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NCT ID: NCT02214121 Completed - Clinical trials for Investigation of Platelet Aggregation in Paediatric Patients With Sickle Cell Disease

A Pharmacokinetic (PK) and Pharmacodynamic (PD) Dose-ranging Phase II Study of Ticagrelor in Paediatric Patients With Sickle Cell Disease

HESTIA 1
Start date: September 11, 2014
Phase: Phase 2
Study type: Interventional

The purpose of this Phase II dose-ranging study is to investigate pharmacokinetic (PK) and pharmacodynamic (PD) properties of various doses of ticagrelor followed by 4 weeks of twice-daily treatment in paediatric patients with sickle cell disease

NCT ID: NCT02213263 Completed - Follicular Lymphoma Clinical Trials

A Study Of PF-05280586 (Rituximab-Pfizer) Or MabThera® (Rituximab-EU) For The First-Line Treatment Of Patients With CD20-Positive, Low Tumor Burden, Follicular Lymphoma (REFLECTIONS B328-06)

Start date: September 30, 2014
Phase: Phase 3
Study type: Interventional

This study will compare the safety and effectiveness of PF-05280586 versus rituximab-EU in patients with CD20-positive, low tumor burden follicular lymphoma. The primary hypothesis to be tested in this study is that the effectiveness of PF-05280586, as measured by the Overall Response Rate, is similar to that of rituximab-EU.

NCT ID: NCT02213159 Completed - Obesity Clinical Trials

Dexmedetomidine for Postoperative Analgesia After Bariatric Surgery

Start date: July 2014
Phase: Phase 2/Phase 3
Study type: Interventional

The purpose of this study is to determine if Dexmedetomidine given at the end of surgery will reduce postoperative morphine consumption and improve postoperative quality of recovery as compared to morphine in patients undergoing laparoscopic bariatric surgery.

NCT ID: NCT02210819 Completed - Clinical trials for Deep Vein Thrombosis (DVT)

Treatment of Venous Thromboembolism (VTE) With Either Rivaroxaban or Current Standard of Care Therapy

XALIA LEA
Start date: June 27, 2014
Phase:
Study type: Observational

Following the findings of the clinical trials in drug development, this global non-interventional cohort field study will investigate rivaroxaban under clinical practice conditions in comparison with current standard of care for patients with acute venous thoromboembolism (VTE). The main goal is to analyze long-term safety in the use of rivaroxaban in the treatment of acute VTE in routine clinical practice.

NCT ID: NCT02183857 Completed - Clinical trials for Time Needed to Achieve a Successful Cannulation of the Femoral Artery in Pediatric Cardiac Surgery

Ultrasound-Guided vs Landmark Technique for Femoral Arterial Cannulation in Pediatric Cardiac Surgery

Start date: July 2014
Phase: N/A
Study type: Interventional

The use of ultrasound guidance by senior residents learning the technique of femoral artery catheterization is superior to the landmark technique.

NCT ID: NCT02172950 Completed - Hemophilia A Clinical Trials

An Open-label Safety and Efficacy Study of Recombinant FVIII in Patients With Severe Hemophilia A

Start date: October 13, 2014
Phase: Phase 3
Study type: Interventional

This multicenter, open-label, phase 3 extension study will investigate the safety and efficacy of rVIII-SingleChain for prophylaxis and on-demand treatment of bleeding episodes in at least 200 previously treated patients (PTPs) with severe congenital hemophilia A and previous exposure to FVIII products who achieve at least 100 exposure days (EDs) to rVIII-SingleChain in this study, as well as in previously untreated patients (PUPs) with no previous exposure to any FVIII product who achieve at least 50 EDs to rVIII-SingleChain in this study. A substudy (open to both PTPs and PUPs) will investigate the use of rVIII-SingleChain in surgery. A substudy (open to PUPs who develop an inhibitor to rVIII-SingleChain) will investigate the use of rVIII-SingleChain in immune tolerance induction (ITI) therapy.

NCT ID: NCT02162732 Completed - Clinical trials for Renal Cell Carcinoma

Molecular-Guided Therapy for Childhood Cancer

Start date: July 8, 2014
Phase: N/A
Study type: Interventional

The purpose of this study is to test the feasibility (ability to be done) of experimental technologies to determine a tumor's molecular makeup. This technology includes a genomic report based on DNA exomes and RNA sequencing that will be used to discover new ways to understand cancers and potentially predict the best treatments for patients with cancer in the future.

NCT ID: NCT02159911 Completed - Adverse Effects Clinical Trials

Oral Misoprostol for Cervical Priming Before Hysteroscopy

Start date: June 2004
Phase: N/A
Study type: Observational

A randomized, double blind study to compare 200 and 400 mcg misoprostol for cervical preparation before hysteroscopy.

NCT ID: NCT02153411 Completed - Asthma Clinical Trials

Multicentric, Transversal, Descriptive, Epidemiological Study on the Management of Asthma in Asthmatic Middle East Adult Population

ESMAA
Start date: June 2014
Phase: N/A
Study type: Observational

Descriptive study on the management of asthma in asthmatic Middle East adult population : Algeria,Egypt, Irak,Iran, Jordan, Koweit, Lebanon, Qatar,Saudi,Tunisia, UAE

NCT ID: NCT02143531 Completed - Clinical trials for Postoperative Nausea and Vomiting

Intravenous Haloperidol Versus Ondansetron for Treatment of Established Post-operative Nausea and Vomiting

Start date: September 2008
Phase: Phase 4
Study type: Interventional

This study aims to prove that at a dose of 1 mg Haloperidol possesses a high success rate in controlling established postoperative nausea and vomiting (PONV) in the first 24 hours following administration similar to the standard of care ondansetron 4 mg.