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NCT ID: NCT04411212 Recruiting - Infertility,Female Clinical Trials

G-CSF and PRP in Patients With Recurrent Implantation Failure

Start date: May 28, 2020
Phase: Phase 2
Study type: Interventional

The aim of this randomized controlled trial is to determine whether granulocyte colony-stimulating factor and platelet-rich plasma can be used to enhance the IVF-ET outcomes in patients with recurrent implantation failure

NCT ID: NCT04410588 Recruiting - Clinical trials for Analgesia During Removal of Nasal Pack After Nasal Surgery

Effect of Fentanyl With Topical Levobupivacaine With Nasal Packing in Endoscopic Nasal Surgery

fentanyl
Start date: June 20, 2020
Phase: Phase 2
Study type: Interventional

the Investigators aim to study the effect of fentanyl with topical levobupivacaine with nasal packing in endoscopic nasal surgery

NCT ID: NCT04407065 Recruiting - Infertility, Female Clinical Trials

Double Trigger in Patients With Low Number of Oocytes Retrieved Per Number of Preovulatory Follicles

Start date: May 30, 2020
Phase: Phase 2
Study type: Interventional

The aim of this randomized controlled trial is to determine whether co-administration of GnRH agonist and hCG for final oocyte maturation ( 40 and 34 h prior to oocyte retrieval , respectively) can increase the oocytes yield in patients with history of poor oocytes yield, despite normal response to COH, due to low (<50%) number of oocytes retrieved per number of follicles > 14 mm in diameter on day of hCG administration

NCT ID: NCT04407052 Recruiting - Infertility, Female Clinical Trials

Double Trigger in Patients With Low Proportion of Mature Oocytes

Start date: May 30, 2020
Phase: Phase 2
Study type: Interventional

The aim of this randomized controlled trial is to determine whether co-administration of GnRH agonist and hCG for final oocyte maturation ( 40 and 34 h prior to oocyte retrieval , respectively) can increase the number of mature oocytes in patients with history of low proportion of mature oocytes in previous IVF cycle triggered by HCG.

NCT ID: NCT04406168 Recruiting - Bladder Cancer Clinical Trials

Assessment of Urinary Diversions Outcomes Post Radical Cystectomy in Asyut University Urology Hospital

Start date: June 1, 2020
Phase:
Study type: Observational

Radical cystectomy (RC) for bladder cancer requires reconstruction of the lower urinary tract. Both continent and incontinent diversions are available for urinary reconstruction after RC. Types of urinary diversions include ( ileal conduit, uretero-cutaneous, ureterosigmoidostomy and orthotopic bladder) The decision process is complex and involves consideration of issues related to cancer stage, patient comorbidities, treatment needs, and patient desires related to Quality of life and intraoperative findings. Outcomes of urinary diversions include 1- survival rate (cancer specific or overall survival). 2- Oncological failure (local, distant or LNs). 3- Complications (perioperative, intraoperative or post-operative). In this study, all these outcomes will be analyzed.

NCT ID: NCT04402411 Recruiting - Surgery Clinical Trials

Quadratus Lumborum Block vs Transversus Abdominis Plane Block in Bladder Cancer Surgeries

Start date: June 1, 2020
Phase: N/A
Study type: Interventional

Transversus abdominis plane (TAP) block can be used to provide effective analgesia during the postoperative period following a range of surgeries. TAP block administers local anesthetics between the T6 to L1 spinal nerve roots to stop the nerve signal and to alleviate pain for abdominal procedures 4, 5. The viscera are innervated by the vagal nerve (parasympathetic innervation) and by the splanchnic nerves (sympathetic innervation). The splanchnic nerves carry both visceral efferent and afferent nerve fibers. The sensory (or afferent) part of the splanchnic nerves reach the spinal column at certain spinal segments, It is possible to block central visceral pain conduction with thoracic paravertebral blockade or maybe even with the novel quadratus lumborum (QL) block. The effect of the QL block is believed to result from a spread of LA from its lumbar deposition cranially into the thoracic paravertebral space (TPVS), since Carney et al found traces of contrast agent in the TPVS following application of this block. Hence, the QL block would seem to be able to alleviate both somatic and visceral pain.10 The aim of this study is to compare between quadratus lumborum block, transversus abdominis plane block regarding perioperative analgesia after bladder cancer surgeries by measuring intraoperative hemodynamics, postoperative pain scores and morphine consumption in the first 24 h postoperative.

