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NCT ID: NCT05657951 Active, not recruiting - Clinical trials for Zonule of Zinn Abnormality

Repeatability and Reproducibility of Lens Zonule Length Measurement Using ArcScan Insight 100

Start date: August 1, 2022
Phase:
Study type: Observational

The purpose of this study is to evaluate the intra-examiner repeatability and inter-examiner reproducibility in lens zonule length measurements using very high-frequency (VHF) digital ultrasound (ArcScan Insight 100).

NCT ID: NCT05657652 Recruiting - Clinical trials for Acute Lymphoblastic Leukemia

CAV Regimen for R/R Ph- B-ALL

Start date: October 1, 2022
Phase: N/A
Study type: Interventional

This study aims to investigate the efficacy and safety of cladribine, venetoclax combined with cytarabine and venetoclax (CAV regimen) for relapsed/refractory (R/R) Philadelphia Chromosome-negative (Ph-) B-cell acute lymphoblastic leukemia (B-ALL).

NCT ID: NCT05657639 Recruiting - Clinical trials for Acute Myeloid Leukemia

CAV Regimen for R/R AML

Start date: October 1, 2022
Phase: Phase 2
Study type: Interventional

This study aims to investigate the efficacy and safety of cladribine, combined with low-dose cytarabine and venetoclax (CAV regimen) for relapsed/refractory acute myeloid leukemia (R/R AML).

NCT ID: NCT05657470 Recruiting - Stroke, Ischemic Clinical Trials

Rescue Thrombolysis for Medium Vessel Occlusion (RESCUE-TNK)

Start date: March 21, 2023
Phase: Phase 2/Phase 3
Study type: Interventional

The best reperfusion strategy for medium-sized vessel occlusion (MeVO) is not well established. Given the proven treatment effect of intra-arterial thrombolysis in patients with large vessel occlusion (LVO), the investigators hypothesized that intra-arterial tenecteplase (TNK) could increase the recanalization rate of MeVO and thus improve clinical outcome. The current study aimed to explore the safety and efficacy of intra-arterial TNK in patients with MeVO.

NCT ID: NCT05657457 Recruiting - Stroke, Ischemic Clinical Trials

Improving Neurological Outcome for Acute Basilar Artery Occlusion With Sufficient Recanalization After Thrombectomy by Intraarterial Tenecteplase (INSIST-IT)

Start date: March 21, 2023
Phase: Phase 3
Study type: Interventional

The potential benefit of intraarterial tenecteplase in acute basilar artery occlusion (BAO) patients with successful reperfusion following endovascular treatment (EVT) has not been studied. The current study aimed to explore the efficacy and safety of intraarterial tenecteplase in acute BAO patients with successful reperfusion after EVT.

NCT ID: NCT05657444 Recruiting - Stroke, Ischemic Clinical Trials

Intra-arterial Tenecteplase During First Thrombectomy Attempt for Acute Stroke (BRETIS-TNK II)

Start date: March 21, 2023
Phase: Phase 3
Study type: Interventional

A recent pilot study suggests intra-arterial tenecteplase (TNK) during the first pass of endovascular treatment (EVT) seems safe, may increase first-pass reperfusion and good outcome in acute ischemic stroke (AIS) patients with large vessel occlusion (LVO). The study aimed to determine the efficacy and safety of intra-arterial TNK administration during EVT in AIS-LVO patients.

NCT ID: NCT05657418 Not yet recruiting - Clinical trials for Advanced Pancreatic Cancer

A Clinical Study to Evaluate the Safety and Tolerability of JS107 in Advanced Pancreatic Cancer

Start date: December 30, 2022
Phase: Phase 1
Study type: Interventional

The purpose of this phase I clinical study was to evaluate the safety and tolerability of JS107 monotherapy and combination with Toripalimab in patients with Advanced pancreatic cancer.

NCT ID: NCT05657366 Not yet recruiting - Pancreatic Fistula Clinical Trials

Peritoneal Lavage on the Incidence of Pancreatic Fistula and Related Complications After Pancreatoduodenectomy

Start date: May 1, 2023
Phase: N/A
Study type: Interventional

As one of the possible strategies to prevent pancreatic fistula, peritoneal lavage is still widely used in clinical practice, but it lacks more evidence of evidence-based medicine and recommendations of guidelines. Some clinicians believe that routine flushing after pancreatoduodenectomy wastes medical resources and has a negative impact on patients' comfort. In this study, the investigators designed a multicenter prospective controlled trial to compare the effects of peritoneal lavage and natural drainage on the incidence of pancreatic fistula and related complications after pancreatoduodenectomy. To study the indications of peritoneal lavage.

NCT ID: NCT05657184 Completed - Clinical trials for Idiopathic Pulmonary Fibrosis

Treatment of Idiopathic Pulmonary Fibrosis(IPF) by REGEND001

Start date: July 19, 2021
Phase: Phase 1/Phase 2
Study type: Interventional

Idiopathic pulmonary fibrosis (IPF) is a serious chronic (long term) disease with injury of lung tissues. REGEND001 Autologous Therapy Product, made from bronchial basal cells with ability to regenerate lung tissue, is promising to IPF treatment. In this study, a single-armed clinical trial is ongoing to assess the safety and tolerability of REGEND001 Autologous Therapy Product in treatment of IPF. Different doses of REGEND001 Autologous Therapy Product is evaluated to establish a dose-response relationship and to recommend appropriate dose for subsequent clinical trials.

NCT ID: NCT05656963 Active, not recruiting - Thromboembolism Clinical Trials

The Influencing Factors and Mechanism of High Incidence of Thrombotic Events in Patients With MN and DKD

Start date: September 1, 2021
Phase:
Study type: Observational

Influence factors and preliminary mechanism of high incidence of thrombotic events in patients with idiopathic membranous nephropathy and diabetes kidney disease