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NCT ID: NCT01402908 Terminated - Cancer Clinical Trials

A Phase III PI-88 in the Adjuvant Treatment of Subjects With Hepatitis Virus Related HCC After Surgical Resection

PATRON
Start date: August 2011
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine if PI-88 is effective and safe in patients who have had surgery to remove primary liver cancer.

NCT ID: NCT01402219 Terminated - Clinical trials for Chronic Renal Disease

Nephrotoxicity of Iopamidol Versus Iodixanol in High-Risk Patients

NEIHR
Start date: November 2008
Phase: Phase 4
Study type: Interventional

The purpose of this study is to compare the incidence of contrast-induced nephropathy (CIN) following the administration of iopamidol-370 (Iopamiro-370) and iodixanol-320 (Visipaque 320) in patients with chronic kidney disease undergoing coronary angiography.

NCT ID: NCT01370057 Terminated - Scoliosis Clinical Trials

The Use of Thoraco-lumbo-sacral Orthoses (TLSOs) in the Treatment of Adolescent Idiopathic Scoliosis (AIS)

Start date: May 2011
Phase: N/A
Study type: Interventional

The purpose of this study is to compare the risk of curve progression in Adolescent Idiopathic Scoliosis for subjects treated with bracing as compared to those without bracing.

NCT ID: NCT01362608 Terminated - Gouty Arthritis Clinical Trials

Safety & Efficacy of Canakinumab (ACZ885) in Patients With Frequent Flares for Whom Nonsterodial Anti-Inflammatory Drug (NSAIDs) and/ or Colchicine Are Contraindicated, Not Tolerated or Ineffective

Start date: June 20, 2011
Phase: Phase 3
Study type: Interventional

The purpose of this pivotal Phase III study is to support the registration of canakinumab for the indication of gout in China, a replicate of global studies CACZ885H2356 & CACZ885H2357 by demonstrating in patients with frequent flares of gout for whom NSAIDs and/or colchicine are contraindicated, not tolerated or ineffective, canakinumab 150 mg s.c. given upon acute gout flares relieves the signs and symptoms and prevents recurrence of gout flares compared to triamcinolone acetonide 40 mg i.m.

NCT ID: NCT01361750 Terminated - Oesophageal Cancer Clinical Trials

The Effects of Gastric Tube on the Quality of Life and Nutritional Status After Ivor-Lewis Esophagectomy

Start date: May 2011
Phase: N/A
Study type: Interventional

This study is to investigate the effects of narrowed gastric tube on postoperative nutritional status and the quality of life in esophageal cancer patients treated with Ivor-Lewis esopagectomy in a 12-month follow-up period.

NCT ID: NCT01342016 Terminated - Lupus Nephritis Clinical Trials

A Study to Compare the Efficacy and Safety of Tacrolimus Capsules With Leflunomide Tablets in Lupus Nephritis Patients

Start date: April 2011
Phase: Phase 3
Study type: Interventional

The purpose of this study is to compare the efficacy and safety of tacrolimus capsules with leflunomide tablets in the treatment of lupus nephritis.

NCT ID: NCT01319669 Terminated - Clinical trials for Carcinoma, Non-Small-Cell Lung

Clinical Trial on the Prevention of Thrombocytopenia After First-line Chemotherapy

Start date: February 2011
Phase: Phase 2/Phase 3
Study type: Interventional

To assess the efficacy and safety of administration of rhTPO at different time in the treatment of thrombocytopenia caused by first-line GC/GP regimen for non small cell lung cancer (NSCLC)

NCT ID: NCT01308346 Terminated - Clinical trials for Coronary Artery Disease

ABSORB PHYSIOLOGY Clinical Investigation

Start date: November 2011
Phase: N/A
Study type: Interventional

The target enrollment goal for the trial was to enroll 36 subjects. However due to a challenging protocol inclusion/ exclusion criteria, only one subject was enrolled since the trial was initiated in June 2011. To evaluate the following in participants undergoing coronary artery scaffolding/stenting for significant coronary artery disease: - The acute (post-implantation) effect of an implanted bioresorbable vascular scaffold (BVS) or metallic drug eluting stent (mDES) on coronary blood flow and physiological responsiveness of the target coronary artery - The long-term (2 years) effect of an implanted BVS or mDES on coronary blood flow and physiological responsiveness of the target coronary artery

NCT ID: NCT01301911 Terminated - Breast Cancer Clinical Trials

Study of Cipatinib in Patients With HER2 Positive or Uncertain Advanced Breast Cancer

Start date: January 2011
Phase: Phase 1
Study type: Interventional

Cipatinib is an oral tyrosine kinase inhibitor targeting both HER-1 and HER-2 receptors. This study is designed to evaluate the safety and tolerability of cipatinib in patients with HER2 positive or uncertain advanced breast cancer: 1. To evaluate the safety and tolerability of cipatinib, and the maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) 2. To determine the pharmacokinetic profile of cipatinib and its metabolites 3. To assess preliminary antitumor activity 4. To determine preliminary regimen for phase II study 5. To determine the relation of expression of HER-1 and HER-2 to the antitumor activity.

NCT ID: NCT01287741 Terminated - Clinical trials for Diffuse Large B-Cell Lymphoma

A Study of Obinutuzumab in Combination With CHOP Chemotherapy Versus Rituximab With CHOP in Participants With CD20-Positive Diffuse Large B-Cell Lymphoma (GOYA)

Start date: July 26, 2011
Phase: Phase 3
Study type: Interventional

This open-label, randomized, parallel group study will evaluate the efficacy and safety of obinutuzumab in combination with cyclophosphamide, doxorubicin, vincristine, and prednisolone or prednisone (CHOP) chemotherapy versus rituximab (MabThera/Rituxan) with CHOP in previously untreated participants with cluster of differentiation 20 (CD20)-positive diffuse large B-cell lymphoma (DLBCL). Participants will be randomized to receive either obinutuzumab 1000 milligrams (mg) intravenously (IV) every 21 days or rituximab 375 milligrams per square meter (mg/m^2) IV every 21 days for 8 cycles, in addition to 6-8 cycles of CHOP chemotherapy IV every 21 days. Participants randomized to the obinutuzumab arm will receive an additional two doses on Days 8 and 15 of Cycle 1. Anticipated time on study treatment is 24 weeks.