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NCT ID: NCT02394795 Completed - Colorectal Cancer Clinical Trials

Panitumumab and RAS, Diagnostically-useful Gene Mutation for mCRC

PARADIGM
Start date: May 29, 2015
Phase: Phase 3
Study type: Interventional

The purpose of this study is to verify the efficacy of mFOLFOX6 + panitumumab combination therapy and mFOLFOX6 + bevacizumab combination therapy in first-line treatment of chemotherapy-naive patients with KRAS/NRAS wild-type, incurable/unresectable, advanced/recurrent colorectal cancer.

NCT ID: NCT02391038 Completed - Clinical trials for Gastroesophageal Junction Adenocarcinoma

MLN0264 in Previously Treated Asian Patients With Advanced Gastrointestinal Carcinoma or Metastatic or Recurrent Gastric or Gastroesophageal Junction Adenocarcinoma Expressing Guanylyl Cyclase C

Start date: January 2015
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this study is to evaluate the effects of MLN0264 in previously treated Asian patients with Advanced Gastrointestinal (GI) Carcinoma (Phase 1) or Metastatic or Recurrent Gastric or Gastroesophageal Junction Adenocarcinoma (Phase 2) Expressing Guanylyl Cyclase C (GCC).

NCT ID: NCT02390050 Completed - Clinical trials for Diabetes Mellitus, Type 2

A Dose Range Finding Study to Evaluate the Effect of Bexagliflozin Tablets in Subjects With Type 2 Diabetes Mellitus

Start date: May 12, 2015
Phase: Phase 2
Study type: Interventional

The purpose of this study was to investigate the effect of bexagliflozin in lowering hemoglobin A1c (HbA1c) levels in patients with type 2 diabetes mellitus (T2DM). Bexagliflozin is an orally administered drug for the treatment of T2DM and is classified as a Sodium Glucose co-Transporter 2 (SGLT2) Inhibitor. This study was to enroll both treatment naive and those subjects previously treated with one oral hypoglycemic agent (OHA). Approximately 320 subjects eligible for randomization was to receive bexagliflozin tablets, 5, 10, 20 mg or placebo, once daily for 12 weeks in an outpatient setting.

NCT ID: NCT02389816 Completed - Clinical trials for Major Depressive Disorder

A Phase 3 Study of Lu AA21004 in Patients With Major Depressive Disorder

Start date: April 10, 2015
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the efficacy of two fixed doses of vortioxetine (Lu AA21004; 10 or 20 mg/day) after 8 weeks of treatment in patients with major depressive disorder (MDD) in Japan.

NCT ID: NCT02389790 Completed - Crohn's Disease Clinical Trials

Extension Study of MT-1303 in Subjects With Crohn's Disease

Start date: August 2015
Phase: Phase 2
Study type: Interventional

The primary objectives of the study are: -To evaluate the long-term safety and tolerability of MT-1303 in subjects with moderate to severe active Crohn's Disease(CD)

NCT ID: NCT02387996 Completed - Clinical trials for Various Advanced Cancer

A Study of Nivolumab in Participants With Metastatic or Unresectable Bladder Cancer

Start date: March 9, 2015
Phase: Phase 2
Study type: Interventional

The purpose the study is to measure the effect of nivolumab (BMS-936558) in reducing tumor size in subjects with metastatic or unresectable bladder cancer.

NCT ID: NCT02385994 Completed - Melasma Clinical Trials

A Prospective Multi-Center Study Using Laser for the Treatment of Melasma and Lentigines in Asian Skin

Start date: April 2015
Phase: N/A
Study type: Interventional

The purpose of this investigation is to evaluate safety and efficacy of the Cutera enlighten dual-pulse duration, dual-wavelength 532nm KTP/1064nm Nd:YAG laser for the treatment of melasma and lentigines on the face in Asian skin.

NCT ID: NCT02382939 Completed - Clinical trials for Adult Growth Hormone Deficiency

A Trial to Compare the Safety of Once Weekly Dosing of Somapacitan With Daily Norditropin® FlexPro® for 26 Weeks in Previously Human Growth Hormone Treated Adults With Growth Hormone Deficiency

REAL 2
Start date: February 12, 2015
Phase: Phase 3
Study type: Interventional

This trial is conducted in Europe and Asia. The aim of the trial is to compare the safety of once weekly dosing of somapacitan (administered with an investigational pen) with daily Norditropin® FlexPro® (somatropin delivered within a prefilled pen) for 26 weeks in previously human growth hormone (hGH) treated adults with growth hormone deficiency.

NCT ID: NCT02382796 Completed - NSCLC Clinical Trials

A Rollover Protocol of Dacomitinib For Patients In Japan

Start date: July 10, 2015
Phase: Phase 2
Study type: Interventional

The purpose of this study to permit continued access to dacomitinib for patients who participated in other dacomitinib monotherapy treatment protocols in Japan and have the potential to derive clinical benefit without unacceptable toxicity from continued dacomitinib treatment.

NCT ID: NCT02382276 Completed - Alcohol Dependence Clinical Trials

A Long-term Extension Study for the Phase 3 Study of Nalmefene (339-14-001) in Patients With Alcohol Dependence

Start date: July 13, 2015
Phase: Phase 3
Study type: Interventional

The long-term safety and efficacy of nalmefene hydrochloride at 20 mg in patients with alcohol dependence will be evaluated in a multicenter, open-label, uncontrolled trial.