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NCT ID: NCT05960552 Recruiting - Clinical trials for Transesophageal Echocardiography

Perioperative Rescue Transesophageal Echocardiography in Intensive and Critical Status

Start date: August 1, 2023
Phase: N/A
Study type: Interventional

We initiate this study to assess the diagnostic efficiency of PReTEE, a simplified TEE scan sequence with a combination of 3 valuable views of ME 4C, ME AV LAX and TG SAX, in identifying cardiac pathologies in the phase of difficult cardiopulmonary bypass separation among patients who will undergo high-risk cardiac surgical procedures.

NCT ID: NCT05960032 Completed - Healthy Clinical Trials

A Study to Learn About the Study Medicine Called Zavegepant in Healthy Chinese Adult Participants

Start date: October 23, 2023
Phase: Phase 1
Study type: Interventional

The purpose of this study is to learn about: - how Zavegepant is changed and removed from the body after taken. - safety of Zavegepant. - the extent to which side effects can be tolerated after taking Zavegepant for the possible short-term treatment of migraine. This study is seeking participants who: - are healthy Chinese adults and includes participants who are between 18 to 55 years old. - have body mass index (BMI) of 18 to 30 kg/m^2. - have a total body weight of: - equal to or more than 50 kilograms (110 pounds) for males. - equal to or more than 45 kilograms (99 pounds) for females. - are non-smoker (no use of tobacco or nicotine products). All participants in this study will receive Zavegepant by nose, once at the study clinic. The experiences of the participants receiving the study medicine will be looked at. This will help see if the study medicine is safe. Participants will take part in this study for around 9 weeks. During this time, participants will have 2 study visits at the study clinic and 1 contact over the phone.

NCT ID: NCT05959941 Recruiting - Healthy Clinical Trials

A Study of Macitentan in Healthy Chinese Adult Male Participants

Start date: July 5, 2023
Phase: Phase 1
Study type: Interventional

The purpose of this study is to assess what macitentan and its active metabolite (aprocitentan) does to the body after single dose administration of macitentan in Chinese healthy adult male participants.

NCT ID: NCT05959863 Recruiting - Clinical trials for Primary Aldosteronism

Primary Aldosteronism LC-MS/MS-specific Cutoffs

PM
Start date: August 30, 2023
Phase:
Study type: Observational

Aims to evaluation the LC-MS/MS-specific cutoffs of PA screening and CCT test.

NCT ID: NCT05959759 Not yet recruiting - Clinical trials for Intracranial Aneurysm

Dimethyl Fumarate Treatment for Intracranial Unruptured Aneurysms.

Start date: July 31, 2023
Phase: Phase 4
Study type: Interventional

This study was designed to identify whether there is a measurable reduction in inflammation in walls of intracranial aneurysms with oral dimethyl fumarate.

NCT ID: NCT05959694 Recruiting - Clinical trials for Chronic Lymphocytic Leukemia

A Clinical Trial on the Safety and Efficacy of TQB3909 Tablets in Patients With Recurrent or Refractory Chronic Lymphocytic Leukemia (CLL) /Small Lymphocytic Lymphoma (SLL) .

Start date: October 11, 2023
Phase: Phase 1/Phase 2
Study type: Interventional

This is a phase Ib/II clinical trial to evaluate the safety and efficacy of TQB3909 tablets in patients with recurrent or refractory CLL/SLL.

NCT ID: NCT05959512 Not yet recruiting - Smoking Behaviors Clinical Trials

Smoking Pattern and Influencing Factors in Hospitalized Patients

Start date: July 19, 2023
Phase:
Study type: Observational

This study examines the smoking patterns and determinants of inpatients who smoke, develops tailored smoking cessation interventions based on their individual needs, and aims to enhance the effectiveness of quitting and lower the likelihood of relapse.

NCT ID: NCT05959356 Recruiting - Clinical trials for Metastatic Colorectal Cancer

Cetuximab and Envafolimab Plus mFOLFOXIRI as First-line Treatment for RAS/BRAF Wild-type, MSS, Unresectable Left-side Metastatic Colorectal Cancer

CEIL
Start date: November 9, 2023
Phase: Phase 2
Study type: Interventional

The primary aim of phase II CEIL study is to evaluate the efficacy of cetuximab and envafolimab plus mFOLFOXIRI versus cetuximab plus mFOLFOX6/FOLFIRI as first line treatment of patients with initially unresectable and previously untreated RAS/BRAF wild-type, MSS, left-side metastatic colorectal cancer(mCRC), in terms of Progression-free Survival.

NCT ID: NCT05959187 Completed - Depressive Disorder Clinical Trials

A Single-center Randomized Controlled Study on the Effect of Pharmacogenomics Trial on Clinical Efficacy in Patients With Depression

Start date: July 15, 2020
Phase: N/A
Study type: Interventional

The purpose of this clinical trial is to explore the efficacy of drug therapy under the guidance of pharmacogenomics test in the treatment of patients with depression. The main questions to be answered in this study are: 1. Whether the drug treatment regimen under the guidance of pharmacogenomics test is beneficial to the rehabilitation of patients with depression. 2. Pharmacogenomics tests whether it can reduce adverse drug reactions during treatment, and be evaluated by the scale before and after treatment. The researchers will compare the pharmacogenomics test group with the healthy control group to see the effect of drug therapy under the guidance of pharmacogenomics test on the efficacy of patients with depression.

NCT ID: NCT05959083 Active, not recruiting - Clinical trials for Atopic Dermatitis (AD)

Real World Study of Oral Upadacitinib Tablets to Assess Adverse Events and Change in Disease Activity in Adolescent and Adult Chinese Participants With Atopic Dermatitis

Start date: August 18, 2023
Phase:
Study type: Observational

Atopic dermatitis (AD) is a skin condition that may cause a rash and itching due to inflammation of the skin. This study will assess how safe and effective upadacitinib is in treating AD in adolescent and adult Chinese participants. Upadacitinib is an approved drug for treating AD. Approximately 200 adolescent and adult participants who are prescribed upadacitinib by their physician in accordance with local label will be enrolled in China. Participants will receive upadacitinib as prescribed by their physician according to their routine clinical practice and local label. Participants will be followed up for approximately 24 months per participant and 30 days after last treatment dose for safety data collection. There is expected to be no additional burden for participants in this trial. Participants will attend regular visits during the study at a hospital or clinic according to their routine clinical practice