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NCT ID: NCT02463097 Completed - Type 1 Diabetes Clinical Trials

Hybrid Closed Loop Pivotal Trial in Type 1 Diabetes

Start date: June 2015
Phase: N/A
Study type: Interventional

This study is a single-arm, multi-center, Home and Hotel Clinical Investigation in subjects with type 1 diabetes on insulin pump therapy. The purpose of this study is to demonstrate that the closed loop algorithm that is built into the 670G insulin pump is safe as part of the overall system.

NCT ID: NCT02463058 Completed - Clinical trials for Physiological Stress

Evaluating the Physiological Strain Induced by a BC Protective Undergarment Under Exercise-heat Stress

Start date: August 2015
Phase: N/A
Study type: Interventional

Israel ministry of defense is examining a new protective undergarment of GORE company (chempark fabric) for the police forces. The goal of this research is to perform a comparative experiment in order to evaluate the physiological strain induced by a BC protective undergarment under exercise-heat stress conditions.

NCT ID: NCT02462928 Completed - Clinical trials for Macular Degeneration

A Safety and Efficacy Study of Abicipar Pegol in Participants With Neovascular Age-related Macular Degeneration

CEDAR
Start date: June 25, 2015
Phase: Phase 3
Study type: Interventional

This is a safety and efficacy study of abicipar pegol in participants with neovascular age-related macular degeneration.

NCT ID: NCT02460536 Completed - Anxiety Disorders Clinical Trials

Attention Bias Modification Treatment (ABMT) for Anxiety Disorders in Youth

Start date: May 2015
Phase: N/A
Study type: Interventional

Attention biases in threat processing have been assigned a prominent role in the etiology and maintenance of anxiety disorders. Attention Bias Modification Treatment (ABMT) utilizes computer-based protocols to implicitly modify biased attentional patterns in anxious patients. This is a double-blind randomized controlled trial of ABMT for clinically anxious 10-18 year-olds. Participants will be assessed using clinical interviews and parent- and self-rated questionnaires before, in the middle and after twelve sessions of ABMT or control groups, and again at ten-week follow-up. Outcome measures will be anxiety symptoms and depression as measured by gold standard questionnaires as well as structured clinical interviews with youth and their parents. Attentional threat bias, Attentional control and interpretation of ambiguous information will also be measured to explore potential mediators of ABMT's effect on anxiety. The investigators expect the findings to inform pathways to treatments for anxious children and to provide initial information on mechanisms of ABMT efficacy.

NCT ID: NCT02459600 Recruiting - General Anesthesia Clinical Trials

Comparison of Refraction Measurments in Children Under General Anesthesia, With and Without Cycloplegic Drops

Start date: May 2015
Phase: Phase 0
Study type: Interventional

Assessment of refraction measurements in children under general anesthesia, with or without cyclopelgic eye-drops

NCT ID: NCT02458625 Completed - Postpartum Anemia Clinical Trials

A Comparison Between Intravenous Iron Sucrose to Its Combination With Oral Iron Supplements for the Treatment of Postpartum Anemia

Start date: April 2016
Phase: N/A
Study type: Interventional

This study is aimed to compare the efficacy of two mode of iron administration to treat post partum anemia - a single dose of intravenous iron sucrose versus a single dose of iron sucrose and 6 weeks of treatment with oral iron supplement.

NCT ID: NCT02456103 Terminated - Cystic Fibrosis Clinical Trials

Extension Study of Ataluren in Participants With Nonsense Mutation Cystic Fibrosis

Start date: August 31, 2015
Phase: Phase 3
Study type: Interventional

This is an open-label extension study for participants who completed a Phase 3, placebo-controlled study of ataluren in participants with nonsense mutation cystic fibrosis (nmCF) not receiving chronic inhaled aminoglycosides.

NCT ID: NCT02454283 Terminated - Clinical trials for Atrial Fibrillation or Flutter

Safety and Efficacy of Vanoxerine for the Conversion of Subjects With Recent Onset Atrial Fibrillation or Flutter to Normal Sinus Rhythm

RESTORE SR
Start date: September 2015
Phase: Phase 3
Study type: Interventional

LGN-VN-003 is a prospective, multi-center, randomized, double-blind, placebo-controlled study to evaluate the safety and efficacy of a single oral dose of vanoxerine for the conversion of subjects with recent onset atrial fibrillation (AF) or atrial flutter (AFL) to normal sinus rhythm. Up to 625 subjects will be randomized in a 2:1 fashion so at least 400 vanoxerine and 200 placebo subjects receive study drug.

NCT ID: NCT02454270 Terminated - Clinical trials for Lymphoma, Large B-Cell, Diffuse

A Dose Escalation Study of Duvortuxizumab in Participants With Relapsed or Refractory B-cell Malignancies

Start date: June 15, 2015
Phase: Phase 1
Study type: Interventional

The purpose of this study is to evaluate the safety, tolerability, dose-limiting toxicities (any harmful effect of a drug) (DLT), maximum tolerated dose (MTD), recommended Phase 2 dose (RP2D) and preliminary clinical activity of duvortuxizumab when administered intravenously to participants with relapsed or refractory B-cell malignancies [diffuse-large B cell lymphoma (DLBCL), follicular lymphoma (FL), mantle-cell lymphoma (MCL), chronic lymphocytic leukemia (CLL), and acute lymphoblastic leukemia (ALL)].

NCT ID: NCT02453711 Completed - Obesity Clinical Trials

Investigation of Safety and Efficacy of Once-daily Semaglutide in Obese Subjects Without Diabetes Mellitus

Start date: October 1, 2015
Phase: Phase 2
Study type: Interventional

This trial is conducted globally. The aim of this trial is to investigate safety and efficacy of once-daily semaglutide in obese subjects without diabetes mellitus.