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NCT ID: NCT00920582 Terminated - Clinical trials for Type 1 Diabetes Mellitus

Protege Encore Study- Clinical Trial of Teplizumab (MGA031) in Children and Adults With Recent-Onset Type 1 Diabetes Mellitus

Start date: September 2009
Phase: Phase 3
Study type: Interventional

The primary purpose of this study is to determine whether teplizumab (MGA031) infusions lead to greater reductions in insulin requirements in conjunction with near normal blood sugar control compared to placebo in patients recently diagnosed with type 1 diabetes.

NCT ID: NCT00914628 Terminated - Clinical trials for Acute Leukemia (Category)

Efficacy Study on the Strategy of HSV-Tk Engineering Donor Lymphocytes to Treat Patients With High Risk Acute Leukemia

TK008
Start date: April 12, 2010
Phase: Phase 3
Study type: Interventional

The main objective of this randomized trial is to compare disease-free survival (DFS) in high risk leukemia patients who underwent haploidentical HCT followed by an add back strategy of HSV-Tk donor lymphocytes or standard haploidentical HCT

NCT ID: NCT00912288 Terminated - Alzheimer Disease Clinical Trials

A Phase 3 Efficacy Study Of Dimebon In Patients With Moderate To Severe Alzheimer's Disease

Start date: September 2009
Phase: Phase 3
Study type: Interventional

No Dimebon clinical data exist yet in patients with disease that has advanced to the moderate-to-severe stage. Therefore, this study evaluates the safety and efficacy of Dimebon in patients with moderate-to-severe AD who are receiving existing background therapy with memantine.

NCT ID: NCT00908622 Terminated - Clinical trials for Old Myocardial Infarction

Study of the Efficacy of Percutaneous Implantation of Autologous Myoblasts in Patients With Old Infarction

PERCUTANEO
Start date: March 2007
Phase: Phase 2
Study type: Interventional

The purpose of this study is compare the improvement in global and regional cardiac function measured by echocardiography and magnetic resonance in patients with old myocardial infarction subject to cardiac catheterisation with percutaneous endocavity implantation of autologous myoblasts.

NCT ID: NCT00893867 Terminated - Clinical trials for Acute Ischemic Stroke

Efficacy and Safety Study of DP-b99 in Treating Acute Ischemic Stroke

MACSI
Start date: December 2009
Phase: Phase 3
Study type: Interventional

The purpose of this trial is to determine if intravenous administration of the metal ion trapping agent DP-b99 up to 9 hours following acute ischemic stroke onset, and then for 3 additional days (4 consecutive days in total) is effective in improving long term outcome. Patients will be followed up for 3 months after the stroke.

NCT ID: NCT00893789 Terminated - Clinical trials for Traumatic Brain Injury

Study to Evaluate the Efficacy and Safety of Armodafinil as Treatment for Patients With Excessive Sleepiness Associated With Mild or Moderate Closed Traumatic Brain Injury

Start date: April 30, 2009
Phase: Phase 3
Study type: Interventional

The primary objective of the study is to determine whether armodafinil treatment is more effective than placebo treatment in patients with excessive sleepiness associated with mild or moderate closed traumatic brain injury (TBI).

NCT ID: NCT00886769 Terminated - Clinical trials for Systemic Juvenile Idiopathic Arthritis

Single-dose Study to Assess Efficacy of Canakinumab (ACZ885) in Patients With Active Juvenile Idiopathic Arthritis (SJIA)

ß-SPECIFIC 1
Start date: July 2009
Phase: Phase 3
Study type: Interventional

This study assessed the initial efficacy and safety of canakinumab over a 4 week period in patients with systemic juvenile idiopathic arthritis (SJIA) having a flare. Response to treatment will be according to the adapted American College of Rheumatology(ACR)Pediatric 30 criteria at Day 15.

NCT ID: NCT00885677 Terminated - Heart Failure Clinical Trials

MOnitoring REsynchronization deviCes and cARdiac patiEnts

MORE-CARE
Start date: June 2009
Phase: N/A
Study type: Interventional

The objective of this study is to compare two different strategies of disease management in heart failure patients treated with cardiac resynchronization therapy devices 1. Remote monitoring with CareLink Network System 2. Standard management of the disease by means of scheduled routine in-patient follow-ups; and to demonstrate that the remote monitoring strategy is superior to the standard strategy, both in terms of clinical effectiveness and total healthcare system utilization.

NCT ID: NCT00884390 Terminated - Hemophilia A Clinical Trials

Study Evaluating Safety Of Patients Switching To ReFacto AF In Usual Care Settings

Start date: May 2009
Phase: Phase 4
Study type: Interventional

The study will be investigating safety in patients who switch to ReFacto AF from ReFacto and other Factor VIII products.

NCT ID: NCT00883766 Terminated - Clinical trials for Polycystic Ovary Syndrome

Polycystic Ovary Syndrome (PCOS) and In Vitro Fertilization (IVF): A Comparison Between Standard Long Protocol Versus an Antagonist Protocol Starting on Day 1

Start date: April 2009
Phase: N/A
Study type: Interventional

The aim of this study is to compare two different IVF-stimulation protocols in patients affected by PCOS: the use of a Gonadotropin-releasing hormone (GnRH) - antagonist starting on day 1 of controlled ovarian hyperstimulation (COH) versus a standard long agonist protocol; in order to assess whether it affects the number and quality of Metaphase II (MII) oocytes while reducing the risk of hyperstimulation. Since PCOS patients are also likely to be insulin resistant we also aim to evaluate how metformin affects tha IVF stimulation outcome.