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NCT ID: NCT03810222 Recruiting - Clinical trials for Brain Injuries, Traumatic

A Prospective Outcome Study in Patients With Moderate to Severe Traumatic Brain Injury

TBI-PRO
Start date: January 18, 2017
Phase:
Study type: Observational

Traumatic brain injury (TBI) is the leading cause of death, disability and cognitive impairment in young people worldwide. The majority of the traumatic deaths in developed countries results directly from lesions in the central nervous system. Furthermore, due to the persistence of disabling effects of TBI for many years, personal and public costs of supporting survivors have to be taken in consideration. Many patients rescued by ICU treatment may have been severely disabled or vegetative because of trauma. These data suggest that, despite improvement in medical and surgical treatments, other factors related to trauma itself and to patient's condition could have an impact on the final outcome. Aim of the TBI-PRO project is to collect high quality clinical and epidemilogical data and to describe the outcome of moderate-to-severe TBI in a local contest (Bergamo area, Italy).

NCT ID: NCT03810118 Not yet recruiting - Anesthesia, General Clinical Trials

Intraoperative Fluid Responsiveness After Mini Fluid Challenge.

REFILL
Start date: March 1, 2019
Phase: N/A
Study type: Interventional

It is unclear if the rate of administration of the fluid challenge could affect the rate of fluid responsiveness. The role of this small-dose (the so called mini-FC) has been recently tested to assess if the infusion of a small amount of fluids (100 ml in 1 minute) could predict the final effect of the residual aliquot (i.e., 250 ml of FC test subdivided as follows: 100 ml in 1 minute and 150 ml in 9 minutes). Both the sudden increase in the stroke volume and the reduction of PPV and SVV after a bolus of 100 ml of crystalloids administered in 1 minute showed high sensitivity and specificity in predicting the final outcome of the FC. The primary aim of the present study is assess whether the does the rate of infusion of fluid challenge affect fluid responsiveness in neurosurgical supine patients. The secondary aim is to assess the reliability of the changes in SV, PPV and SVV after a mini-FC test in predicting the final fluid responsiveness.

NCT ID: NCT03809429 Not yet recruiting - Infertility, Female Clinical Trials

Follitropin Delta in Long GnRH Agonist and GnRH Antagonist Protocols (BEYOND)

BEYOND
Start date: February 2019
Phase: Phase 3
Study type: Interventional

To compare the efficacy and safety of FE 999049 (follitropin delta) and its personalized dosing algorithm in controlled ovarian stimulation for in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) using a long gonadotropin-releasing hormone (GnRH) agonist protocol versus a short GnRH antagonist protocol.

NCT ID: NCT03809325 Recruiting - Schizophrenia Clinical Trials

A Survey to Collect Treatment Experience Feedback From Patients, Physicians, Nurses and Carers After Switching to Paliperidone Palmitate 3-monthly

Start date: November 21, 2018
Phase:
Study type: Observational

The purpose of this study is to explore the experience with paliperidone palmitate 3-month formulation (PP3M) treatment of participants and their corresponding physicians, nurses and carers, to understand the impact of less frequent injections from their perspective.

NCT ID: NCT03808753 Not yet recruiting - Surgery Clinical Trials

Mini Fluid chAlleNge and End-expiratory Occlusion Test and to Assess flUid responsiVEness in opeRating Room

MANEUVER
Start date: March 1, 2019
Phase: N/A
Study type: Interventional

End-expiratory occlusion test (EEOT) has been previously successfully tested in surgical patients, consisting of the interruption of the mechanical ventilation for 30 seconds, and in the evaluation of the changes in the SV. The mini fluid challenge test (mFC) aims at testing the increase in SV after the rapid administration of a small aliquot of the predefined FC. Both these test have been previously evaluated in small-sized studies and never compared each other.

NCT ID: NCT03808207 Recruiting - Breastfeeding Clinical Trials

Human Milk Lipid Profile Assessment and Influences of Mother's Diet

Start date: August 6, 2018
Phase: N/A
Study type: Interventional

Human milk profile is unique and diet exerts a pivot role in determing its composition. As a rule, nursing mothers do not receive specific nutritional indications aimed at improving the lipid profile of milk, despite the scientific evidence in favor of the importance of DHA in the infant's diet. The research aims to determine the effect of a dietary counseling specifically targeted at increasing the intake of fatty acids ω3 (DHA, EPA and ALA) on the lipid profile of breast milk, in order to identify effective and viable nutrition claims for breastfeeding women.

NCT ID: NCT03807947 Not yet recruiting - Clinical trials for Hepatocellular Carcinoma

Radial Versus Femoral Access for Superselective Embolization of Hepatocellular Carcinoma

Start date: January 2019
Phase: N/A
Study type: Interventional

The aim of this prospective, randomized study is to compare TRA vs TFA for superselective embolization of HCC using bland microparticles performed by multiple operators. In particular, main objectives are to compare: 1. the success rates of TRA and TFA including crossing over events between techniques 2. the inter-operator outcomes in terms of time to complete the vascular access and the vessel catheterization 3. access-related adverse events 4. patient preference and reported discomfort

NCT ID: NCT03807687 Recruiting - Clinical trials for Pancreatic Neoplasms

Registry of Pancreatic Disease

PAD-R
Start date: December 1, 2016
Phase:
Study type: Observational [Patient Registry]

This clinical data registry records information about the health status and healthcare performances received by participants affected by every type of pancreatic disease or disorder. All data (demographic, clinical, biochemical, radiological, pharmacological, genetic...) and audio and/or video recording from operative room are collected in order to be used for prospective or retrospective studies.

NCT ID: NCT03806816 Recruiting - Clinical trials for Hypoxic-Ischemic Encephalopathy

Use of Melatonin for Neuroprotection in Asphyxiated Newborns

MELPRO
Start date: December 13, 2018
Phase: N/A
Study type: Interventional

Protection of brain development is a major aim in the Neonatal Intensive Care Unit. Hypoxic-Ischemic Encephalopathy (HIE) occurs in 3-5 per 1000 births. Only 47% of neonates have normal outcomes. The neurodevelopmental consequences of brain injury for asphyxiated term infants include cerebral palsy, severe intellectual disabilities and also a number of minor behavioural and cognitive deficits. However, there are very few therapeutic strategies for the prevention or treatment of brain damage. The gold standard is hypotermic treatment but, according to the literature, melatonin potentially acts in synergy with hypothermia for neuroprotection and to improve neurologic outcomes. Melatonin appears to be a good candidate because of its different protective effects including reactive oxygen species scavenging, excitotoxic cascade blockade, modulation of neuroinflammatory pathways. The research study will evaluate the neuroprotective properties and the effects of Melatonin in association with therapeutic hypothermia for hypoxic ischemic encephalopathy.

NCT ID: NCT03806426 Recruiting - Clinical trials for Familial Adenomatous Polyposis

Effect of EPA-FFA on Polypectomy in Familial Adenomatous Polyposis

Start date: December 5, 2018
Phase: Phase 3
Study type: Interventional

The purpose of this Phase III study is to determine whether Eicosapentaenoic acid-free fatty acid is a safe and well tolerated treatment in reducing the number of polypectomies FAP patients with an APC gene mutation have over a 2 year treatment period and to assess the effect that this has on clinical disease progression.