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NCT ID: NCT04552470 Completed - Clinical trials for Type 2 Diabetes Mellitus

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of PF-06882961 in Japanese Adults With Type 2 Diabetes Mellitus

Start date: October 26, 2020
Phase: Phase 1
Study type: Interventional

This is a Phase 1, randomized, double blind (sponsor open), parallel, placebo controlled, twice daily oral dosing study of PF 06882961 in adult Japanese participants with T2DM inadequately controlled on diet and exercise alone.

NCT ID: NCT04551950 Completed - Cervical Cancer Clinical Trials

Bintrafusp Alfa Combination Therapy in Participants With Cervical Cancer (INTR@PID 046)

Start date: October 19, 2020
Phase: Phase 1
Study type: Interventional

This study was to evaluate the safety and tolerability of bintrafusp alfa in combination with other anti-cancer therapies in participants with locally advanced or advanced cervical cancer.

NCT ID: NCT04546581 Completed - COVID-19 Clinical Trials

Inpatient Treatment of COVID-19 With Anti-Coronavirus Immunoglobulin (ITAC)

Start date: October 8, 2020
Phase: Phase 3
Study type: Interventional

This protocol will serve as a platform for assessing treatments for adult patients hospitalized for medical management of COVID-19 without related serious end-organ failure. Trials will involve sites around the world strategically chosen to ensure rapid enrollment. This trial will compare hyperimmune intravenous immunoglobulin (hIVIG) with matched placebo, when added to standard of care (SOC), for preventing further disease progression and mortality related to COVID-19. SOC will include remdesivir unless it is contraindicated for an individual patient.

NCT ID: NCT04542525 Completed - Aphakia Clinical Trials

Clinical Investigation of an AcrySof IQ PanOptix Toric Intraocular Lens

Start date: December 1, 2020
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the effectiveness and safety of the TFNT20 low cylinder power intraocular lens when implanted in the eye to replace the natural lens following cataract removal.

NCT ID: NCT04542252 Completed - Clinical trials for Drug Drug Interaction

Drug-Drug Interaction Study of Intravenous Administration of SyB V-1901 and Cyclosporine in Japanese Healthy Subjects

Start date: November 9, 2020
Phase: Phase 1
Study type: Interventional

To evaluate the effect of coadministered cyclosporine on the pharmacokinetics of brincidofovir following simultaneous administration of SyB V-1901 with cyclosporine, or coadministration of cyclosporine at 2 hours after the completion of SyB V-1901 infusion in healthy adult subjects

NCT ID: NCT04542070 Completed - HIV Infections Clinical Trials

A Study to Evaluate Efficacy and Safety of Cabotegravir (CAB) Long Acting (LA) Plus (+) Rilpivirine (RPV) LA Versus BIKTARVY® (BIK) in Participants With Human Immunodeficiency Virus (HIV)-1 Who Are Virologically Suppressed

SOLAR
Start date: November 9, 2020
Phase: Phase 3
Study type: Interventional

This study is designed to assess the antiviral activity and safety of a two-drug regimen of CAB LA + RPV LA compared with maintenance of BIK. BIKTARVY is a registered trademark of Gilead Sciences.

NCT ID: NCT04534114 Completed - Clinical trials for End Stage Renal Disease Requiring Hemodialysis

Factor XI LICA to Reduce Events Such as Heart Attack and Stroke in Patients Whose Kidneys Are no Longer Able to Work as They Should and Require Treatment to Filter Wastes From the Blood: Focus is on the Safety of BAY2976217 and the Way the Body Absorbs, Distributes and Removes the Study Drug

RE-THINc ESRD
Start date: September 4, 2020
Phase: Phase 2
Study type: Interventional

Patients whose kidneys are no longer able to work as they should and require treatment to filter wastes from the blood (hemodialysis) are at high risk for blood clots that form in blood vessels (thrombosis) blocking blood flow that causes heart attacks, strokes, and other life-threatening conditions. BAY2976217 is under clinical development for prevention of thrombosis. The goal of the study is to learn more about the safety of BAY2976217, how it is tolerated and the way the body absorbs, distributes and gets rid of the study dug given as multiple doses in participants with renal impairment who require hemodialysis.

NCT ID: NCT04531462 Completed - Clinical trials for Diabetes Mellitus, Type 2

A Study to Test How Well Empagliflozin Works in Japanese People With Type 2 Diabetes Who Are Older Than 65 Years

Start date: October 5, 2020
Phase: Phase 4
Study type: Interventional

This study is to assess the efficacy of empagliflozin 10 mg after 52 weeks compared to placebo in elderly patients with Type 2 diabetes mellitus (T2DM) and to explore if empagliflozin has any impact on patient physical condition compared to placebo in elderly patients with T2DM.

NCT ID: NCT04530838 Completed - Clinical trials for Pneumococcal Disease

20-valent Pneumococcal Conjugate Vaccine Safety and Immunogenicity Study in Healthy Japanese Infants

Start date: September 16, 2020
Phase: Phase 3
Study type: Interventional

20-valent Pneumococcal Conjugate Vaccine Safety and Immunogenicity Study in Healthy Japanese Infants

NCT ID: NCT04527081 Completed - COVID-19 Clinical Trials

Study of COVID-19 DNA Vaccine (AG0302-COVID19)

Start date: August 31, 2020
Phase: Phase 1/Phase 2
Study type: Interventional

This study will assess the safety and immunogenicity of AG0302-COVID19 in healthy adult volunteers.