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NCT ID: NCT04387630 Recruiting - Breast Cancer Clinical Trials

Neoadjuvant Chemotherapy With or Without Metformin in Early Breast Cancer.

Start date: June 5, 2020
Phase: Phase 2/Phase 3
Study type: Interventional

Metformin is a widely used anti-diabetic drug. Several studies have pointed out a potentially beneficial effect of metformin therapy in diabetic cancer patients. Several studies are investigating the anti-tumor effect of metformin in early breast cancer. However, the enhancing effect of metformin on anti-tumor immunity has only been demonstrated in animal models. This study examines the immune effect of metformin in breast cancer patients treated with preoperative chemotherapy.

NCT ID: NCT04386889 Recruiting - Vasculitis Lupus Clinical Trials

SLE Vasculitis In Egyptian Patients

Start date: March 25, 2021
Phase: N/A
Study type: Interventional

Systemic lupus erythematosus (SLE) is a complex heterogeneous autoimmune disease with a wide variety of clinical and serological manifestations that may affect any organ. Vasculitis prevalence in SLE is reported to be between 11% and 36%.

NCT ID: NCT04385342 Recruiting - IVF Clinical Trials

FSH Followed by HMG vs FSH Plus HMG in IVF

Start date: June 30, 2020
Phase: Phase 4
Study type: Interventional

The aim of this study is to compare the clinical outcomes of sequential administration of FSH and HP-hMG FSH alone versus concomitant administration of FSH and HP-hMG during controlled ovarian stimulation in IVF cycles.

NCT ID: NCT04384510 Recruiting - Placenta Accreta Clinical Trials

Placenta Accreta Spectrum Protocol

Start date: March 1, 2020
Phase:
Study type: Observational

Aim of this project is to study diagnosis and management approaches of PAS and to assess safety and efficacy of different conservative approaches compared to planned hysterectomy. We aim at improving selection process and patient counselling for women who would like to consider alternatives to hysterectomy. To achieve these objectives, creation of an international database collected by PAS-experienced centers that represent all continents would promote conduction of large studies that provide higher level of evidence on different options of management of PAS

NCT ID: NCT04382846 Recruiting - COVID Clinical Trials

Novel Regimens in COVID-19 Treatment

Start date: May 8, 2020
Phase: Phase 3
Study type: Interventional

Nitazoxanide has been shown to have a clinical efficacy against severe acute respiratory syndrome coronavirus 2; ivermectin has also demonstrated a remarkable experimental efficacy with a potential to be used for Coronavirus disease 2019.

NCT ID: NCT04379219 Recruiting - Clinical trials for Cesarean Scar Pregnancy

Surgery Alone Versus Methotrexate Before Surgery in Cesarean Scar Pregnancy

Start date: December 1, 2019
Phase: Phase 4
Study type: Interventional

There are no universal treatment guidelines available. The ultimate purpose of the management of CSP is to simultaneously remove the pregnancy and successfully preserve the woman's fertility (Gonzalez & Tulandi, 2017). A variety of medical and surgical treatment modalities for CSP have been reported; however, most of these are based on low‐level evidence(Sun et al., 2019).

NCT ID: NCT04376788 Recruiting - COVID-19 Clinical Trials

Exchange Transfusion Versus Plasma From Convalescent Patients With Methylene Blue in Patients With COVID-19

COVID-19
Start date: May 20, 2020
Phase: Phase 2
Study type: Interventional

The aim of this project is to introduce way for treatment of patients with severe COVID-19 disease with respiratory complications.

NCT ID: NCT04374864 Recruiting - Diabetes Mellitus Clinical Trials

Dose Modification Requirement for Trelagliptin in Egyptian Population

Trelagliptin
Start date: March 1, 2020
Phase: Phase 4
Study type: Interventional

The proposed study will consider the pharmacokinetic evaluation of Trelagliptin after administration to Egyptian volunteers and the results will be compared with the other reported ethnic populations. The FDA recognizes that standard methods of defining racial subgroups are necessary to compare results across pharmacokinetic studies, and to assess potential subgroup differences. The design of the study is open labeled, one treatment, one period, single dose pharmacokinetic study.

NCT ID: NCT04374838 Recruiting - Covid19 Clinical Trials

Effect of COVID-19 Pandemic on Pediatric Cancer Care

Start date: May 15, 2020
Phase:
Study type: Observational

Observational cohort study to assess the effects of COVID19 on pediatric cancer care in Egypt and the Arab World through a survey applied to pediatric oncologists who will be interviewed either directly or through the internet to assess the effect of COVID 19 on pediatric cancer care

NCT ID: NCT04374188 Recruiting - Nephrolithiasis Clinical Trials

Efficacy of Ciprofloxacin Therapy in Avoidance of Sepsis in Patient Undergoing Percutanous Nephrolithotomy

Start date: September 1, 2019
Phase: N/A
Study type: Interventional

Efficacy of ciprofloxacin therapy in avoidance of sepsis in patient undergoing percutanous nephrolithotomy. A randomized controlled trial.