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NCT ID: NCT03176732 Recruiting - Hypertension Clinical Trials

Mechanisms for Individual Differences in Hypertension in Obstructive Sleep

PISA-BP
Start date: June 6, 2017
Phase: N/A
Study type: Observational

Hypertension is a common consequence of obstructive sleep apnea (OSA). However, not all individuals with OSA have hypertension and there are major individual differences in blood pressure response to positive airway pressure treatment of OSA. This project is focused on determining the basis of these individual differences in blood pressure response to OSA and will evaluate the possible underlying reasons for these differences. The results will help clinicians to know whether or not to expect a reduction in blood pressure (BP) to OSA treatment in a given patient and thereby personalize patient management.

NCT ID: NCT03174002 Recruiting - Oxygen Toxicity Clinical Trials

Handling Oxygenation Targets in the Intensive Care Unit

HOT-ICU
Start date: June 19, 2017
Phase: Phase 4
Study type: Interventional

Handling oxygenation targets (HOT) is standard of care in the intensive care unit (ICU), however the quality and quantity of evidence is low and potential harm has been reported. The aim of the HOT-ICU trial is to assess the overall benefits and harms of two levels of oxygenation targets in adult critically ill patients with acute hypoxaemic respiratory failure in the ICU.

NCT ID: NCT02826603 Recruiting - Plaque Psoriasis Clinical Trials

Study of Secukinumab Compared to Ustekinumab in Subjects With Plaque Psoriasis

CLARITY
Start date: June 2016
Phase: Phase 3
Study type: Interventional

Demonstrate superiority of secukinumab over ustekinumab in treatment of moderate to severe plaque psoriasis.

NCT ID: NCT02825134 Recruiting - Clinical trials for Cardiovascular Diseases

Comparison of Transcatheter Versus Surgical Aortic Valve Replacement in Younger Low Surgical Risk Patients With Severe Aortic Stenosis

NOTION-2
Start date: June 2016
Phase: N/A
Study type: Interventional

A randomized clinical trial investigating transcatheter (TAVR) versus surgical (SAVR) aortic valve replacement in patients 75 years of age or younger suffering from severe aortic valve stenosis. Study hypothesis: The clinical outcome (composite endpoint of all-cause mortality, MI and stroke) obtained within 1 year after TAVR is non-inferior to SAVR.

NCT ID: NCT02780297 Recruiting - Hyperoxaluria Clinical Trials

Prospective Research Rare Kidney Stones (ProRKS)

ProRKS
Start date: May 2016
Phase: N/A
Study type: Observational

The purpose of this study is to determine the natural history of the hereditary forms of nephrolithiasis and chronic kidney disease (CKD), primary hyperoxaluria (PH), cystinuria, Dent disease and adenine phosphoribosyltransferase deficiency (APRTd) and acquired enteric hyperoxaluria (EH). The investigator will measure blood and urinary markers of inflammation and determine relationship to the disease course. Cross-comparisons among the disorders will allow us to better evaluate mechanisms of renal dysfunction in these disorders.

NCT ID: NCT02752633 Completed - Clinical trials for Adenine Phosphoribosyltransferase Deficiency

Effect of Allopurinol and Febuxostat on Urinary 2,8-Dihydroxyadenine Excretion

Start date: May 2013
Phase: Phase 4
Study type: Interventional

This exploratory pilot study was an open-label, crossover, single-center and non-randomized clinical trial designed to compare the effect of the standardly employed doses of allopurinol (400 mg/day) and febuxostat (80 mg/day) on the urinary 2,8-dihydroxyadenine (DHA) excretion in patients with adenine phosphoribosyltransferase (APRT) deficiency.

NCT ID: NCT02748863 Recruiting - Psoriasis Clinical Trials

Study of Secukinumab With 2 mL Pre-filled Syringes

ALLURE
Start date: December 2, 2016
Phase: Phase 3
Study type: Interventional

The aim of the study is to demonstrate efficacy, safety and tolerability of 2 mL pre-filled syringe of 300 mg secukinumab in treatment of moderate to severe plaque psoriasis.

NCT ID: NCT02705664 Completed - Foot Dermatoses Clinical Trials

Treatment of Onychomycosis With Loceryl (Amorolfine) Nail Lacquer 5% Versus a Two-course Treatment With Urea 40% Ointment and Bifonazole Cream 1%

OPEN
Start date: January 2016
Phase: Phase 4
Study type: Interventional

The main objective of this study is to compare subject adherence and satisfaction for two modes of treatment toenails infection (Onychomycosis) with Loceryl Nail Lacquer (Loceryl NL) and a Fungal Nail Treatment Set containing Urea 40% ointment (Urea) and Bifonazole cream 1% (Bifonazole).

NCT ID: NCT02699736 Enrolling by invitation - Clinical trials for Cardiovascular Diseases

Clinical and Virological Outcome of European Patients Infected With HIV

EuroSIDA
Start date: January 1994
Phase: N/A
Study type: Observational [Patient Registry]

The EuroSIDA study is a prospective observational cohort study of 20,000+ patients followed in 100+ clinics in 35 European countries, Israel and Argentina. The study is the largest pan-European cohort study and few studies of a comparable design are available on a global scale. The EuroSIDA study is an ongoing collaboration and patients have been enrolled into the study through 10 cohorts since 1994. The main objective of the study remains the same as in1994: to prospectively study, clinical, therapeutic, demographic, virological and laboratory data from HIV-1 positive persons across Europe in order to determine their long-term virological, immunological and clinical outcomes. Historically, EuroSIDA has been crucial in reporting key changes in the HIV epidemic, such as the dramatic changes in morbidity and mortality when combination anti-retroviral therapy (cART) was first introduced. As new anti-HCV treatment is introduced to HIV/HCV co-infected patients, it is important for EuroSIDA to remain in the forefront of investigating the treatment benefits and adverse effects. All study documents, study status, newsletters, scientific publications and presentations are available online and are updated continuously at project website. In general terms, the objective of the EuroSIDA study is to continue a long-term, prospective collection of clinical, laboratory and therapeutic data as well as plasma on a large cohort of consecutive HIV infected patients from across Europe in order to (1) assess the factors associated with the clinical, immunological and virological course of HIV infection and HIV-related co-infections and co-morbidities, and (2) continue to provide and develop a surveillance system to describe temporal changes and regional differences in the clinical course of HIV and HIV-related co-infections and co-morbidities in Europe.

NCT ID: NCT02682212 Recruiting - Clinical trials for Pregnancy Complications

Obstetric Perineal Trauma and Physiotherapy

Start date: March 2016
Phase: N/A
Study type: Interventional

The main objective is to investigate effects of perineal trauma at birth on women´s health and whether early physiotherapy improves pelvic floor strength. This will be achieved by an acknowledged/validated questionnaire sent electronically 6 weeks after first delivery. Women with symptomes of urinary incontinence according to the questionnaire will be offered participation in a single-blinded randomized intervention study to compare outcome after targeted physiotherapy with conventional advice and support. Intervention encompasses weekly pelvic floor training for 12 weeks. Pelvic strength will be measured and symptom information collected before and after intervention and 12 months postpartum in both groups. Pelvic floor problems after delivery are common and often persistent, including urinary/fecal incontinence, pelvic organ prolapse and sexual problems. Such symptoms reduce QoL and handicap women in multiple ways, physically, psychologically and socially. More knowledge of whether interventions and guidelines in this field can improve health and QoL is required.