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NCT ID: NCT00143143 Completed - Epilepsies, Partial Clinical Trials

Pregabalin Open-Label Extension Trial in Patients With Partial Seizures

Start date: September 2001
Phase: Phase 3
Study type: Interventional

The primary purpose of the protocol is to evaluate the long-term safety of pregabalin in patients with partial seizures.

NCT ID: NCT00141323 Completed - Osteoporosis Clinical Trials

Postmenopausal Evaluation and Risk-reduction With Lasofoxifene (PEARL)

PEARL
Start date: November 2001
Phase: Phase 3
Study type: Interventional

The purpose of the study is to determine the safety and effectiveness of 2 doses of the investigational drug, lasofoxifene, compared to placebo (an inactive substance) in reducing new spinal fractures in women with osteoporosis.

NCT ID: NCT00141102 Completed - Osteoarthritis Clinical Trials

Study Of Celecoxib Or Diclofenac And Omeprazole For Gastrointestinal (GI) Safety In High GI Risk Patients With Arthritis

CONDOR
Start date: October 2005
Phase: Phase 4
Study type: Interventional

To determine whether celecoxib is superior to combined therapy with diclofenac and omeprazole in the incidence of clinically significant upper and/or lower gastrointestinal (GI) events in high GI risk subjects with osteoarthritis and/or rheumatoid arthritis.

NCT ID: NCT00133952 Completed - Clinical trials for Diabetic Macular Edema

Effect of Ruboxistaurin on Clinically Significant Macular Edema

Start date: August 2005
Phase: Phase 3
Study type: Interventional

The purpose of the study is to test the hypothesis that oral administration of ruboxistaurin will reduce the occurrence of sustained moderate visual loss (SMVL) in patients with clinically significant macular edema. SMVL is defined as a 15 letter or more decrease from baseline in best-corrected Early Treatment Diabetic Retinopathy Study (ETDRS) visual acuity that is sustained for the patient's last 6 months of study participation. The SMVL data from this study will be combined with the SMVL data from Study B7A-MC-MBDL for the purpose of comparing ruboxistaurin to placebo.

NCT ID: NCT00111670 Completed - Clinical trials for Diabetes Mellitus Type 2

A Study of DPP-IV Inhibitor in Patients With Type 2 Diabetes

Start date: June 2005
Phase: Phase 2
Study type: Interventional

This study will assess the efficacy, safety and tolerability of DPP-IV Inhibitor compared to placebo in patients with type 2 diabetes. The anticipated time on study treatment is < 3 months and the target sample size is 100-500 individuals.

NCT ID: NCT00111644 Completed - Clinical trials for Pneumonia, Bacterial

A Study to Assess Beta-Lactam in the Treatment of Hospitalized Patients With Bacterial Pneumonia

Start date: March 2005
Phase: Phase 2
Study type: Interventional

This study will assess the efficacy and safety of intravenous beta-lactam, in comparison with ceftriaxone, in hospitalized patients with community-acquired pneumonia not caused by Legionella. The anticipated time on study treatment is 3-12 months and the target sample size is 100-500 individuals.

NCT ID: NCT00109408 Completed - Clinical trials for Rheumatoid Arthritis

A Study to Assess the Safety and Efficacy of Tocilizumab in Patients With Active Rheumatoid Arthritis

Start date: July 2005
Phase: Phase 3
Study type: Interventional

This 2 arm study will assess the safety and efficacy of tocilizumab monotherapy versus methotrexate in patients with active rheumatoid arthritis (RA). Patients will be randomized to receive tocilizumab 8mg/kg iv every 4 weeks plus placebo po weekly, or methotrexate 7.5-20mg po weekly plus placebo iv every 4 weeks. The anticipated time on study treatment is 3-12 months and the target sample size is 500+ individuals.

NCT ID: NCT00095290 Completed - Albuminuria Clinical Trials

Irbesartan Versus Placebo in Combination With Ramipril for Treatment of Albuminuria

Start date: September 2004
Phase: Phase 4
Study type: Interventional

Albumin in the urine is usually a signal that you might be at risk of cardiovascular complications. The purpose of this study is to determine if the albumin in your urine can be decreased by the treatment regimen that consists of irbesartan taken at the same time with ramipril.

NCT ID: NCT00094549 Completed - Bipolar Disorder Clinical Trials

Olanzapine vs. Comparator and Placebo in the Treatment of Patients With Bipolar I Disorder

Start date: October 2004
Phase: Phase 4
Study type: Interventional

The goals of this study are: A. To determine whether olanzapine can help patients with bipolar disorder who currently have mild to moderate mania. B. To assess the safety of olanzapine and any side effects that might be associated with it, as well as the quality of life and functioning of patients treated with olanzapine. C. To assess how olanzapine compares to divalproex.

NCT ID: NCT00091442 Completed - Breast Cancer Clinical Trials

A Study of Docetaxel Monotherapy or DOXIL and Docetaxel in Patients With Advanced Breast Cancer

Start date: September 2004
Phase: Phase 3
Study type: Interventional

The purpose of the study is to evaluate whether the time to progression for the DOXIL and docetaxel combination therapy group was superior to that of the group treated with docetaxel monotherapy in participants with advanced breast cancer.