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NCT ID: NCT03681184 Not yet recruiting - Clinical trials for Primary Hyperoxaluria Type 1 (PH1)

Phase 3 Study to Evaluate the Efficacy and Safety of Lumasiran in Children and Adults With Primary Hyperoxaluria Type 1

ILLUMINATE-A
Start date: September 26, 2018
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the efficacy and safety of Lumasiran in Children and Adults with Primary Hyperoxaluria Type 1 (PH1).

NCT ID: NCT03681067 Not yet recruiting - Crohn Disease Clinical Trials

A Clinical Trial of Antibody GSK1070806 in the Treatment of Patients With Moderate to Severe Crohn's Disease

CDAID
Start date: September 2018
Phase: Phase 1/Phase 2
Study type: Interventional

This trial aims to investigate the safety, tolerability and clinical activity of humanised antibody GSK1070806 delivered via intravenous infusion in the treatment of patients with moderate-to-severe Crohn's disease. 30-36 patients will be enrolled into the trial, with two thirds of the patients receiving active drug and one third receiving placebo. After 30 patients have been recruited into the study the sample size will be reassessed and up to an additional 6 patients could be recruited (i.e. up to 36 patients).

NCT ID: NCT03680378 Recruiting - Healthy Subjects Clinical Trials

Lung Pharmacokinetics (PK) in Epithelial Lining Fluid (ELF)

Start date: July 1, 2017
Phase: Phase 1
Study type: Interventional

The primary objective of this study is to measure and compare the concentration of AAI101 and cefepime in bronchial epithelial lining fluid (ELF) and plasma following administration of cefepime/AAI101 combination in healthy subjects.

NCT ID: NCT03679533 Recruiting - Aging Clinical Trials

The Impact of Cranberries On the Microbiome and the Brain in Healthy Ageing sTudy (COMBAT)

COMBAT
Start date: October 1, 2018
Phase: N/A
Study type: Interventional

Tremendous progress has been made in characterizing the interactions between the central nervous system and the gastrointestinal tract. This concept of a gut-brain axis suggests that influencing bacteria in the gut is a promising approach for developing new ways of benefiting brain function. This is particularly relevant for an ageing population for which cognitive decline is a common symptom and can be an indicator for the development of neurodegenerative conditions such as dementia. There is good evidence already that nutrition can delay the development of cognitive decline in ageing, in particular for ageing-sensitive brain regions such as the medial temporal lobe, however this has been little explored for cranberry intake. Cranberries are high in plant-derived nutrients called polyphenols, which have been suggested to promote brain function and protect against disease-causing mechanisms. In the proposed project we will pioneer work to investigate the impact of cranberry intake on gut bacteria and how it relates to cognitive performance in ageing and associated regions in the brain. Sixty participants (i.e. n=30 control and treatment groups) in married couples aged 65-75yo, with no memory complaints will be recruited for this 12-week double-blind placebo-controlled parallel intervention of cranberry flavonoids. Freeze-dried cranberry or a matched placebo will be taken twice daily for the duration of the trial. Blood, urine and faecal samples will be collected for microbiome, DNA, biochemical and nutritional analysis. Participants will also undergo cognitive testing, as well as MRI scanning to detect changes in brain physiology.

NCT ID: NCT03679078 Active, not recruiting - Malnutrition Clinical Trials

IDDSI Nutritional Drink for Dysphagia Study

Start date: August 28, 2018
Phase: N/A
Study type: Interventional

This study will evaluate the gastrointestinal (GI) tolerance, compliance , acceptability and safety of a ready-to-use oral nutritional supplement drink for patients with dysphagia.

NCT ID: NCT03678714 Not yet recruiting - Clinical trials for Polycystic Ovary Syndrome

Effect of Exercise on Cardiometabolic Profile in Women With Polycystic Ovary Syndrome

Start date: October 2018
Phase: N/A
Study type: Interventional

Polycystic Ovary Syndrome (PCOS) is a complex hormonal and metabolic disorder that has been shown to affect women's fertility. It can also share many symptoms with pre-diabetes, and women with PCOS often have an increased risk for type 2 diabetes, heart attack and stroke. This study aims to assess the feasibility and acceptability of exercise intervention and increased lifestyle physical activity to improve cardiovascular disease risk factors in women with PCOS.

NCT ID: NCT03678636 Recruiting - Chronic Wounds Clinical Trials

WOUNDCHEK Bacterial Status Benefits Evaluation

Start date: July 30, 2018
Phase: N/A
Study type: Interventional

100 chronic wounds asymptomatic for infection that test positive for bacterial protease activity (BPA) on initial screening (approx 250 wounds in total to be tested) will be randomized to intervention or control. 50 patients will receive intervention (silver antimicrobial dressing) in addition to standard care and 50 will receive standard care only (control). Wound healing at 12 weeks will be compared in addition to costs, patient quality of life, referrals to secondary care, surgical interventions, rates of infection and antibiotic use.

NCT ID: NCT03678129 Recruiting - Clinical trials for Autism Spectrum Disorder

GABA Pathways in Autism Spectrum Disorder (ASD)

Start date: September 28, 2018
Phase: N/A
Study type: Interventional

This study investigates the brain response to a single acute dose of AZD7325, a GABA-A positive allosteric modulator, compared to a single dose of placebo in adults with and without autism spectrum disorder.

NCT ID: NCT03677687 Active, not recruiting - Physical Activity Clinical Trials

Mindfulness for Physical Activity Research Project

Start date: September 17, 2018
Phase: N/A
Study type: Interventional

This study aims to evaluate the feasibility and preliminary effectiveness of a Mindfulness for Physical Activity programme on physical activity outcomes in underactive participants.

NCT ID: NCT03677635 Active, not recruiting - Psychosis Clinical Trials

The Relationship Between Autobiographical Memory and Motivation

Start date: May 18, 2017
Phase: N/A
Study type: Interventional

People with a diagnosis of psychosis often experience low motivation and pleasure when thinking about doing future activities. This leads, quite understandably, to doing fewer activities they used to enjoy and not taking up opportunities to do new activities. One model suggests that this may be partly due to difficulties using memories of previous events to help boost motivation and anticipation before a future activity. Research shows that people with psychosis may recall previous events in less detail. These memories therefore may not be as helpful as they could be for motivation. This study will investigate this by asking people with experience of psychosis and low motivation who are seen by a care team in South London and Maudsley NHS Trust to attend two research sessions. In the first session they will be asked to recall memories of events from their lives and the researcher will assess how detailed they are and how much they refer to the past and future. Alongside this task people will also be asked to complete measures of symptoms such as low pleasure and motivation as well as a measure of depression. These will be used to find out if the detail and specificity of the memories are related to these symptoms in people with psychosis. The second half of the study will then investigate whether additional prompts to support positive memory retrieval can increase the specificity of this and subsequently improve mood, motivation and self-belief. Participants will be randomised to one of two groups. The clinical group will be guided through their memory recall using prompts and a control group will be asked to recall positive memories without prompts. If we show that supporting memory recall is beneficial then memories for past events may be an important target for future therapies.