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NCT ID: NCT05410613 Recruiting - Venous Leg Ulcer Clinical Trials

Combined Electromagnetic Field and a Plantar Resistance Exercise With Venous Leg Ulcer

Start date: January 20, 2022
Phase: N/A
Study type: Interventional

The purpose of this study will investigate the effects of combined electromagnetic field and a plantar resistance exercise therapy versus electromagnetic field on healing of venous leg ulcer .

NCT ID: NCT05410249 Recruiting - Thrombocytopenia Clinical Trials

Assessment of FOXP3 Gene Polymorphisms and Serum Interleukin 10 in Patients With ITP

FoxP3ITP
Start date: June 10, 2022
Phase:
Study type: Observational

Immune thrombocytopenia (ITP) is an autoimmune condition characterized by increased platelet destruction and suppression of production resulting in isolated thrombocytopenia. The exact etiology of ITP is unknown; however, multiple disease mechanisms exist and are mostly related to immune dysregulation [1]. Many studies in recent years have indicated that regulatory T cells (Tregs) play a critical role in the maintenance of immunological tolerance, and they have been reported to be defective in ITP patients, either numerically or functionally. [2-6]. They inhibit the activation and proliferation of effector T cells by the secretion of cytokines such as interleukin-10 (IL-10) and tumor growth factor-β (TGF-β) and by cell-to-cell interaction [7, 8].

NCT ID: NCT05410080 Recruiting - Clinical trials for Gestational Diabetes

the Efficacy of Fetal Arterial and Venous Doppler Indices in Predicting Perinatal Outcome

Start date: June 15, 2022
Phase:
Study type: Observational

To determine and evaluate the diagnostic performance of Doppler sonography of umbilical artery (UA), fetal middle cereberal artery (MCA), ductus venosus (VD) and umbilical vein (UV) for prediction of adverse perinatal outcome among diabetic pregnant women.

NCT ID: NCT05409729 Recruiting - Fertility Disorders Clinical Trials

Subclinical Hypothyrodism and Ovarian Reserve

Start date: January 1, 2016
Phase:
Study type: Observational

This study aimed to evaluate the potential association of subclinical hypothyrodism and ovarian reserve in reproductive age in age groups more than 35 and age groups less than 35 using retrospective study included women with subclinical hypothyrodism and controls .Evaluation of potential association of antithyroid antibodies positivity on ovarian reserve Primary outcome: Measure the association of SCH with ovarian reserve markers (basal FSH ,LH/basal AFC /AMH)

NCT ID: NCT05409365 Recruiting - Healthy Clinical Trials

Assessment of Squamous Cell Carcinoma antigen2 in Verruca Vulgaris

Start date: May 1, 2022
Phase:
Study type: Observational

This study aims to assess the expression of SCCA2 in the skin of patients with warts and to detect its correlation with characteristics of warts.

NCT ID: NCT05408299 Recruiting - Clinical trials for Immune Response to Covid 19 Vaccination

Comparative Study of Patterns of Immune Response to COVID 19 Vaccination

Start date: June 20, 2022
Phase:
Study type: Observational

An effective vaccine stands as the most effective way for controlling the COVID 19 pandemic , yet, immunogenic vaccine efficacy needs to be extensively studied . T cell responses against the structural proteins have been found to be the most immunogenic in peripheral blood mononuclear cells of convalescent SARS-CoV1 patients which needs to be tested in SARS -COV2 vaccine efficacy studies alongside with the sustainability of humoral and cellular immune responses . Clinically , immunocompromised patients face drastic outcome of infections , which led the Advisory Committee on Immunization Practices (ACIP) - USA -and the Joint Committee on Vaccination and Immunisation (JCVI) -UK- recommend COVID-19 vaccination of immunocompromised , the WHO Strategic Advisory Group of Experts on Immunization (SAGE), recommended that the three vaccines(Pfizer ,Moderna and Astra Zeneca) can be used for individuals with high-risk comorbidities . Nevertheless, there is an unmet research need concerning the immune response towards COVID 19 vaccination in this population . Based on the previous work of our team in designing B and T cell epitopes distributed over the S protein , we will study the immune response in the available vaccines in Egypt.

NCT ID: NCT05408208 Recruiting - Localized Psoriasis Clinical Trials

Intralesional Injection Of Methotrexate Versus Triamcinolone Acetonid In Treatment Of Localized Psoriasis

Start date: May 21, 2022
Phase: N/A
Study type: Interventional

The aim of the present study is to evaluate the efficacy of intralesional injection of methotrexate in comparison with Intralesional Injection of Triamcinolone Acetonid in localized psoriasis (body surface area < 10%) .

NCT ID: NCT05407974 Recruiting - Pneumothorax Clinical Trials

Pleurectomy Versus Pleural Abrasion in Patients With Spontaneous Pneumothorax

Start date: October 3, 2021
Phase: N/A
Study type: Interventional

Pneumothorax refers to air in the pleural cavity (i.e. interspersed between the lung and the chest wall).1 Primary spontaneous pneumothorax (PSP) mostly occurs in healthy individuals without an apparent cause, probably due to the rupture of subpleural blebs located mostly on the apex of the lung or the apical segment of the lower lobe. Compared to PSP, a secondary spontaneous pneumothorax (SSP) occurs in the setting of underlying pulmonary disease, like COPD.2 Surgical treatment involves resection of apical bleb disease and pleurodesis which could be chemical or mechanical. Mechanical pleurodesis accomplished either via pleurectomy or pleural abrasion.3 In this study, we aim to compare the efficiency and recurrence risk of pleural abrasion versus pleurectomy in patients with Spontaneous pneumothorax.

NCT ID: NCT05404191 Recruiting - Burn Wound Clinical Trials

Prediction Rules for Low Level Laser on Burn Wounds

Start date: December 1, 2022
Phase: N/A
Study type: Interventional

The purpose of this study is to investigate whether patients' age, total burned surface area, wound stage and wound depth determine wound healing response to low level laser therapy in burn patients

NCT ID: NCT05402800 Recruiting - Sexual Dysfunction Clinical Trials

Sexual Dysfunction in Infertile Women With PCOS Undergoing Fertility Treatment

Start date: January 1, 2022
Phase:
Study type: Observational

Infertility, defined as the inability to become pregnant after one year of regular unprotected sexual intercourse. It is estimated that around 20 % of couples suffer from infertility with prevalence rates of infertility differing substantial among countries . Sexual function in females is very complex and is affected by many factors. The prevalence of sexual dysfunction is higher in infertile patients compared to the normal population . Whether sexual dysfunction is the cause or consequence of subfertility is difficult to establish. For instance, sexual dysfunction might result in decreased coital frequency compounding the issue of subfertility due to reduced exposure. On the other hand, the psychological pressure to get pregnant stemming from sex on demand could result in a reduction in enjoyment of sex aggravating sexual dysfunction. Indeed, situational sexual dysfunction and loss of a couple's intimacy may occur as a consequence of timed intercourse where focus for coitus is no longer pleasure but conception .