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NCT ID: NCT03725891 Recruiting - Preeclampsia Clinical Trials

Aspirin for Prevention of Preeclampsia in Healthy, Nulliparous Obese and Overweight Pregnant Women

Start date: December 1, 2018
Phase: N/A
Study type: Interventional

Preeclampsia is a pregnancy-specific syndrome that affects 3 - 5% of pregnancies. It is one of the main causes of maternal, fetal and neonatal morbidity and mortality, resulting in approximately 40,000 maternal deaths worldwide each year. Fortunately, preeclampsia-related deaths have been reduced remarkably in recent decades thanks to improvements in antenatal care and therapeutic interventions, and prophylactic use of low-dose aspirin in women who are at a higher risk of developing preeclampsia. Effective prevention is rarely available for obstetric complications. Aspirin is one of them. Several meta-analyses456 suggested that aspirin prescription reduced the risk of preeclampsia and fetal growth restriction by 40-50% in an aspirin-dose-response pattern.

NCT ID: NCT03725579 Recruiting - Clinical trials for Symptomatic Irreversible Pulpitis

Anesthetic Efficacy of 2% Mepivacaine Versus 4% Articaine

Anesthesia
Start date: September 15, 2018
Phase: Phase 2/Phase 3
Study type: Interventional

The aim of this prospective randomized clinical trial was compare between 2% Mepivacaine and 4% Articaine for inferior alveolar nerve blocks in patients with symptomatic irreversible pulpitis in mandibular molars as regards to their anesthetic efficiency; during access cavity preparation and instrumentation.

NCT ID: NCT03725540 Recruiting - Laryngeal Masks Clinical Trials

Oropharyngeal Leak Pressure Monitoring Using Baska Versus I-gel Laryngeal Mask Airway

Start date: November 1, 2018
Phase:
Study type: Observational

The use of supraglottic airway devices with a gastric emptying tube in gynecological laparoscopic surgeries is growing. In addition to their ease of placement, they have low airway morbidity along with sufficient airway pressure in the Trendelenburg position and so they have been determined as an alternative to the endotracheal tube.

NCT ID: NCT03725527 Recruiting - Acute Pain Clinical Trials

Rectus Sheath Block Versus Thoracic Epidural Effect on Diaphragmatic Function After Elective Midline Abdominal Surgery

Rectus
Start date: May 1, 2020
Phase: N/A
Study type: Interventional

This study will be undertaken to compare the respiratory and analgesic effects of thoracic epidural versus ultrasound guided rectus sheath block analgesia after elective abdominal surgery with midline incision.

NCT ID: NCT03725514 Recruiting - Regeneration Clinical Trials

Evaluation of the Survival of Inflamed Mature Single Rooted Teeth

Start date: December 1, 2018
Phase: N/A
Study type: Interventional

The majority of articles present in literature concerning the enrollment of tissue engineering in the field of root canal treatment is concerned with the treatment of affected teeth with immature apex, after proper systematic search online, only 4 articles where found that are dealing with the treatment of teeth with mature apex. These 4 studies are case reports. None of these studies has been a randomized clinical trial, the gold standard of interventional trials resulting in the highest level of evidence that contributes effectively in the clinical decision-making process as to the best intervention for the patient's condition providing the most effective clinical outcomes for the satisfaction of the patient. Since that the triad of regenerative endodontics are the key of success of any attempt to regenerate pulp, 2 different maneuvers shall be done in this study.

NCT ID: NCT03724838 Recruiting - Preeclampsia Clinical Trials

Esomeprazole With Sildenafil Citrate in Women With Early-onset Preeclampsia

Start date: December 1, 2018
Phase: N/A
Study type: Interventional

Previous studies have shown that expectant management of preeclampsia in the context of extreme prematurity may improve perinatal outcomes. Indeed, it has been estimated that for each additional day of pregnancy prolongation between 24 and 32 weeks of gestation, there is a nonlinear corresponding gain of 1% in fetal survival. In this study, we evaluate the use of Esomeprazole alone or with Sildenafil Citrate for the treatment of singleton pregnancies complicated by preeclampsia. We hypothesized that the potential increase in uteroplacental and fetoplacental blood flow with the use of Esomeprazole alone or with Sildenafil Citrate may be associated with pregnancy prolongation (the primary study outcome) and improved maternal and perinatal outcomes.

NCT ID: NCT03724708 Recruiting - Clinical trials for IUD Insertion Complication

Comparing Expulsion Rates for Different Intrauterine Device Insertion Techniques

Start date: December 2, 2018
Phase: N/A
Study type: Interventional

the investigators are trying to determine if this method of intrauterine device (IUD) insertion "hang up technique" has less expulsion rates than 6 week insertion or immediate post-placental insertion.

NCT ID: NCT03723382 Recruiting - Stroke, Acute Clinical Trials

Stroke in Egyptian Clinical REgisTry

SECRET
Start date: May 20, 2018
Phase:
Study type: Observational [Patient Registry]

This is a multi-institutional registry database for the patients with stroke and cerebrovascular diseases. Stroke is the second leading cause of death in the Egypt. Despite extensive research, most of the patients die or suffer from varying degree of post-stroke disabilities due to neurologic deficits. This registry aims to understand the disease and examine the disease dynamics at the National Level. additionally it aim to introduce an objective method for classifying the registered hospital on a spectrum of 6 level coded with colors (from Black to Green ) according the availability of the predetermined 5 bundles of services presented for patient

NCT ID: NCT03723031 Recruiting - Clinical trials for Hemorrhage, Postpartum

Intrauterine Misoprostol Versus Rectal Misoprostol in Reducing Blood Loss During Cesarean Section

Start date: November 15, 2018
Phase: Phase 2
Study type: Interventional

98 pregnant women attending for CS will be randomized into 2 groups. Rectal misopristol group who will receive 400 microgram misoprostol rectally preoperatively with urinary catheter insertion and intrauterine misopristol group will receive 400 microgram misoprostol intrauterine (200 microgram at each cornu) intraoperatively following the delivery of the placenta. The estimated blood loss for each patient will be measured and data of both groups will be compared.

NCT ID: NCT03721627 Recruiting - Gaucher Disease Clinical Trials

Chronic Hepatitis C Treatment in Egyptian Children With Gaucher Disease.

Start date: April 3, 2018
Phase: Phase 4
Study type: Interventional

This prospective open label study is designed to screen all available Gaucher disease patients [either on enzyme replacement therapy (ERT) or not] for hepatitis C virus (HCV) infection. Furthermore to evaluate the safety and effectiveness of combined Sofosbuvir/Ledipasvir regimen given for 12 weeks in chronically infected patients aged 6-18 years.