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NCT ID: NCT04003103 Completed - HIV-1 Infection Clinical Trials

Safety and Pharmacokinetics of Oral Islatravir (MK-8591) Once Monthly in Participants at Low Risk of Human Immunodeficiency Virus 1 (HIV-1) Infection (MK-8591-016)

Start date: September 19, 2019
Phase: Phase 2
Study type: Interventional

This study will evaluate the safety, tolerability and pharmacokinetics (PK) of 6 once-monthly doses of oral islatravir (60 mg and 120 mg) compared with placebo in adults at low risk of HIV-1 infection

NCT ID: NCT04002830 Completed - Clinical trials for Gaucher Disease, Type 3

A Multicenter, Safety and Efficacy Study of Taliglucerase Alfa in Subjects With Type 3 Gaucher Disease

Start date: November 20, 2020
Phase: Phase 4
Study type: Interventional

This is a multicenter study to assess the safety and efficacy of taliglucerase alfa (60 units/kg) in previously untreated subjects of any age with Type 3 GD. Subjects will receive an infusion of taliglucerase alfa every 2 weeks for 12 months. Subjects who tolerate the infusions well, and who are treated in centers where home therapy is the SOC will be allowed to switch from site to home treatment at the discretion of the PI but after no less than 3 uneventful infusions at the site.

NCT ID: NCT03996369 Completed - Ulcerative Colitis Clinical Trials

Etrasimod Versus Placebo as Induction Therapy in Moderately to Severely Active Ulcerative Colitis

ELEVATE UC 12
Start date: September 15, 2020
Phase: Phase 3
Study type: Interventional

The purpose of this study is to assess the efficacy of etrasimod on clinical remission in participants with moderately to severely active ulcerative colitis (UC).

NCT ID: NCT03991455 Completed - Clinical trials for Pelvic Organ Prolapse

Evaluation of Safety and Efficacy of the Apyx™ Device for the Repair of Pelvic Organ Prolapse (POP)

Start date: October 25, 2019
Phase: N/A
Study type: Interventional

The aim of this study is to further evaluate this minimally invasive SSLF technique with respect to safety, clinical effectiveness, and patient satisfaction. The procedure will be performed in women electing to undergo surgical repair of their prolapse who wish to preserve their uterus, and will be evaluated using standardized measures and questionnaires.

NCT ID: NCT03990363 Completed - Clinical trials for Chronic Kidney Disease

A Study of Verinurad and Allopurinol in Patients With Chronic Kidney Disease and Hyperuricaemia

SAPPHIRE
Start date: July 23, 2019
Phase: Phase 2
Study type: Interventional

The purpose of this clinical research study is to establish the dose of verinurad combined with allopurinol 300 mg once daily that will elicit the desired response; ie, reduction in urinary albumin to creatinine ratio (UACR) at 6 months.

NCT ID: NCT03989180 Completed - Colo-rectal Cancer Clinical Trials

Development Study of Check-Cap Imaging System in Healthy Volunteers

Start date: January 6, 2016
Phase:
Study type: Observational [Patient Registry]

To evaluate the performance of Check-Cap Imaging System in healthy volunteers in a variety of operating scenarios. The Back recorder unit is the primary module for evaluation The participants DO NOT ingest a capsule and the capsules do not have any radioactive source

NCT ID: NCT03987919 Completed - Type 2 Diabetes Clinical Trials

A Study of Tirzepatide (LY3298176) Versus Semaglutide Once Weekly as Add-on Therapy to Metformin in Participants With Type 2 Diabetes

SURPASS-2
Start date: July 30, 2019
Phase: Phase 3
Study type: Interventional

The reason for this study is to compare the effect of the study drug tirzepatide to semaglutide on blood sugar levels in participants with type 2 diabetes. The study will last approximately 47 weeks and may include about 12 visits.

NCT ID: NCT03982589 Completed - Acute Disease Clinical Trials

Telomere Length in Relation to Acute Stress Response in Critical Care Patients

Start date: October 1, 2017
Phase:
Study type: Observational [Patient Registry]

the investigators studied the impact of severe stress (in this case any event or illness leading to a necessity of critical care) on telomere length.

NCT ID: NCT03979313 Completed - Clinical trials for Respiratory Syncytial Virus Infections

A Study to Evaluate the Safety and Efficacy of MEDI8897 for the Prevention of Medically Attended Lower Respiratory Tract Infection Due to Respiratory Syncytial Virus in Healthy Late Preterm and Term Infants (MELODY)

MELODY
Start date: July 23, 2019
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the efficacy, safety, pharmacokinetics (PK), and antidrug antibody (ADA) response for MEDI8897 in healthy late preterm and term infants who are 35 weeks or greater gestational age and entering their first RSV season.

NCT ID: NCT03978507 Completed - Parkinson Disease Clinical Trials

Digital Wearable Walking Aid for Freezing of Gait in Parkinson´s Disease

Start date: June 13, 2019
Phase: N/A
Study type: Interventional

The objective of this study is to investigate the effects of relatively long-term use of a wearable device that provides personalized and intelligent cues (e.g. only when FOG is detected) on FOG.