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Hidradenitis Suppurativa clinical trials

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NCT ID: NCT03248531 Not yet recruiting - Clinical trials for Hidradenitis Suppurativa

A Study to Test the Efficacy, Safety and Pharmacokinetics of Bimekizumab in Subjects With Moderate to Severe Hidradenitis Suppurativa.

Start date: September 1, 2017
Phase: Phase 2
Study type: Interventional

Hidradenitis suppurativa (HS) is a painful, long-term skin condition that causes abscesses and scarring on the skin.

NCT ID: NCT03238469 Not yet recruiting - Clinical trials for Hidradenitis Suppurativa

Microwave Ablation in Mild Axillary Hidradenitis Suppurativa

WAVE
Start date: September 1, 2017
Phase: N/A
Study type: Interventional

With microwave ablation (MWA), using the heat generated from electromagnetic waves in the microwave energy spectrum, hair follicles and apocrine glands in the (hypo)dermis are ablated through thermolysis. MWA was recently approved for the treatment of axillary hyperhidrosis (miraDry) and removal of axillary hair (miraSmooth). By permanent removal of hairs and sweat glands, the investigators hypothesize a beneficial and long-term sustainable preventive effect of MWA in HS patients.

NCT ID: NCT03221621 Not yet recruiting - Clinical trials for Hidradenitis Suppurativa

Cost-effectiveness of Adalimumab and Surgery vs Adalimumab in HS

HS-COST
Start date: August 1, 2017
Phase: Phase 4
Study type: Interventional

The primary objective of this randomized controlled clinical trial in a real life setting is to evaluate the cost-utility of limumab monotherapy compared with the combination of adalimumab and a maximum of three surgeries after two years of treatment in adult patients with moderate to severe HS.

NCT ID: NCT03203122 Recruiting - Clinical trials for Hidradenitis Suppurativa

Intense Pulsed Light Therapy for Hidrosadenitis Suppurativa

Start date: August 7, 2017
Phase: N/A
Study type: Interventional

6 monthly treatments with IPL laser in patients with Hidradenitis Suppurativa. The effect in measured on several severity scores.

NCT ID: NCT03173144 Not yet recruiting - Psoriasis Clinical Trials

Chronic Inflammatory Disease, Lifestyle and Treatment Response

BELIEVE
Start date: June 1, 2017
Phase: N/A
Study type: Observational [Patient Registry]

Chronic inflammatory diseases (CID) - including inflammatory bowel diseases (Crohn's disease and ulcerative colitis), rheumatic conditions (rheumatoid arthritis, axial spondyloarthritis, psoriatic arthritis), inflammatory skin diseases (psoriasis, hidradenitis suppurativa) and non-infectious uveitis are treated with biologics targeting the pro-inflammatory molecule tumour necrosis factor-α (TNF), i.e. TNF inhibitors. Up to one third of the patients do, however, not respond to biologics and lifestyle is assumed to affect the treatment outcome. However, little is known on the effects of lifestyle as a prognostic factor (possibly enabling personalised medicine). The aims of this multidisciplinary collaboration are to identify lifestyle factors that support individualised forecasting of optimised treatment outcome on these costly drugs. This prospective cohort study will enrol CID patients assigned for TNF-α inhibitors. At baseline (Pre-treatment), patient characteristics are assessed using patient-reported outcome measures and clinical assessments on disease activity, quality of life, and lifestyle together with registry data on comorbidity and medication. Follow-up will be conducted at week 14-16 after treatment initiation (according to the current Danish standards). Evaluation of a successful treatment outcome response will - for each disease - be based on most frequently used primary endpoints; the major outcome of the analyses will be to detect differences in treatment outcome between patients with specific lifestyle characteristics. The overarching goal of this project is to improve the lives of patients suffering from CID, by providing evidence to support dietary recommendations likely to improve the clinical outcome. The study is approved by the local Ethics Committee (S-20160124) and the local Data Agency (2008-58-035). The study findings will be disseminated in peer-reviewed journals, via patient associations, and presented at national and international conferences.

NCT ID: NCT03146676 Recruiting - Clinical trials for Hidradenitis Suppurativa

The Ohio State University Dermatology Biorepository, Molecular Biology and Genetics of Hidradenitis Suppurativa

Start date: April 19, 2017
Phase: N/A
Study type: Observational

Analysis of Gene expression and microbiome profiling in hidradenitis suppurativa to identify immunological biomarkers of disease activity.

NCT ID: NCT03103074 Recruiting - Clinical trials for Hidradenitis Suppurativa

Pilot Study on Botulinum Toxin B as Treatment for Hidradenitis Suppurativa

Start date: May 24, 2017
Phase: N/A
Study type: Interventional

Randomized double blind placebo controlled pilot study/proof of concept-study to see if intradermal injection with Botulinum toxin B is an effective treatment of Hidradenitis suppurativa

NCT ID: NCT03099980 Recruiting - Clinical trials for Hidradenitis Suppurativa

Exploratory Trial Evaluating Cosentyx (Secukinumab) for Patients With Moderate-to-Severe Hidradenitis Suppurativa

Start date: July 11, 2016
Phase: Early Phase 1
Study type: Interventional

This is a pilot study in which the the safety and feasibility of secukinumab in HS patients as well as information about the effect size will be determined in order to inform a future larger randomized control trial with an active comparator.

NCT ID: NCT03054155 Recruiting - Clinical trials for Hidradenitis Suppurativa

Treatment of Hidradenitis Suppurativa With Eth 755nm Alexandrite Laser

Start date: May 11, 2017
Phase: N/A
Study type: Interventional

Patients with bilateral hidradenitis in the axilla, groin and/or inframammary will be treated on one side with the Alexandrite hair removal laser. The other side will serve as the control.

NCT ID: NCT03049267 Recruiting - Clinical trials for Hidradenitis Suppurativa

Short-term Safety, Efficacy and Mode of Action of Apremilast in Moderate Suppurative Hidradenitis

SMASH
Start date: February 2, 2017
Phase: Phase 2
Study type: Interventional

Study design: A double-blind randomised placebo-controlled trial Intervention: Randomized placebo controlled treatment of 20 HS patients of which fifteen patients will be randomized to apremilast and five patients to placebo. The total duration of the treatment period per subject is 16 weeks. Primary objectives: To evaluate the expression profile of inflammatory cytokines in HS lesional skin at week four (t=4) and week sixteen (t=16): - of patients receiving apremilast compared to placebo; - within both groups relative to baseline (t=0). Secondary objectives: - To prospectively evaluate the clinical efficacy of apremilast. - To assess the effect of apremilast on patient reported outcomes measures. - To assess the short-term safety and tolerability of apremilast in patients with hidradenitis suppurativa.