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Retinitis Pigmentosa clinical trials

View clinical trials related to Retinitis Pigmentosa.

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NCT ID: NCT02759952 Recruiting - Clinical trials for Retinitis Pigmentosa

Clinical Characterization on PDE6A-related Retinitis Pigmentosa in Preparation to a Gene Therapy Trial

Start date: February 2013
Phase: N/A
Study type: Observational

Mutations in the PDE6A gene - encoding the -subunit of the rod cGMP-phosphodiesterase - account for 1% of autosomal recessive retinitis pigmentosa (arRP) through impaired regulation of cGMP levels in the rod outer segment. This study aims for a detailed clinical characterization of patients with PDE6A mutations in preparation of a clinical gene replacement study (phase I/II safety trial).

NCT ID: NCT02720640 Recruiting - Clinical trials for Retinitis Pigmentosa

Safety and Efficacy of the Alpha AMS Subretinal Implant

OX-RI
Start date: May 2015
Phase: N/A
Study type: Interventional

The aim of this single-centre study is to assess the safety and efficacy of the Retina Implant Alpha AMS (Retina Implant AG, Reutlingen, Germany) in participants with severe visual impairment secondary to outer retinal degeneration caused by retinitis pigmentosa (RP). The study is sponsored by the University of Oxford and funded by the National Institute for Health Research (UK).

NCT ID: NCT02709876 Recruiting - Clinical trials for Retinitis Pigmentosa

Autologous Bone Marrow-Derived CD34+, CD133+, and CD271+ Stem Cell Transplantation for Retinitis Pigmentosa

Start date: April 2014
Phase: Phase 1/Phase 2
Study type: Interventional

A single arm, single center trial to evaluate the safety and efficacy of autologous purified populations of bone-marrow derived stem cells in patients with Retinitis Pigmentosa (BM-SCs) through a 48 month follow up period.

NCT ID: NCT02670980 Recruiting - Clinical trials for Retinitis Pigmentosa

Compensation for Blindness With the Intelligent Retinal Implant System (IRIS V2) in Patients With Retinal Dystrophy

IRIS 2
Start date: January 2016
Phase: N/A
Study type: Interventional

This study evaluates the safety and effectiveness of the Intelligent Retinal Implants System (IRIS V2). Blind patient suffering from Retinitis Pigmentosa, Cone Rod Dystrophy, or Choroideremia are implanted with an Intelligent Retinal Implant Systeme. All subjects undergo ophthalmological examinations in predefined intervals after implantation. Ophthalmological examinations include funduscopy, slit lamp examination and OCT. All adverse events are recorded and analyzed. Efficacy is measured using functional vision and visual function tests before and after implantation as well as with the system on and system off.

NCT ID: NCT02661711 Recruiting - Clinical trials for Retinitis Pigmentosa

Aflibercept for Macular Oedema With Underlying Retinitis Pigmentosa (AMOUR) Study

AMOUR
Start date: March 2016
Phase: Phase 2
Study type: Interventional

The purpose of this study is to assess the safety and efficacy of intravitreal injections of Aflibercept (Eylea) in treating Cystoid Macula Oedema (CMO) in patients with underlying Retinitis Pigmentosa (RP).

NCT ID: NCT02617966 Recruiting - Clinical trials for Retinitis Pigmentosa

Rod and Cone Mediated Function in Retinal Disease

Start date: November 2015
Phase: N/A
Study type: Observational

Background: Retinal diseases cause the loss of rod and cone photoreceptors. Symptoms include vision loss and night blindness. Researchers want to learn about rod and cone function in healthy people and people with retinal disease. They want to know if how well a person sees in the dark can test the severity of retinal disease. Objectives: To find out if how well a person sees in the dark can test the severity of retinal disease. To find out if this can help detect retinal disease and track its changes. Eligibility: People ages 5 and older with: Retinal disease OR 20/20 vision or better with or without correction in at least one eye Design: Participants will be screened with medical and eye history and eye exam. Those with retinal disease will also have: Eye imaging: Drops dilate the eye and pictures are taken of it. Visual field testing: Participants look into a bowl and press a button when they see light. Electroretinogram (ERG): An electrode is taped to the forehead. Participants sit in the dark with their eyes patched for 30 minutes. Then they get numbing drops and contact lenses. Participants watch lights while retina signals are recorded. Visit 1 will be 3 8 hours. Participants will have up to 6 more visits over 6 12 months. Visits include: Eye exam and imaging Time course of dark adaptation: Participants view a background light for 5 minutes then push a button when they see colored light. Dark adapted sensitivity: Participants sit in the dark for 45 minutes. They push a button when they see colored light. For participants with retinal disease, ERG and visual field testing

NCT ID: NCT02614651 Not yet recruiting - Glaucoma Clinical Trials

AUgmented REality for the Visually Impaired - Part 1

AUREVI 1
Start date: October 2016
Phase: N/A
Study type: Interventional

The main objective of this study is to quantify vision parameters in subjects with concentric visual field constriction, and this in relation to the display on virtual reality goggles. More specifically: - The maximum brightness value for visual comfort (THRESHOLD_MAX) - The minimum value of the perceptible light contrast in low light perceptible (THRESHOLD_MIN) - The speed of light change adaptation in the range [THRESHOLD_MAX-THRESHOLD_MIN] and [THRESHOLD_MIN-THRESHOLD_MAX].

NCT ID: NCT02609165 Active, not recruiting - Clinical trials for Retinitis Pigmentosa

Nerve Growth Factor Eye Drops Treatment in Patients With Retinitis Pigmentosa and Cystoid Macular Edema

NEMO
Start date: May 2015
Phase: Phase 2
Study type: Interventional

This study aims at investigating the therapeutic potential of recombinant human Nerve Growth Factor ( rhNGF ) eye drops treatment in patients with Retinitis Pigmentosa (RP) associated with cystoid macular edema (CME) in a phase II, randomized, double-masked, controlled clinical trial.

NCT ID: NCT02588430 Not yet recruiting - Clinical trials for Retinitis Pigmentosa

Post-Marketing Surveillance of Patients Using the Subretinal Retina Implant Alpha

Start date: January 2016
Phase: N/A
Study type: Observational [Patient Registry]

This study is a non-invasive registry to monitor the safety and efficacy of patients using the CE-certified RETINA IMPLANT Alpha.

NCT ID: NCT02575430 Completed - Clinical trials for Retinitis Pigmentosa (RP)

Natural History Study in Inherited Retinal Disease Subjects Caused by Mutations in RPE65 or LRAT

Start date: December 2015
Phase: N/A
Study type: Observational

To evaluate the natural history of visual function in subjects with IRD phenotypically diagnosed as Leber congenital amaurosis (LCA) or retinitis pigmentosa (RP) caused by RPE65 or LRAT gene mutations.