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NCT ID: NCT02791347 Completed - Malnutrition Clinical Trials

Nutrition Intervention Among Stem Cell Recipients: Post Hospital Discharge

Start date: August 2016
Phase: N/A
Study type: Interventional

Chemotherapy conditioning, preceding Stem Cell Transplantation (SCT), has been associated with severe gastrointestinal toxicity, commonly compromising patients' food intake, nutritional status and functioning level. Malnutrition has been associated with worse functional status, reduced survival, increased rate of infections, complications, hospitalizations, and therapy toxicity in oncology patients. To date, there is no Randomized Controlled Trials (RCT) assessing the impact of a nutrition intervention on SCT patients who remain at risk of malnutrition even 100 days post SCT. The proposed study is a single center, prospective, RCT with a parallel design that aims to assess the impact of a nutrition intervention on the nutritional and functional statuses of SCT recipients 100 days post SCT.

NCT ID: NCT02786576 Completed - Clinical trials for Hidradenitis Suppurativa

Effectiveness of Adalimumab in Moderate to Severe HidrAdenitis SuppuRativa Patients - a Multi cOuNtry studY in Real Life Setting

HARMONY
Start date: July 5, 2016
Phase:
Study type: Observational

This study will assess the effects of adalimumab treatment in moderate to severe Hidradenitis Suppurativa (HS) patients in the real world setting. The objectives of this study are to estimate the effectiveness of adalimumab treatment on disease severity, to estimate the impact of adalimumab treatment on patients' quality of life, psychological effect, work productivity and healthcare resource utilization and to describe treatment practices over the study period.

NCT ID: NCT02737670 Completed - Clinical trials for Tinnitus, Subjective

Sulodexide Efficacy in Chronic Idiopathic Subjective Tinnitus

SECIST
Start date: August 2014
Phase: Phase 2
Study type: Interventional

The objective of this prospective randomized and double blind controlled study is to evaluate the efficacy and safety of Sulodexide (25 mg) in the treatment of chronic idiopathic subjective tinnitus.

NCT ID: NCT02737657 Completed - Clinical trials for Diabetes Mellitus, Type 2

An Observational Study to Evaluate Tolerability of Canagliflozin and Sulphonylurea in Type 2 Diabetes Patients During Ramadan

CRATOS
Start date: April 2016
Phase: Phase 4
Study type: Observational

The primary purpose of this study is to describe the tolerability of canagliflozin and any sulphonylurea (each administered with metformin with or without a DPP-4 inhibitor), in terms of the percentage of patients with at least one episode of hypoglycaemia, in patients with T2DM who fast during Ramadan.

NCT ID: NCT02730377 Completed - Clinical trials for Diabetes Mellitus, Type 2

Efficacy in Controlling Glycaemia With Victoza® (Liraglutide) as add-on to Metformin vs. OADs as add-on to Metformin After up to 104 Weeks of Treatment in Subjects With Type 2 Diabetes

LIRA-PRIME
Start date: March 28, 2016
Phase: Phase 4
Study type: Interventional

This trial is conducted globally. The aim of the trial is to investigate efficacy in controlling glycaemia with Victoza® (liraglutide) as add-on to metformin background treatment vs. OADs as add-on to metformin background treatment for 104 weeks of treatment in subjects with type 2 diabetes.

NCT ID: NCT02704091 Completed - Acute Diarrhoea Clinical Trials

Efficacy of Diosmectite (Smecta®) in the Symptomatic Treatment of Acute Diarrhoea in Adults

ADIASE
Start date: March 17, 2016
Phase: Phase 4
Study type: Interventional

The purpose of the study is to demonstrate that diosmectite efficacy is superior to placebo regarding time to recovery of an acute diarrhoea episode presumed of infectious origin in adult subjects.

NCT ID: NCT02678312 Completed - Clinical trials for Pediatric Heart Failure

Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of LCZ696 Followed by a 52-week, Double-blind Study of LCZ696 Compared With Enalapril in Pediatric Patients With Heart Failure

Start date: November 3, 2016
Phase: Phase 2/Phase 3
Study type: Interventional

This study consists of two parts (Part 1 and Part 2). The purpose of Part 1 is to evaluate the way the body absorbs, distributes, metabolizes and removes the drug LCZ696. This will help determine the proper dose of LCZ696 for Part 2 of the study. The purpose for Part 2 is to compare the effectiveness and safety of LCZ696 with enalapril in a double-blind manner, in pediatric heart failure patients over 52 weeks of treatment.

NCT ID: NCT02676921 Completed - Clinical trials for Sinus; Empyema, Maxillary (Chronic)

The Osteogenic Potential of Human Maxillary Sinus Shneiderian Membrane

HMSSM
Start date: March 2014
Phase: N/A
Study type: Observational [Patient Registry]

The objectives of this study are : 1. to test the the osteogenic potential of human maxillary sinus schneiderian membrane (hMSSM). 2. To investigate the expression of mesenchymal stem cell marker (STRO-1), a marker of mesenchymal progenitor cells using flow cytometry, and Alkaline phosphate expression, Red alizarin and Von Kossa staining and quantitive PCR.

NCT ID: NCT02661217 Completed - Clinical trials for Heart Failure With Reduced Ejection Fraction

Comparison of Pre- and Post-discharge Initiation of LCZ696 Therapy in HFrEF Patients After an Acute Decompensation Event

TRANSITION
Start date: February 12, 2016
Phase: Phase 4
Study type: Interventional

To explore two modalities of treatment initiation (Pre-discharge, and Post-discharge) with LCZ696 in HFrEF patients following stabilization after an ADHF episode.

NCT ID: NCT02658058 Completed - Anesthesia Clinical Trials

Pre-procedural Ultrasound Techniques Versus Conventional Landmark Technique of Spinal Anesthesia in Elderly Patients

Start date: November 2015
Phase: N/A
Study type: Interventional

Traditionally, spinal anesthesia is performed using the palpation of bony landmark to identify the level and point of entry of the spinal needle. Recently, ultrasound imaging has become an increasingly popular procedure among anesthesiologists to guide neuraxial blockade. Most of the studies on pre-procedural ultrasound-guided neuraxial techniques are limited to a midline approach using a transverse median views. The parasagittal oblique view consistently offers better ultrasound view of the neuraxis compared to the transverse median view. However, it is still not evident whether these superior parasagittal oblique views will lead to an easier paramedian needle insertion. In the literature, there are no studies directly comparing the US-guided paramedian approach using the parasagittal oblique (PSO) view, the US-guided midline approach using the transverse median view, and the conventional landmark midline approach to perform spinal anesthesia in the elderly patients, in particular for the teaching of novice anesthesia residents.