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NCT ID: NCT05763303 Recruiting - Clinical trials for Diabetes Self Management

Impact of an Interventional Program on Self-Management

Start date: October 25, 2023
Phase: N/A
Study type: Interventional

The goal of this randomized clinical trial study is to assess the effect of an interventional program on diabetes self-management and therefore on effective glycemic control among diabetic students in Assuit university

NCT ID: NCT05761002 Recruiting - Clinical trials for Human Papilloma Virus

Human Papilloma Virus Genotypes and Treatment Outcomes of Intralesional Immunotherapy of Anogenital Warts

Start date: June 1, 2022
Phase: N/A
Study type: Interventional

This study aims to investigate the relationship between HPV genotypes and treatment outcomes of intralesional immunotherapy of anogenital warts with the quadrivalent vaccine (Gardasil).

NCT ID: NCT05759702 Recruiting - Clinical trials for Body Mass Index,Manual Dexterity,Handgrip Strength,School Aged Children

Correlation Between Body Mass Index, Manual Dexterity and Handgrip Strength in School Aged Children

Start date: January 1, 2023
Phase:
Study type: Observational

The purpose of current study is to investigate the relation between body mass index, manual dexterity and handgrip strength in school aged children having normal weight, overweight and obesity.

NCT ID: NCT05759533 Recruiting - Anesthesia Clinical Trials

Evaluation of the Corrected Carotid Flow Time and the Inferior Vena Cava Collapsibility Index in Predicting Post-spinal Anesthesia Hypotension in Geriatric Patients

Start date: December 1, 2022
Phase:
Study type: Observational

We include patient who will undergo elective surgeries such as orthopedic surgeries as fixator placement, lower extremity debridement, inguinal hernia, Urosurgery as bladder- prostate resection, hysterectomy, fibroid removal, ovarian cyct removal, plastic surgeries, and other types of surgery. The fasting durations of the included patients will be 8 hours for solids and 2 hours for clear liquids. There won't be any premedication given. The patient will be placed in a supine, neutral-head resting posture in the operating room as well as standard monitors such as a five-lead electrocardiography, pulse oximeter, and noninvasive blood pressure. An attending anesthesiologist will use a 25-gauge Quincke spinal needle to induce spinal anesthesia in the L3/4 or L4/5 vertebral interspace with the patient in the right lateral decubitus posture. Throughout the course of the trial, the attending anesthesiologist will choose the dosages of 0.5% hyperbaric bupivacaine (10 to 15 mg) and fentanyl (10 to 20 mg) 28. The patient will be placed back in the supine position without any lateral tilt once the spinal injection has been given over a period of 15 to 30 seconds. Three minutes following the spinal injection, the sensory block will be evaluated with a cold and pinprick test. The mean blood pressure will be taken every 3 minutes between the spinal injection and delivery, and every 5 minutes from the delivery until the end of the procedure. The lowest SBP measured between the spinal anesthesia injection and delivery will be determined, together with the percentage of the SBP drop from the pre-anesthetic SBP. The patient's head will be turned 308 degrees to the left. First, a 6.0 to 13.0MHz linear array transducer will be positioned vertically on the neck with the probe marker facing the patient's head. The lower edge of the thyroid cartilage will provide a long-axis B-mode picture of the right common carotid artery. The probe will then be positioned in the lumen's center, around 2 cm from where the carotid arteries split. After that, carotid artery blood flow waveforms will be preserved together with a pulsed Wave-Doppler trace of the artery's flow. The cycle time will be determined by counting the number of heartbeats at the start of the systolic upstroke using an ultrasound machine's caliper function. By taking measurements in one-tenth of millisecond intervals between the systolic upstroke and the diastolic notch, the flow time will be determined. the IVC will be scanned using a portable ultrasound device (LOGIQ-e by GE health care) and a 3.5-5 MHz curvilinear probe in the subxiphoid region (paramedian long-axis view), just close to the common hepatic vein's draining to the IVC. At the point where the IVC joins the right atrium, a 2D picture will be obtained. M-mode imaging will be used to record changes in IVC diameter during inspiration and expiration. The procedure is carried out two to three centimeters away from the right atrium/IVC junction. The attending anesthetist will keep track of how long it took to locate the IVC after placing the probe on the patient. The M mode of the ultrasonography will be used to measure the IVC's Minimum (IVCDMin) and Maximum (IVCDMax) diameters, and the IVC Collapsibility Index (IVCCI) will be calculated.

