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NCT ID: NCT04951947 Recruiting - Clinical trials for Small-cell Lung Cancer

JS-201 Combined With Lenvatinib in the Treatment of Small-cell Lung Cancer

Start date: June 1, 2023
Phase: Phase 2
Study type: Interventional

This is a prospective, single-arm phase II clinical study to evaluate the efficacy and safety of JS-201 combined with lenvatinib in the treatment of small-cell lung cancer that has failed previous chemotherapy combined with PD-L1. The primary observational endpoint is ORR, and the secondary observational endpoint is PFS, OS. The intervention mode is JS201 300mg i.v Q2w, lenvatinib 8mg po. Qd.

NCT ID: NCT04951882 Recruiting - Acute Lung Injury Clinical Trials

Application of hUC-MSCs in Treating Acute Lung Injury: a Single Center Prospective Clinical Research

Start date: June 9, 2021
Phase: Early Phase 1
Study type: Interventional

The patients suffered from acute lung ininjury (200<PaO2/FiO2 ≤ 300) will be divided into two groups: MSCs-treated group: patients are treated by intravenous injection of hUC-MSCs suspention ; control group: patients were treated with vehicle(Albumin) . The standard Therapies of acute lung injury were the same in both groups. In the following-up days, all the patients were monitored by the same items to evaluate the therapeutic effects.

NCT ID: NCT04951765 Recruiting - Healthy Clinical Trials

Effect of Food on the Pharmacokinetics of XZP-3287 in Healthy Subjects

Start date: August 2021
Phase: Phase 1
Study type: Interventional

This study will be a randomized 3-treatment, cross-over study to evaluate the bioavailability of XZP-3287 administered after a high or low-fat meal.

NCT ID: NCT04951713 Recruiting - Healthy Clinical Trials

Effect of Clarithromycin and Rifampicin on the Pharmacokinetics of XZP-3287 in Healthy Subjects

Start date: July 2021
Phase: Phase 1
Study type: Interventional

This is a phase I study to assess the drug-drug interaction of XZP-3287 and Clarithromycin/Rifampicin. The study also evaluates the pharmacokinetic and tolerability of XZP-3287 in healthy subjects.

NCT ID: NCT04951635 Recruiting - Clinical trials for Non-small Cell Lung Cancer

A Phase III Study to Assess the Effects of Almonertinib Following Chemoradiation in Patients With Stage III Unresectable Non-small Cell Lung Cancer

Start date: March 18, 2021
Phase: Phase 3
Study type: Interventional

To assess the efficacy and safety of Almonertinib versus placebo following chemoradiation in patients with stage III unresectable epidermal growth factor receptor mutation-positive (EGFRm+) non-small cell lung cancer (NSCLC).

NCT ID: NCT04951622 Recruiting - Myasthenia Gravis Clinical Trials

A Study of Nipocalimab Administered to Adults With Generalized Myasthenia Gravis

Start date: July 15, 2021
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the efficacy and safety of nipocalimab compared to placebo in participants with generalized myasthenia gravis (gMG).

NCT ID: NCT04951596 Recruiting - Emergency Patients Clinical Trials

Management Standard of Bone Marrow Infusion in Acute and Critical Patients

Start date: July 1, 2020
Phase:
Study type: Observational

As the spike in the number and severity of patients with critical patients, then quickly effective transfusion treatment demand becomes more and more serious, and the pattern of infusion pathways have traditionally used already can not adapt to this change, therefore, an urgent need to establish a set of is in line with international standards and accord with the situation of our country is simple, effective and scientific accuracy of IO management solution. In order to ensure the safety of the treatment of acute and critical patients, and in the province and even domestic experts recognized and promoted the application.

NCT ID: NCT04951414 Recruiting - Knee Osteoarthritis Clinical Trials

Study on the Rehabilitation Treatment of Knee Osteoarthritis Based on ICF

Start date: July 1, 2021
Phase:
Study type: Observational

To solve the existing Knee osteoarthritis;KOA) clinical norms and guidelines have low operability, Disconnection between treatment plan and specific evaluation results, difficulty in achieving individualized intervention and other problems, on the one hand, we need to develop Chinese expert consensus or clinical path based on evidence-based medicine to adapt to China's national conditions, on the other hand, is more important in The KOA clinical process introduces a set of tools to translate evidence-based medicine evidence into specific, actionable treatments, Thus, a more flexible, more comprehensive and three-dimensional, adaptable, targeted, more conducive to the promotion of the individual integration KOA rehabilitation intervention program.

NCT ID: NCT04951180 Recruiting - Clinical trials for Femoral Acetabular Impingement

Arthroscopic Treatment for Femoral Acetabular Impingement Syndrome With Gluteus Medius Lesions.

Start date: May 1, 2021
Phase:
Study type: Observational

To evaluate the prognosis of femoral acetabular impingement syndrome (FAIS) patients with gluteus medius lesions after hip arthroscopy.

NCT ID: NCT04951141 Recruiting - Clinical trials for Hepatocellular Carcinoma , Cholangiocarcinoma

Clinical Study of Intratumoral Injection of CAR-T Cells in the Treatment of Advanced Liver Tumors

Start date: January 1, 2019
Phase: Early Phase 1
Study type: Interventional

Objective to study the safety and preliminary efficacy of intratumoral injection of CAR-T cells in the treatment of advanced liver tumors.