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NCT ID: NCT04921384 Recruiting - Migraine Clinical Trials

Eptinezumab as Preventive Treatment of Migraine in Adults With Migraine

Sunrise
Start date: May 29, 2021
Phase: Phase 3
Study type: Interventional

This study evaluates the efficacy of eptinezumab to prevent migraine in participants with chronic migraine.

NCT ID: NCT04921111 Recruiting - Clinical trials for HPV Infection Vaccine Safety SCT1000

A Phase I Safty and Immunogenicity Study of SCT1000 in Healthy Women Aged 18 to 45 Years

Start date: July 2, 2021
Phase: Phase 1
Study type: Interventional

A phase 1 random, double blind, positive and placebo control trail was conducted in 120 healthy women in the arm A: 18-26 years old and Arm B: 27-45 years old. The 40 subjects to be inoculated with low, middle, and high dose vaccinefirst in sequence if there was no safety issue. In each dose group SCT1000 : placebo: positive =3:1:1.Two arms can be recruited at the same time. If the DSMB assessment shows that the adverse events of a certain dose group meet the criteria of suspension / termination, the dose group will be suspended / terminated, and the vaccination of this dose group or higher dose group will not be carried out, and the study of other dose groups will continue. If this happens at a low dose, the study will be suspended / terminated.

NCT ID: NCT04921020 Recruiting - Eyelid Diseases Clinical Trials

Assessment of Eyelid Topology and Kinetics Based on Deep Learning Method

Start date: August 1, 2020
Phase:
Study type: Observational

This study plans to assess eyelid topology (such as margin reflex distance, eyelid contour, and corneal exposure area) and blinking (such as frequency, velocity, and duration), using deep learning method to automatically extract eyelid topological features, and to predict subtypes of levator function, using deep learning method to extract blinking features, in order to provide new ideas and means to assess eyelid topology and kinetics.

NCT ID: NCT04920500 Recruiting - Clinical trials for Acute Myeloid Leukemia

Bioequivalence of Daunorubicin Cytarabine Liposomes in Naive AML Patients

Start date: September 4, 2020
Phase: N/A
Study type: Interventional

A Randomized, Double-blind, Multiple-Dose, Two-Cycle, Parallel-Group, Bioequivalence pretrial of Daunorubicin Cytarabine liposome for Injection in older, naive patients with Acute Myeloid Leukemia (AML).

NCT ID: NCT04920240 Recruiting - Hospital Infection Clinical Trials

Application of Standardized Cleaning and Disinfection Mode of HFT Surface in Hospital Infection Prevention and Control

Start date: January 1, 2020
Phase: N/A
Study type: Interventional

The scientific, feasible and effective mode of standardized cleaning and disinfection of ICU high-frequency contact surfaces is discussed and verified.

NCT ID: NCT04920227 Recruiting - Clinical trials for Glaucoma, Open-Angle

Comparation of CLASS Combined With Phacoemulsification and CLASS Alone in the Treatment of Primary Open Angle Glaucoma

Start date: September 2, 2020
Phase: N/A
Study type: Interventional

To compare the effect of intraocular pressure control and the incidence of peripheral anterior synechia between CLASS combined with phacoemulsification and CLASS alone in the treatment of primary open-angle glaucoma

NCT ID: NCT04920214 Recruiting - Clinical trials for Hepatocellular Carcinoma

Application Value of CEUS Li-RADS in Hepatic Focal Lesions in Patients With Non-high Risk Factors for HCC

Start date: January 1, 2021
Phase:
Study type: Observational

Currently, there are few studies on the diagnostic ability of CEUS-LI-RADS in patients with non-high risk factors for liver nodules. Whether this classification is applicable to such patients remains controversial. There are relatively few studies on the diagnostic efficacy of HCC in clinical diagnosis and the consistency between map readers, and the applicable population is only focused on patients with hepatic fibrosis. Therefore, this study explored the application value of CEUS Li-RADS in liver focal lesions in patients with non-high risk factors for hepatocellular carcinoma.

NCT ID: NCT04919837 Recruiting - Clinical trials for Artificial Intelligence

The Efficacy of an Artificial Intelligence Platform to Adapt Visual Aids for Patients With Low Vision: a Randomised Controlled Trial

AI
Start date: July 27, 2020
Phase: N/A
Study type: Interventional

According to the WHO's definition of visual impairment, as of 2018, there were approximately 1.3 billion people with visual impairment in the world, and only 10% of countries can provide assisting services for the rehabilitation of visual impairment. Although China is one of the countries that can provide rehabilitation services for patients with visual impairment, due to restrictions on the number of professionals in various regions, uneven diagnosis and treatment, and regional differences in economic conditions, not all visually impaired patients can get the rehabilitation of assisting device fitting. Traditional statistical methods were not enough to solve the problem of intelligent fitting of assisting devices. At present, there are almost no intelligent fitting models of assisting devices in the world. Therefore, in order to allow more low-vision patients to receive accurate and rapid rehabilitation services, we conducted a cross-sectional study on the assisting devices fitting for low-vision patients in Fujian Province, China in the past five years, and at the same time constructed a machine learning model to intelligently predict the adaptation result of the basic assisting devices for low vision patients.

NCT ID: NCT04919811 Recruiting - Clinical trials for Non Small Cell Lung Cancer

Taletrectinib Phase 2 Global Study in ROS1 Positive NSCLC

TRUST-II
Start date: September 1, 2021
Phase: Phase 2
Study type: Interventional

The main purpose of the study is to evaluate safety and efficacy of taletrectinib (also known as AB-106 or DS-6051b) monotherapy in the treatment of advanced NSCLC.

NCT ID: NCT04919603 Recruiting - Physical Activity Clinical Trials

Impact of Exercise Intervention on the Phenome

Start date: June 15, 2021
Phase: N/A
Study type: Interventional

It is an open-label, parallel-group, randomized controlled clinical trial, which is designed to enroll people with different glucose metabolism status who are also overweight or obese, including people with normal glucose metabolism, pre-diabetes patients and newly diagnosed type 2 diabetes patients. The patients are randomized to an enhanced physical activity intervention (high-intensity interval training exercise prescription combined with resistance training) or standard education group (diabetes health education only, including lifestyle education and guidance) for 12 weeks. This trial intends to compare the influence of enhanced physical activity treatment with that of a standard education on liver steatosis, serum glucose and lipids level, insulin sensitivity, cardiovascular metabolic parameters, metabolic molecules, and gut microbiota profile et al.