NCT ID: NCT05759403 Recruiting - Parkinson Disease Clinical Trials

Comparison Between Parkinson's Disease and Parkinson's Dementia Complex (Genetically,Clinical and Electrophysiological)

Start date: November 1, 2022
Phase:
Study type: Observational

To compare between Idiopathic PD versus Parkinson-Dementia complex using different modalities: Demographic, Clinical, genetic, Psychometric and electrophysiologically

NCT ID: NCT05759390 Recruiting - Lung Diseases Clinical Trials

Role of Ultrasound Elastography in Differentiation of Peripheral Lung Lesions

Start date: June 1, 2022
Phase:
Study type: Observational

Advancements in imaging capacities and the development of a precise puncture-guiding transducer have made transthoracic ultrasonography a useful diagnostic tool for evaluating peripheral subpleural lung tumours. Different human tissues have varying levels of elasticity because of the properties of the extracellular matrix. Pleural two-dimensional (2D) shear-wave elastography (SWE) can be used to differentiate between malignant pleural effusion and benign pleural disease. Transthoracic 2D-SWE uses acoustic radiation force and assesses the velocity of tissue displacement propagation in multiple focal zones. The shear waves are monitored in 2D by creating a near-cylindrical shear-wave cone, enabling measurement of the shear-wave speed or Young's modulus (E) on a colour quantitative elastogram. Based on the hypothesis that transthoracic 2D-SWE could add accurate tissue stiffness information to B-mode grayscale ultrasound images and help in differentiating lung malignancy from benign lung lesions.

NCT ID: NCT05758207 Recruiting - Clinical trials for Hematologic Malignancy

Oral Complications in Hematological Malignancies

Start date: May 15, 2023
Phase:
Study type: Observational

The aim of this study was to evaluate the prevalence and types of oral complications found in patients diagnosed with haematological malignancy

NCT ID: NCT05758064 Recruiting - Clinical trials for Hormonal Replacement Frozen Embryo Transfer Cycle

The Rescue of Hormonal Replacement Frozen Embryo Transfer Cycle With Low Serum Progesterone.

Start date: January 1, 2023
Phase: Phase 2/Phase 3
Study type: Interventional

Frozen embryo transfer (FET) is increasingly adopted strategy in modern IVF. Among the many factors that have contributed to such change, the pursuit of an ovarian hyperstimulation syndrome free clinic has been strongly required. Improvements in the vitrification and warming processes and the excellent cryo-survival rates have turned FET in our main tool for preventing this complication. Moreover, a freeze all strategy has proven to provide excellent or even better pregnancy rates (PRs), not only in high but also in normal responders. While ART have rapidly evolved in the areas of embryo culture, vitrification and understanding of the embryo development, little progress has been achieved regarding endometrial preparation for FET. Undoubtedly, correct implantation requires a good quality embryo and a suitable decidualized endometrium. Artificial cycles require hormone replacement treatment (HRT) with estradiol and progesterone (P4). However, there is not a single standardized treatment described for optimal endometrial preparation and no protocol has proven superiority in terms of reproductive outcomes.(5, 6) Although artificial preparation is the most convenient method to schedule FET cycles, recent reports have highlighted a potentially detrimental effect of low P4 levels prior to FET on miscarriage and live birth rates (LBRs). These results have been observed both in homologous and oocyte recipient FET cycles(7, 8), but also in FET cycles of embryos that had undergone PGT for aneuploidies (PGT-A).(9) Additional P4 supplementation may be a way to improve reproductive outcomes in these patients. Our open labelled randomized control study aims to investigate whether patients with low serum P4 levels the day before FET under standard HRT can benefit in terms of clinical and ongoing pregnancy and implantation rates from an individualized luteal phase support consisting in the addition of oral dydrogesterone supplementation or daily subcutaneous P4 injection.

NCT ID: NCT05757999 Recruiting - Muscle Relaxation Clinical Trials

Effect of MgSO4 Pretreatment on Muscle Relaxation

MgSO4/CisA
Start date: July 23, 2023
Phase: Phase 2/Phase 3
Study type: Interventional

In this study, the effect of magnesium sulphate on the onset and duration of intense and moderate cis-atracurium induced neuromuscular blocking and on the period of no response to nerve stimulation will be evaluated in patients who will recieve magnesium sulphate (intervention group) and patients who will not recieve magnesium sulphate (comparator group).

NCT ID: NCT05757037 Recruiting - Clinical trials for Constipation-predominant Irritable Bowel Syndrome

Laser Acupuncture on Irritable Bowel Syndrome in Females

Start date: March 1, 2023
Phase: N/A
Study type: Interventional

The aim of the study to investigate effect of laser acupuncture on constipation predominant irritable bowel syndrome in female patients