There are about 11304 clinical studies being (or have been) conducted in Denmark. The country of the clinical trial is determined by the location of where the clinical research is being studied. Most studies are often held in multiple locations & countries.
An abnormal intestinal microbiota may be the mediator of the common inflammatory pathways seen in psoriatic arthritis. This study will explore clinical aspects associated with modifying the intestinal microbiota by infusing fecal donor microbiota into the small intestine of psoriatic arthritis patients with a minimum of three swollen joints despite at least three months of methotrexate treatment.
The main purpose of the study is to investigate the importance of patients' beliefs regarding staying active despite low back pain, among patients referred from general practice to secondary care treatment in Denmark. It is hypothesised that patients believing that staying active will help them recover will have higher odds of a 30%-improvement in The Roland Morris Disability score after 52 weeks compared to patients disagreeing that staying active will lead to better recovery.
The aim of this study is to assess prospectively the critical period prior to the development of Acute-on-Chronic Liver Failure (ACLF) (1), to uncover mechanistic and pathophysiological processes associated with the development and clinical course of ACLF (2) and to identify the precipitating events of ACLF (3).
Expand the indication of the Portico TF Delivery System and obtain approval of the Alternative Access Delivery System
Degenerative shoulder disorders are frequent in the Danish population and often cause disability and sick leave. After hospital discharge patients are often referred to physiotherapy rehabilitation as part of the treatment, and it is often assumed that one-on-one sessions will yield better results than group-based sessions, because individual needs can be better meet and targeted The project aims to evaluate the effect and cost-effectiveness of group- based exercise rehabilitation as compared to individual exercise rehabilitation in patients with degenerative shoulder disorders.
Patellofemoral pain (PFP) is highly prevalent in both adolescent and adult populations and as much as 91% of those affected experience ongoing knee pain for up to 20 years after the initial diagnosis. Exercise-based treatment focusing on strengthening the muscles around the hip and knee is usually effective when treating patient with PFP. However, this approach has proven ineffective in a subgroup of females who have suffered from PFP for multiple years. This group was found to have a significantly lower tolerance for pressure stimuli compared to healthy controls. This indicating that central mechanisms within the nervous system rather than the problem being the knee itself. Exercising a non-painful muscle distant to a painful part of the body has previously been effective in deceasing pain in affected area. This mechanism has been investigated in patients with long-standing musculoskeletal pain as well as healthy populations. Related research has suggested that a possible link between patients perception of painful stimuli an the pain-reducing effect of exercise exists. As such, patients witch experienced a pain reducing effect of exercise was found to be able to tolerate more pain than before the intervention. The aim of this study is to assess if exercising a distant non-painful muscle around the hip has a larger acute pain-reducing effect on knee pain compared to knee specific exercises in female patients with long-standing PFP.
The study includes healthy young habitually active subjects. All subjects are subjected to two weeks of immobilization of one leg followed by four weeks of training of both legs. The subjects are randomized to either one-leg training of the non-immobilized leg during the two-week immobilization period or to no training of the non-immobilized leg during the immobilization period. Measures include skeletal muscle morphology, markers of angiogenesis and apoptosis, muscle metabolic markers, vascular function, vascular proteins and performance.
This study aims to investigate the effect of an intervention consisting of early, individualised outpatient follow-up after heart valve surgery on unplanned readmissions and death within 180-days after discharge. Furthermore, Health economics and health-related quality of life will be investigated.
The purpose of the study is to evaluate the clinical efficacy of UCB7665 as a chronic-intermittent treatment in subjects with generalized myasthenia gravis (MG) who are classified as moderate to severe.
The aim of the project is to investigate the effects in humans of a daily intake of whole milk compared to skimmed milk primarily and secondarily respectively on: - Blood lipids: total-, LDL-, and HDL-cholesterol and triglycerides - Risk markers of diabetes type 2: plasma glucose and insulin