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NCT ID: NCT02855944 Completed - Ovarian Cancer Clinical Trials

ARIEL4: A Study of Rucaparib Versus Chemotherapy BRCA Mutant Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Patients

Start date: March 1, 2017
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine how patients with ovarian, fallopian tube, and primary peritoneal cancer will best respond to treatment with rucaparib versus chemotherapy.

NCT ID: NCT02854878 Completed - Pediculus Capitis Clinical Trials

Treatment of Head Lice Infestation Using Novel Ultrasonic Comb

Start date: November 28, 2016
Phase: N/A
Study type: Interventional

A pilot study to evaluate safety and efficacy of the Lucy combined with LucyGel in killing head lice and their eggs. 23 participants will be enrolled in this study. The first 12 will be combed with model A and the remaining 11 will be combed with model B

NCT ID: NCT02854436 Completed - Prostatic Neoplasms Clinical Trials

An Efficacy and Safety Study of Niraparib in Men With Metastatic Castration-Resistant Prostate Cancer and DNA-Repair Anomalies

Galahad
Start date: August 31, 2016
Phase: Phase 2
Study type: Interventional

The purpose of this study is to assess the efficacy, safety, and pharmacokinetics of niraparib in men with metastatic castration-resistant prostate cancer (mCRPC) and deoxyribonucleic acid (DNA) repair anomalies.

NCT ID: NCT02851797 Completed - Clinical trials for Duchenne Muscular Dystrophy

Clinical Study to Evaluate the Efficacy and Safety of Givinostat in Ambulant Patients With Duchenne Muscular Dystrophy

Start date: June 6, 2017
Phase: Phase 3
Study type: Interventional

Primary Objective The primary objective of the study was to establish the effects of givinostat versus placebo administered chronically over 18 months to slow disease progression in ambulant DMD subjects. Secondary Objectives The secondary objectives of this study were: - To assess the safety and tolerability of givinostat versus placebo administered chronically in DMD subjects - To evaluate the PK profile of givinostat administered chronically in DMD subjects - To evaluate the impact on quality of life (QoL) and activities of daily living of givinostat versus placebo administered chronically.

NCT ID: NCT02851407 Completed - Clinical trials for Veno-occlusive Disease

Study Comparing Efficacy and Safety of Defibrotide vs Best Supportive Care in the Prevention of Hepatic Veno-Occlusive Disease in Adult and Pediatric Patients

Start date: September 1, 2016
Phase: Phase 3
Study type: Interventional

This study is to compare the efficacy and safety of defibrotide prophylaxis in addition to best supportive care versus best supportive care alone in the prevention of hepatic veno- occlusive disease (VOD) in adult and pediatric patients undergoing hematopoietic stem cell transplant who are at high risk or very high risk of developing VOD.

NCT ID: NCT02851199 Recruiting - Epilepsy Clinical Trials

The Effect of Child Position on the Results of Hyperventilation During Routine Electroencephalography

Start date: July 2016
Phase: N/A
Study type: Interventional

Electroencephalograhy (EEG) is used as a tool for diagnosing epilepsy/convulsions. During the recording, especially for childen who are suspected of having abbcence epilepsy the investigators will perform an EEG recording including a provocation test of hyperventilation in order to induce epileptic discharges. There is no clear instruction about the position of the child during performing this hyperventilation provocation. Clinical observations showed that this provocation is more effective when it's performed in the siiting position. No study was previously performed to investigate this issue

NCT ID: NCT02850419 Withdrawn - Breast Cancer Clinical Trials

Heat-Activated Target Therapy of Local-Regional Relapse in Breast Cancer Patients

EURO-DIGNITY
Start date: March 2017
Phase: Phase 2
Study type: Interventional

The 105-15-201 study is designed to assess the effectiveness and tolerability of the combination of heat-activated target therapy (radiotherapy + hyperthermia + lyso-thermosensitive liposomal doxorubicin) of loco-regional relapse in breast cancer patients.

NCT ID: NCT02849977 Completed - Clinical trials for Pro-opiomelanocortin (POMC), Proprotein Convertase Subtilisin/Kexin Type 1 (PCSK1) and Leptin Receptor (LepR) Gene Mutations

Genetic Testing and Phenotypic Characterization of Severely Obese Pediatric and Adult Volunteers

Start date: September 28, 2016
Phase:
Study type: Observational

The purpose of this screening study is to identify people who have a rare genetic cause of obesity - specifically three genetic variants (a change in the DNA structure) of the POMC, PCSK1 and LepR genes that are currently known to result in obesity. This screening study will not include any investigational drugs. You will be asked to provide a DNA sample and answer some questions about your medical history and hunger.

NCT ID: NCT02848911 Terminated - Leukemia, B-Cell Clinical Trials

Safety Study to Assess AFM11 in Patients With Relapsed or Refractory Adult B-precursor ALL

Start date: October 2016
Phase: Phase 1
Study type: Interventional

The purpose of the study is to determine the maximum tolerated dose (MTD) in patients with acute lymphoblastic leukemia (ALL) and to determine the safety and tolerability of increasing doses and different infusion times of AFM11 infusion in patients with adult B-precursor ALL

NCT ID: NCT02847897 Completed - Exposure Laser Clinical Trials

Evaluation of Safety and Efficacy of Carbon Dioxide (CO2) Acupulse Laser Treatment on Vaginal Elasticity.

Start date: August 1, 2016
Phase: N/A
Study type: Interventional

The study is intended to assess the safety and efficacy of CO2 AcuPulse laser treatment in patients with vaginal prolapse. Eligible subjects will receive 3 treatment sessions, 4 weeks apart and 3 Follow Up visits, at 1, 3, and 6 months following the last treatment.