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NCT ID: NCT05539911 Recruiting - Pain Clinical Trials

Fentanyl as an Adjuvant to Peribulbar Block in Buckle or Squint Surgeries

Start date: September 1, 2022
Phase: Early Phase 1
Study type: Interventional

The use of fentanyl as an adjuvant to local anesthetic mixture in many regional blocks. It was effective when used in peribulbar block in cataract and vitreoretinal surgeries. Our study will assess its efficacy in abolishing pain during muscle traction which is usually a complain for many patients a reason to use systemic opioid intra operatively or even general anesthesia

NCT ID: NCT05539287 Recruiting - Clinical trials for Drug Resistant Epilepsy

Clinical Study Evaluating the Safety of Lactobacillus Probiotic in Children With Drug Resistant Epilepsy

Start date: September 25, 2022
Phase: Phase 2
Study type: Interventional

Animal and human studies have brought up evidence supporting Gut microbial disbalance, namely dysbiosis, as a causative factor of epilepsy, especially the refractory form. thus, probiotics might constitute a safe, low-cost, and effective supplementary therapy in patients with DRE. The Lactobacillus population is probiotic bacteria that have a beneficial role in epilepsy. Lactobacillus can influence brain function through the modulation of GABA, as shown in rodent models. Moreover, it has been demonstrated in animal models of epilepsy and in human epileptic patients that probiotic treatment aimed at restoring gut microbiota equilibrium has beneficial effects on epileptic symptoms by increasing GABA in animals and the levels of Bifidobacteria and Lactobacillus in humans.

NCT ID: NCT05539027 Recruiting - Clinical trials for Hepatic Encephalopathy

Efficacy of L-Ornithine L-Aspartate (LOLA) as an Adjunct to Branched Chain Amino Acids (BCAA) Enriched Solutions on Clinical Outcomes in ICU Patients With Hepatic Encephalopathy

Start date: September 20, 2022
Phase: Phase 4
Study type: Interventional

One of the most significant goals of hepatic encephalopathy (HE) treatment is to reduce ammonia levels by lowering its synthesis and enhancing its detoxification which can be achieved by using non-absorbable disaccharides, antibiotics, branched-chain amino acids (BCAA), L-ornithine L-aspartate (LOLA), and probiotics. LOLA decreases ammonia, therefore, it is presumed to decrease agitated delirium in HE patients and thus decrease their need for other sedatives. On the other hand, BCAA improve mental function in HE patients by increasing the detoxification of ammonia in muscles.

NCT ID: NCT05538780 Recruiting - Clinical trials for Transient Tachypnea of the Newborn

Diagnosis of Transient Tachypnea of Newborn

Start date: January 1, 2022
Phase:
Study type: Observational

Transient tachypnea of the newborn (TTN) is the most common cause of respiratory distress in fullterm newborn. TTN is a diagnosis of exclusion, It is primarily diagnosed based on medical history and typical clinical presentation. Lung ultrasonography is an accurate, non invasive and reliable tool for diagnosing TTN. Cardiometry is presently the only tool to evaluate thoracic fluid content continuously and noninvasively at the bedside.

NCT ID: NCT05538559 Recruiting - Dental Caries Clinical Trials

Carie Care, Chemomechanical Caries Removal Technique in Primary Teeth

Start date: June 1, 2022
Phase: N/A
Study type: Interventional

Chemomechanical caries removal systems have emerged as a possible valuable alternative to conventional rotary caries removal techniques in pediatric patients. Carie-Careā„¢ is an economically minimally invasive approach that selectively removes caries-infected tissue leaving the caries-affected tissue to conserve tooth structure

NCT ID: NCT05538260 Recruiting - Clinical trials for Pediatric Ocular Trauma

Pediatric Ocular Trauma in Minia Governate

Start date: May 15, 2017
Phase: N/A
Study type: Interventional

The most common cause of unilateral blindness in pediatric age groups, especially in developing countries, is ocular trauma. The epidemiology of eye injuries varies in different parts of the world and different age groups and depends on many factors including life style, socioeconomic status, traffic state, sport and creative activities and type of registration and recording of data. About half a million people in the world are blind as a result of eye injuries. About 30-40% of monocular blindness is due to ocular trauma

NCT ID: NCT05538078 Recruiting - Clinical trials for Periodontal Diseases

Ozone Gel Application in Controlled Type 2 Diabetic Patients With Periodontitis

Start date: October 15, 2022
Phase: N/A
Study type: Interventional

The adjunctive topical subgingival application ozone gel creates a great improvements in the clinical, bacteriological and immunological parameters over the gold standard of periodontal pocket treatment alone.

NCT ID: NCT05537207 Recruiting - Pelvic Pain Clinical Trials

Laser at Lumbar Acupoint on Pain and Quality of Life in Chronic Pelvic Pain

Start date: July 1, 2022
Phase: N/A
Study type: Interventional

To investigate the effect of low-level laser at lumbar sensitized acupoint on pain perception in chronic pelvic pain. BACKGROUND: chronic pelvic pain is one of the serious problems in the female, resulting in pain and less physical activity.

NCT ID: NCT05536856 Recruiting - Vitiligo Clinical Trials

Topical 5-Fluorouracil Effervescent Powder in the Treatment of Vitiligo

Start date: October 15, 2022
Phase: Phase 4
Study type: Interventional

A novel approach for 5-Fluorouracil delivery based on a solid effervescent formulation is proposed . 5-Fluorouracil is water soluble (~50mg/ml) and therefore has been used for the development of novel topical formulations including nano and microparticles intended for skin targeting. After hydration 5-Fluorouracil could form a complex, a suspension or even be formulated to generate effervescence. In effervescent technology, gas bubbles occur from the liquid after chemical reaction between alkali salts and organic acids (mainly citric or tartaric. Due to liberation in CO2 gas, the dissolution of drug in water is enhanced. The aim of this study is the development and clinical evaluation of topical 5-florouracil effervescent powder formulation in the treatment of vitiligo.

NCT ID: NCT05534334 Recruiting - Clinical trials for Oral Pyogenic Granuloma

Corticosteroid Intralesional Injection as an Alternative Treatment in Oral Pyogenic Granuloma in the Esthetic Zone.

Start date: May 1, 2022
Phase: Phase 2/Phase 3
Study type: Interventional

Gingival Pyogenic granuloma in the esthetic zone represents an esthetic problem. While surgical treatment may not give the premium esthetic demands, corticosteroid may acheive this balance.