prevent inflammation and therefore might help treat macular edema and improve central visual function . Objectives: - To see if minocycline helps people with RP.and macular edema. Eligibility: - People 12 years and older with RP who have macular edema in at least on eye. Design: - Participants will be screened with medical and eye disease history. They will have an eye exam and blood tests. One eye with macular edema will be the study eye. If both eyes are affected, one will be designated the study eye. - Participants will visit the clinic at least 9 times over at least 14 months. The first 3 study visits will be monthly, then every 2 months. - Participants will start taking minocycline after visit 3. They will take 1 pill twice daily for at least 1 year. - Participants will keep a medicine diary and bring it to each visit with their pill bottle and unused pills. - At each study visit, participants will have some or all of the following tests: - eye and thyroid exams - blood and pregnancy tests - microperimetry: participants will press a button when they see a light on a computer screen - visual field measurement: participants will look at spots on a white screen to test side vision - electroretinogram: A person will be dark adapted by sitting in the dark for 30 minutes. After the placement of numbing eye drops, special contact lenses will be placed . The participant will watch flashing lights and recordings will be made.
Sponsor: National Institutes of Health Clinical Center (CC)
Study type: Interventional
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