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NCT ID: NCT00936260 Completed - Osteoporosis Clinical Trials

Drug Holidays in the Treatment With Alendronate in Postmenopausal Women With Osteoporosis

Start date: January 1998
Phase: N/A
Study type: Interventional

The purpose of this study is to determine the duration of the treatment with alendronate in postmenopausal women with osteoporosis.

NCT ID: NCT00936221 Completed - Melanoma Clinical Trials

Comparison of AZD6244 in Combination With Dacarbazine Versus (vs) Dacarbazine Alone in BRAF Mutation Positive Melanoma Patients

Start date: July 2009
Phase: Phase 2
Study type: Interventional

To assess the efficacy in terms of overall survival of AZD6244 in combination with dacarbazine, compared with dacarbazine alone, in first line patients with BRAF mutation positive advanced cutaneous or unknown primary melanoma

NCT ID: NCT00934856 Completed - Breast Cancer Clinical Trials

A Study of Trastuzumab Emtansine (T-DM1) in Combination With Docetaxel, and Potentially Pertuzumab, in Patients With Advanced Breast Cancer

Start date: July 2009
Phase: Phase 1
Study type: Interventional

This open-label, multi-center study will assess the safety and tolerability of adding trastuzumab emtansine (T-DM1) to docetaxel in patients with locally advanced or metastatic HER2-positive breast cancer. Patients will receive T-DM1 and docetaxel on Day 1 of each 3-week cycle. For patients with locally advanced breast cancer, pertuzumab may be added to trastuzumab emtansine and docetaxel. Anticipated time on study treatment is up to 6 cycles for patients with locally advanced breast cancer, until disease progression or unacceptable toxicity occurs for patients with metastatic breast cancer.

NCT ID: NCT00934544 Completed - Myelofibrosis Clinical Trials

Controlled Myelofibrosis Study With Oral Janus-associated Kinase (JAK) Inhibitor Treatment-II: The COMFORT-II Trial

Start date: July 1, 2009
Phase: Phase 3
Study type: Interventional

This was an open label, randomized study comparing the efficacy and safety of randomized 2:1 Ruxolitinib tablets versus best-available therapy, as selected by the investigator. The purpose was to compare the efficacy, safety and tolerability of Ruxolitinib (INC424/INCB018424) given twice daily to the best-available therapy, in subjects with primary myelofibrosis (PMF), post polycythemia vera myelofibrosis (PPV-MF) or post essential thrombocythemia myelofibrosis (PET-MF).

NCT ID: NCT00933686 Completed - Fibromyalgia Clinical Trials

Growth Hormone in Neuroendocrine Dysfunction With Severe Fibromyalgia Syndrome

Start date: December 2007
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the efficacy of recombinant human growth hormone (r-hGH) treatment in severe fibromyalgia subjects with growth axis dysfunction.

NCT ID: NCT00932893 Completed - Clinical trials for Carcinoma, Non-Small-Cell Lung

An Investigational Drug, PF-02341066 Is Being Studied Versus Standard Of Care In Patients With Advanced Non-Small Cell Lung Cancer With A Specific Gene Profile Involving The Anaplastic Lymphoma Kinase (ALK) Gene

Start date: September 2009
Phase: Phase 3
Study type: Interventional

This is a Phase 3 trial comparing the safety and anti-tumor activity of PF-02341066 versus pemetrexed or docetaxel in patients with advanced non-small cell lung cancer with specific gene profile involving the ALK gene after failure of one previous chemotherapy regimen that included one platinum drug.

NCT ID: NCT00932451 Completed - Clinical trials for Carcinoma, Non-Small-Cell Lung

An Investigational Drug, PF-02341066, Is Being Studied In Patients With Advanced Non-Small Cell Lung Cancer With A Specific Gene Profile Involving The Anaplastic Lymphoma Kinase (ALK) Gene

Start date: January 2010
Phase: Phase 2
Study type: Interventional

This is a Phase 2 trial that will evaluate the safety and efficacy of PF-02341066 in patients with advanced non-small cell lung cancer with a specific gene profile involving the ALK gene. This trial will also allow patients from a Phase 3 trial who received standard of care chemotherapy (Study A8081007) to receive PF-02341066.

NCT ID: NCT00931775 Completed - Clinical trials for Major Depressive Disorder

Citalopram Versus Citalopram Plus Pindolol in Major Depressive Disorder

CIT-PIN
Start date: December 2002
Phase: Phase 2
Study type: Interventional

The purpose of this study is to examine whether the speed of the clinical antidepressant action of citalopram can be accelerated by administering double doses of pindolol (15 mg/day, tid) which presumably should lead to increased 5-HT1A autoreceptor occupancy.

NCT ID: NCT00930982 Completed - Bronchiectasis Clinical Trials

Evaluation of Cipro Inhale in Patients With Non-cystic Fibrosis Bronchiectasis

Start date: June 2009
Phase: Phase 2
Study type: Interventional

The purpose of this study is to find out if bacterial load in the airways can be reduced after inhalation of ciprofloxacin for 28 days.

NCT ID: NCT00930904 Completed - Heart Failure Clinical Trials

Model 4196 Left Ventricular (LV) Lead Chronic Performance Study

Start date: June 2009
Phase: N/A
Study type: Observational

The purpose of this study is to evaluate long-term performance of the 4196 LV Lead. This evaluation is based on the number of lead-related complications occurring during the study compared to the number of leads enrolled in the study. The leads will be followed for 5 years after implant. This study is required by FDA as a condition of approval of the Model 4196 LV Lead and is integrated within the Product Surveillance Registry (PAN Registry).