Clinical Trials Logo

Intracranial Aneurysm clinical trials

View clinical trials related to Intracranial Aneurysm.

Filter by:

NCT ID: NCT03920358 Recruiting - Clinical trials for Intracranial Aneurysm

FRED/FRED Jr Intracranial Aneurysm Treatment Study

FRITS
Start date: April 10, 2019
Phase:
Study type: Observational

A prospective, multicenter, observational evaluation of the safety and efficacy of the FRED® device in the treatment of intracranial aneurysms

NCT ID: NCT03916133 Recruiting - Ischemic Stroke Clinical Trials

Analysis of Selective Cerebrovascular Distribution With FDCT in the Angiosuite

Start date: June 1, 2018
Phase: N/A
Study type: Interventional

The aim of this study is to evaluate the clinical feasibility of the angiographic Flat Detector CT perfusion imaging (6s PBV) technique. The investigators will examine the specific vessel distribution of patients with steno-occlusive disease, treated with a surgical extracranial-intracranial bypass and assess the cerebral perfusion during test occlusion upon a neurovascular treatment and in intracranial tumor patients referred for potential pre-operative embolization. This study encompasses three scientific objectives: 1. What is the selective contribution of an individual bypass artery to the brain perfusion? 2. Is a selective intra-arterial angiographic perfusion examination useful in the decision-making of performing pre-operative embolization of intracranial tumors? 3. What is the usefulness of performing additive 6s PBV images compared to classical 2D angiography and/or clinical neurological evaluation in case of test occlusion in the evaluation of possible mother vessel occlusion in treatment of complex neurovascular diseases?

NCT ID: NCT03894202 Not yet recruiting - Clinical trials for Subarachnoid Hemorrhage

Impact of Ultra-Early Intracranial Aneurysm Treatment in SAH

UEAT
Start date: August 1, 2019
Phase:
Study type: Observational

This is the first prospective study in Hong Kong that recruit patients with poor neurological status after intracranial aneurysm rupture in all seven public neurosurgical services in Hong Kong. This study assesses whether ultra-early aneurysm treatment improves outcomes in patients with poor neurological status after intracranial aneurysm rupture in Hong Kong. These data are essential to understand the impact of the disease and for future service development in Hong Kong.

NCT ID: NCT03889392 Completed - Clinical trials for Kidney Transplant; Complications

Evaluation of Nephrectomy Specimen for Intracranial Aneurysm Development in ADPKD

Start date: January 1, 1994
Phase:
Study type: Observational

ADPKD is the most common form of hereditary kidney disease and is known to occur in 1 of 400 to 1000 population in the U.S. ADPKD consists of 2.8% of patients receiving kidney transplantation in the investigator's center. It is known that ADPKD is associated with vascular anomalies, including abdominal aneurysms, valvular anomalies and especially intracranial aneurysms. Intracranial aneurysms occur in 9~12% of the ADPKD population which is higher than 2~3% in the general population and is known to be associated with PKD1 or PKD2 heritage. Until now, most of the studies regarding intracranial aneurysms in ADPKD are conducted in animal models, and there are only few cellular studies conducted from human samples. Total 154 patients received kidney transplantation for ADPKD from 1994 to December 2018 at Asan Medical Center, Seoul, Korea. While performing kidney transplantation to ESRD ADPKD patients, nephrectomy has been routinely performed for polycystic kidney and the nephrectomy specimens can be obtained. The objective of this study is to investigate the mechanism of intracranial aneurysm in ADPKD patients by analyzing gene characteristics from nephrectomy specimens.

NCT ID: NCT03888014 Not yet recruiting - Brain Tumor Clinical Trials

Intraoperative Fluorescence With Augmented Reality

Start date: March 2019
Phase:
Study type: Observational

This is a study looking at a new way to evaluate vascular problems or tumors in brain surgery patients using a standard & approved intravenous dye and augmented reality.