NCT ID: NCT04402177 Recruiting - Clinical trials for Hypersensitivity Pneumonitis

This Study Aim is to Compare the Effect of Oral Methyl Prednisolone on Different Radiological Patterns of Hypersensitivity Pneumonitis as it Was Found That Not All Patients Get Satisfying Therapeutic Effect After Taking Corticosteroids.

Start date: July 1, 2020
Phase: Phase 4
Study type: Interventional

The Aim of This Work is to Compare the Effect of Oral Methyl Prednisolone on Different Radiological Patterns of Hypersensitivity Pneumonitis and to Evaluate the Patient's Clinical and Functional Status After Taking the Required Dose of Methyl Prednisolone. Not All Hypersensitivity Pneumonitis Patients get the Same Therapeutic Effect after taking Corticosteroid so by Comparing the Effect of Methyl Prednisolone on Patients With Different Radiological Pattern we Will be Able to Select the Patient Who Really Need to Take Corticosteroid and Who Don't so we Will Protect the Patient Who Doesn't Need to Take Oral Corticosteroids From Its Numerous Side Effects All Patients Will Undergo the Following Assessment Before and After Taking 0.5 mg/kg/Day of Methyl Prednisolone for 8 Weeks : High Resolution CT (HRCT) of Chest , Chest X-ray , Spirometry, 6 Minute Walk Test to Evaluate the Patient's Functional Status and Oximetry to Measure Percentage of Oxygen in Blood

NCT ID: NCT04401852 Recruiting - Clinical trials for Fetal Neuroprotection

Magnesium Sulfate for Fetal Neuroprotection

Start date: May 21, 2020
Phase: N/A
Study type: Interventional

Pregnant women diagnosed to have intrapartum fetal distress (Non reassuring or pathological changes according to NICE guidelines 2017) in any of the groups will receive the allocated treatment at least 20 minute before the procedure (emergency CS). measures to reduce the effect of hypoxia will be applied to all participate through: - The position of the mother will be changed to left lateral position (allow increased blood supply). - I.V. fluid bolus (to avoid maternal dehydration). - Oxytocin or cervical ripening agent will be discontinued. - Fetal heart rate monitoring with cardiotocography will be attempted. - If umbilical cord prolapse is noted, elevate the presenting fetal part until preparing for emergency operative delivery. - After birth, Apgar score will be used to identify distress newborns that need resuscitation. The study comprised 200 pregnant women. They were divided into two groups each are 100: - Group A: pregnant women diagnosed to have intrapartum fetal distress who will receive MgSO4. - Group B: pregnant women diagnosed to have intrapartum fetal distress who will receive placebo

NCT ID: NCT04401839 Recruiting - Clinical trials for Post Partum Hemorrhage

Amr Maneuver for Prevention of Postpartum Hemorrhage

Start date: May 31, 2020
Phase: N/A
Study type: Interventional

The patients were divided randomly in to 2 GROUPS: - control group: 153 patients received Oxytocin 10 IU I.V shot administered at the time of delivery of the anterior shoulder of the baby according to the WHO recommendation for both groups in prevention of postpartum haemorrhage,followed by active management of the third stage of labor by administration of oxytocin 5 IU units IM (WHO GDG recommendations,2012) and waiting for signs of placental separation then controlled cord traction (CCT)to the umbilical cord while applying simultaneous counter-pressure to the uterus, through the abdomen(Brandt Andrews maneuver) - study group:156 patients received Oxytocin 10 IU I.V shot at the time of delivery of the of the anterior shoulder of the baby according to the WHO recommendation .Then oxytocin is stopped and cervical traction (Amr maneuver )is applied.

NCT ID: NCT04401098 Recruiting - COVID 19 Clinical Trials

Changing Of Egyptian Population Behaviour Towards COVID 19 Outbreak

Start date: May 2, 2020
Phase:
Study type: Observational

During the COVID-19 pandemic, the Egyptian government issued movement restrictions and placed areas into quarantine to reduce the spread of the disease. In addition, individuals were encouraged to adopt personal protective measures, such as social isolation , increasing personal hygiene and wearing protective face masks. Information regarding the COVID 19 virus and protective measures is found on social media and ministry of health website and a number of the Egyptian population are keeping track of them .Public Awareness play a major rule in reducing the spread of COVID 19 so in this study a survey is done to measure the awareness of the Egyptian population toward COVID 19 , their knowledge and attitude and their adherence to preventive measures.It also measures the change of their behavior during the beginning of the outbreak and after a few months of the outbreak in Egypt.