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Intracranial Aneurysm clinical trials

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NCT ID: NCT03726463 Not yet recruiting - Clinical trials for Kidney Transplant; Complications

Evaluation of Iliac and Renal Artery for Mechanism of Intracranial Aneurysm in ADPKD

Start date: November 2018
Study type: Observational

ADPKD is the most common form of hereditary kidney disease and is known to occur in 1 of 400 to 1000 population in the U.S. ADPKD consists of 2.8% of patients receiving kidney transplantation in our center. It is known that ADPKD is associated with vascular anomalies, including abdominal aneurysms, valvular anomalies and especially intracranial aneurysms. Intracranial aneurysms occur in 9~12% of the ADPKD population which is higher than 2~3% in the general population and is known to be associated with PKD1 or PKD2 heritage. Until now, most of the studies regarding intracranial aneurysms in ADPKD are conducted in animal models, and there are only few cellular studies conducted from human samples. While performing kidney transplantation to ESRD ADPKD patients, arterial tissues from nephrectomy specimens can be obtained. The objective of this study is to investigate the mechanism of intracranial aneurysm in ADPKD patients by analyzing iliac and renal artery characteristics.

NCT ID: NCT03680742 Recruiting - Clinical trials for Intracranial Aneurysm

Contour Neurovascular System - European Pre-Market Unruptured Aneurysm

Start date: September 18, 2018
Phase: N/A
Study type: Interventional

Cerus Endovascular is sponsoring a prospective, multi-center trial to document the safety and performance of the Contour Neurovascular Systemâ„¢ ("Contour"). The purpose of the study is to document safety and performance of the Contour in treatment for patients with intracranial aneurysms (IA). The data from the study will be reported as a Pre-Market study to the Notified Body to support CE Mark approval.

NCT ID: NCT03663257 Recruiting - Clinical trials for Intracranial Aneurysm

Study to Evaluate Cerebral AneurysmFlow Results in Occlusion

Start date: October 4, 2018
Study type: Observational

AneurysmFlow R1.0 is an approved (i.e. CE labeled, 510k, Health Canada), software tool intended to provide relevant information on the blood flow in a cerebral aneurysm and its parent artery based on angiography. It calculates the Mean Aneurysm Flow Amplitude (MAFA) ratio to measure the volumetric flow rate quotient before and after Flow Diverter Stent (FDS) implantation in the region of interest. The current study is a prospective, single arm, observational, multicenter cohort study to assess the prognostic value of the MAFA ratio for predicting full aneurysm occlusion 12 months after flow diverter placement.

NCT ID: NCT03661463 Not yet recruiting - Inflammation Clinical Trials

Unruptured Intracranial Aneurysm Aspirin Trial (UIAAT).

Start date: January 2019
Phase: Phase 2
Study type: Interventional

Does Aspirin reduce inflammation in the walls of unruptured brain aneurysms? Brain aneurysms are balloon-like outpouchings of a blood vessel resulting from a weakness in the vessel wall. They generally cause no symptoms, but can burst and cause a bleed in the brain, resulting in death or disability. Aneurysms occur in 1 in 30 people, but rarely burst, with 1 in 10,000 people having a brain bleed. Ideally, aneurysms would be treated before they burst to prevent bleeding in the brain. The two ways of treating aneurysms currently are both risky and invasive, and no medications have been shown to reduce the risk of aneurysms bursting. Aspirin is one of the most common medications, used worldwide to treat pain, fever and inflammation, and for the prevention of strokes and heart attacks. Its anti-inflammatory properties may be beneficial for patients with aneurysms. We know that the walls of burst aneurysms and aneurysms that are about to burst, are more inflamed than those that do not burst. Therefore, a drug that reduces inflammation may reduce the risk of an aneurysm bursting. We have designed this study to test whether there is a measurable reduction in inflammation in walls of brain aneurysms. In this study, participants known to have an aneurysm that is not planned for treatment and has not yet burst, take aspirin daily for three months, and have an MRI scan before and after to look for a reduction in inflammation. If this study is successful it would be the first step towards developing the first medication to help treat patients with aneurysms, representing a huge advance for the 2.1 million people in the UK with this condition.

NCT ID: NCT03655509 Active, not recruiting - Clinical trials for Subarachnoid Hemorrhage

Searching a Dysfunction of Corticotropic & Thyrotropin Axis During the Acute Phase of a Subarachnoid Hemorrhage Secondary to Spontaneous Rupture of Cerebral Aneurysm

Start date: June 2013
Phase: N/A
Study type: Interventional

Searching a dysfunction of corticotropic and thyrotropin axis during the acute phase ( ≤48h ) of a subarachnoid hemorrhage secondary to spontaneous rupture of cerebral aneurysm. Impact on the incidence of complications and recovery are evaluated at 1 month. Blood sample are made within 48 hours of the onset of bleeding with assay of total plasma cortisol, plasma ACTH at 8 am and thyroid hormones (T3, free T4 , and TSH). Dynamic test ACTH stimulation (test Synacthene) with renewal of serum cortisol to H + 1 (60min). Evaluation in the first 30 days of the incidence of rebleeding, hydrocephalus, of vasospasm, infection and epilepsy. GOS to 1 month.

NCT ID: NCT03642821 Not yet recruiting - Clinical trials for Intracranial Aneurysm

Intracranial Aneurysms Treatment With the OPTIMA Coil System

Start date: October 2018
Study type: Observational [Patient Registry]

International, non-randomized, European , multicenter, observational study to collect data for the treatment of intracranial aneurysms with OPTIMA coils system to further document its safety and efficacy

NCT ID: NCT03642639 Not yet recruiting - Aneurysms Clinical Trials

A Study to Look at Performance of MICRUSFRAME and GALAXY Coils for the Treatment of Intracranial Aneurysms

Start date: August 31, 2018
Phase: N/A
Study type: Interventional

A post-market registry evaluating ruptured/unruptured aneurysms treated exclusively with Spectra Galaxy and Spectra Micrusframe coils

NCT ID: NCT03632902 Recruiting - Airway Management Clinical Trials

Airway Management With Supraglottic Devices in Unruptured Intracranial Aneurysms

Start date: June 26, 2018
Study type: Observational

Endovascular techniques for the treatment of intracranial aneurysms are growing.

NCT ID: NCT03581409 Recruiting - Clinical trials for Endovascular Procedures

Comparison of Two Different Antiplatelet Preparations for an Unruptured Intracranial Aneurysm

Start date: October 24, 2018
Phase: Phase 4
Study type: Interventional

Perform a randomized comparison study of dual-antiplatelet (aspirin, prasugrel) and triple-antiplatelet (aspirin, clopidogrel, and cilostazol) preparation using P2Y12 assay in patients with high on-treatment platelet reactivity undergoing stent-assisted coil embolization for an unruptured intracranial aneurysm

NCT ID: NCT03553771 Recruiting - Clinical trials for Intracranial Aneurysm

Safety and Efficacy of the LVIS and LVIS JR Devices in the Endovascular Treatment of Intracranial Aneurysms

Start date: February 7, 2018
Study type: Observational

A French, multicenter, prospective, observational, "real life" assessment of the safety and efficacy of LVIS and LVIS JR devices in the treatment of intracranial aneurysms