NCT ID: NCT03873714 Not yet recruiting - Clinical trials for Intracranial Aneurysm

Pipeline™ Flex Embolization Device With Shield Technology™ for Wide-Necked Intracranial Aneurysms (ADVANCE)

ADVANCE
Start date: July 2019
Phase: N/A
Study type: Interventional

The purpose of this study is to assess the safety and effectiveness of the Pipeline™ Shield™ device in the treatment of unruptured or ruptured, wide-necked intracranial aneurysms.

NCT ID: NCT03852680 Not yet recruiting - Brain Aneurysm Clinical Trials

Current Treatment Modalities for Wide Necked Intracranial Aneurysms

Start date: March 1, 2019
Phase: N/A
Study type: Interventional

- Give an effective treatment for intracranial wide necked aneurysm and can detect the best method could be used. - Improve the outcome of these patients and decease rate of recurrence and complications.

NCT ID: NCT03844334 Recruiting - Brain Aneurysm Clinical Trials

CLinical EValuation of WEB 0.017 Device in Intracranial AneuRysms

CLEVER
Start date: March 21, 2019
Phase:
Study type: Observational

The study is an observational, European, multi-center, prospective assessment of the clinical utility of the 0.017 WEB Aneurysm Embolization System in subjects with intracranial aneurysms deemed appropriate for endovascular treatment.

NCT ID: NCT03831672 Recruiting - Clinical trials for Intracranial Aneurysm

Post Market Multi-Center Retrospective Research on Embolization of Intracranial Aneurysms With Pipeline Embolization Device in China

PLUS
Start date: November 1, 2018
Phase:
Study type: Observational

Pipeline TM embolization device launched to China in 2014, and has been widely used to treat large width IA. Therefore, it is necessary to collect and analysis the clinical data to evaluate effectiveness and safety of its usage in Chinese population, and this may guide the clinical practice and meet the clinical needs better.

NCT ID: NCT03823482 Enrolling by invitation - Aneurysm, Cerebral Clinical Trials

Lidocaine and Perioperative Cytokine Levels in Blood and Cerebrospinal Fluid in Cerebral Aneurysm Patients

Start date: March 1, 2019
Phase: N/A
Study type: Interventional

Cerebral aneurysm surgery has significant mortality and morbidity rate. Inflammation plays a key role in the pathogenesis of intracranial aneurysms, their rupture, subarachnoid haemorrhage and neurologic complications. Brain injury activates immune cells and triggers cytokine release. Cytokine level in blood and cerebrospinal fluid is an indicator of inflammatory response. Cytokines contribute to secondary brain injury and can worsen the outcome of the treatment. Preventing secondary brain injury by modulating inflammatory response represents a therapeutic target. Lidocaine is local anesthetic that can be used in neurosurgery for regional anesthesia of the scalp and for topical anesthesia of the throat prior to direct laryngoscopy and endotracheal intubation. Except analgetic, lidocaine has systemic anti-inflammatory and neuroprotective effect. It acts through several mechanisms on various types of immune cells producing immunosuppressing effect. Lidocaine can act on activated microglia within central nervous system causing attenuation of immune response. Primary aim of this prospective randomized trial is to determine influence of lidocaine administration on inflammatory cytokine levels in serum and cerebrospinal fluid during and following cerebral aneurysm surgery. Secondary aim is to determine possible correlation between levels of cytokines and incidence of neurologic and infectious postoperative complications. For that purpose, postoperative neurological clinical status will be recorded. Signs of vasospasm and pathological postoperative brain CT scan findings will be recorded. Incidence of meningitis, pneumonia and sepsis in postoperative period will also be analyzed. Hypothesis of this trial is that lidocaine administration during cerebral aneurysm surgery would significantly change levels of pro-inflammatory cytokines in cerebrospinal fluid and serum. Lower concentrations of pro-inflammatory cytokines can possibly contribute to better outcome and significantly lower incidence of postoperative complications. Enzyme-immunochemical analysis will be used to measure levels of interleukin-1β, interleukin-6 and tumor necrosis factor-α in cerebrospinal fluid and serum. Investigation group will have, during cerebrovascular surgery under general anesthesia, regional anesthesia of the scalp and topical anesthesia of the throat prior to laryngoscopy, all done with lidocaine. Control group will have general anesthesia without lidocaine administration.