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NCT ID: NCT04952272 Recruiting - Lung Cancer Clinical Trials

Intratumor CpG-ODN Injection Boosters Immune Killing Against in Situ Tumor Antigen Release for Advanced Solid Tumors

Start date: March 1, 2021
Phase: Phase 1
Study type: Interventional

To study the safety and clinical effects of intratumor injecting CpG-ODN and in situ release of tumor antigen by interventional ablation or drug-eluting beads to treat advanced solid tumors.

NCT ID: NCT04952246 Recruiting - Multiple Sclerosis Clinical Trials

Clinical Isolation Syndrome of Spinal Cord and Multiple Sclerosis

Start date: January 1, 2010
Phase:
Study type: Observational

The purpose of this study was to investigate the factors that influence the progression of patients with clinically isolated spinal cord syndrome to multiple sclerosis.

NCT ID: NCT04952233 Recruiting - Clinical trials for Artificial Intelligence

Application Value of Deep Learning in Diagnosis of Cervical Spondylosis

Start date: January 30, 2021
Phase:
Study type: Observational

Compared with the personal experience judgment of physicians, deep learning can identify something more quickly, efficiently, and accurately The identification and diagnosis of diseases save the energy of clinical and imaging doctors and achieve an individualized diagnosis of patients Diagnosis and evaluation are beneficial to the formulation of clinical surgical methods and the improvement of patients' prognoses. This study uses deep learning technology, through the big data of cervical spondylosis cases learn, to explore the use of deep learning The feasibility of identifying and analyzing the characteristic imaging findings of cervical CT images that may be suggestive of a diagnosis It is attempted to reach the level of artificial intelligence-assisted diagnosis of cervical spondylosis.

NCT ID: NCT04952207 Recruiting - Clinical trials for Hepatitis C, Chronic

Effectiveness and Safety of Direct-Acting Antiviral Agents for the Treatment of Chronic Hepatitis C

C-DIAMOND
Start date: March 6, 2019
Phase:
Study type: Observational [Patient Registry]

Clinical trials evaluating DAA have shown excellent rates of SVR and good safety profiles in patients with CHC infection. Real world data from TARGET, TRIO, IFI, DHCR, DALTON-C, as well as those cohorts from Japan, Taiwan and Korea further confirmed clinical trial findings of DAA in routine practice where populations are more complex. However, these populations are different from Chinese for different host and virus characteristics which limit the applicability of results to local practice. As DAA launched in China since 2017, the availability of INF free DAA treatment will likely lead to better treatment outcome in routine practice, but there are currently no data available to test the hypothesis. In clinical practice, the uptake of DAA regimen will depend on a combination of physician preference, patient's characteristics and drug access. This study will also identify how these three variables affect DAA regimen uptake. This study to 1) characterize pts receiving IFN free DAA regimens, 2) represent common practice in China, 3) describe outcome of various INF free DAA therapy, and 4) confirm registration study results.

NCT ID: NCT04952194 Recruiting - Parkinson Disease Clinical Trials

Clinical Study of Stalevo in the Treatment of Early Parkinson's Disease

Start date: January 1, 2022
Phase: Phase 4
Study type: Interventional

The main goal of PD research is to develop disease-modifying drugs to delay or prevent the underlying neurodegenerative process. Levodopa, as the gold standard for PD treatment, is associated with the occurrence of motor complications. Many previous studies have confirmed that Stalevo can reduce the side effects of levodopa alone. Moreover, the effects of Stalevo on the treatment of PD patients have been extensively studied, but the efficacy of Stalevo in early PD patients has been less studied. Therefore, it is necessary to further study the treatment of early PD with Stalevo, and observe whether increasing the number of medication can reduce the occurrence of dyskinesis. The research results will help to deepen the understanding of Stalevo in the treatment of early PD and its clinical efficacy.

NCT ID: NCT04952168 Recruiting - NSCLC, Stage III Clinical Trials

Combination of Almonertinib and Concurrent Chemoradiotherapy in Unresectable Stage III NSCLC

Start date: June 2, 2021
Phase: Phase 2
Study type: Interventional

This is a Prospective, open, single arm study to evaluate the efficacy and safety of the almonertinib combined with concurrent chemoradiotherapy in unresectable stage III NSCLC with EGFR mutation

NCT ID: NCT04952155 Recruiting - Clinical trials for Amyotrophic Lateral Sclerosis

Low Dose IL-2 in the Treatment of Immune-associated ALS Syndrome

Start date: January 1, 2020
Phase: Phase 2
Study type: Interventional

The purpose of this study was to evaluate the efficacy and safety of low-dose IL-2 in the treatment of immunorelated ALS syndrome.

NCT ID: NCT04952103 Recruiting - Clinical trials for Cancer of Unknown Primary Site

Real World Study of Diagnosis and First-line Treatment Among Patients With Cancer of Unknown Primary in China

Start date: June 18, 2021
Phase:
Study type: Observational

This study is a prospective, real world study.The objective is to observe the diagnosis and first-line treatment of Chinese patients with cancer of unknown primary, and collect the clinicopathological characteristics, treatment outcomes, survival and other data of the patients.

NCT ID: NCT04952038 Recruiting - Clinical trials for Amyotrophic Lateral Sclerosis

Sleep Disorders and the Onset and Progression of ALS

Start date: August 1, 2020
Phase:
Study type: Observational

200 cases of ALS patients were collected to explore whether sleep disorders are related to earlier onset age, and whether sleep disorders accelerate the progress of ALS and shorten the survival time of ALS patients.

NCT ID: NCT04952012 Recruiting - Clinical trials for Thyroiditis, Autoimmune

The Effect of Thyroid Antibodies on Female Reproductive Function and Pregnancy Outcomes

Start date: November 30, 2020
Phase:
Study type: Observational

Some women at reproductive age have positive antithyroid antibodies (ATAs). Thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb) are the most common ATAs. This study aimed to evaluate the impact of ATAs on maturation of women reproductive system and pregnancy outcomes.