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NCT ID: NCT05649540 Recruiting - Clinical trials for Helicobacter Pylori Infection

Optimization of Vonoprazan-based Dual Therapy for Helicobacter Pylori

Start date: January 20, 2023
Phase: Phase 4
Study type: Interventional

The purpose of this study was to evaluate the efficacy and safety of vonoprazan with different doses of amoxicillin for Helicobacter Pylori.

NCT ID: NCT05649488 Recruiting - Clinical trials for Coronary Artery Disease

Evaluate the Safety and Efficacy of Intracoronary Lithotripsy Balloon Catheter and Intracoronary Lithotripsy Apparatus

Start date: February 9, 2023
Phase: N/A
Study type: Interventional

This is a prospective, multi-center, single-group target value clinical trial, which will be carried out in many clinical trial institutions in China. A total of 184 subjects (70 of them are OCT subgroups) are planned to be enrolled, all subjects were treated surgically with intracoronary lithotripsy using a balloon dilatation catheter and intracoronary lithotripsy apparatus after a single-group registration, clinical follow-up was carried out within 7 days after operation or before discharge, 1 month and 6 months after operation. The success rate of operation was taken as the main end point to verify the effectiveness of balloon dilatation catheter and intracoronary lithotripsy apparatus.

NCT ID: NCT05649475 Recruiting - Clinical trials for Stage I-III Breast Cancer

Circulating Tumor DNA Monitoring in Breast Cancer Undergoing Neoadjuvant Therapy

Start date: August 31, 2021
Phase:
Study type: Observational

In the prospective, open, observational study, we aim to evaluate whether circulating tumor DNA (ctDNA) can be the marker of the response to neoadjuvant therapy in stage I-III breast cancer.

NCT ID: NCT05649345 Recruiting - Clinical trials for Advanced Solid Tumor

TR64 in Patients With Advanced Solid Tumors

Start date: January 12, 2023
Phase: Phase 1
Study type: Interventional

This is a open-label, dose escalation, accelerated titration combined 3+3 design, phase I study, to evaluate the safety and tolerability, and to determine the RP2D of TR64 when administered qd in patients with advanced solid tumors. Up to 6 cohorts of 1-6 or 3-6 patients each will be treated in the study.

NCT ID: NCT05648968 Recruiting - Clinical trials for Warm Autoimmune Hemolytic Anemia (wAIHA)

A Study of Efficacy and Safety of Ianalumab in Previously Treated Patients With Warm Autoimmune Hemolytic Anemia

VAYHIA
Start date: December 30, 2022
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate efficacy and safety of ianalumab compared to placebo in patients with warm autoimmune hemolytic anemia, who failed at least one line of treatment.

NCT ID: NCT05648825 Recruiting - Clinical trials for Apical Hypertrophic Cardiomyopathy

Transapical Beating-heart Myectomy for the Treatment of Apical Hypertrophic Cardiomyopathy

Start date: November 15, 2022
Phase: N/A
Study type: Interventional

The primary purpose of this study is to evaluate the feasibility, the safety and the efficacy of the transapical beating-heart myectomy for the treatment of apical hypertrophic cardiomyopathy. This is a prospective, single-arm, single-center study.

NCT ID: NCT05648760 Recruiting - Clinical trials for Simulation of Physical Illness

Simulation-based Training Improves Competency in Communicating Bad News

Start date: December 12, 2022
Phase: N/A
Study type: Interventional

Delivering bad news is a task that doctors encounter daily in most medical practices, especially in Intensive Care Unit, where morbidity and mortality are high. The objective of this project was to demonstrate effectiveness of an educational program using simulation-based training intervention to teach medical students to deliver bad news and communicate more effectively with families.

NCT ID: NCT05648669 Recruiting - Endometriosis Clinical Trials

A Study to Evaluate Safety and Efficacy of Elagolix in Patients With Moderate to Severe Endometriosis-Associated Pain

Start date: September 4, 2022
Phase: Phase 3
Study type: Interventional

This is a Phase 3, multicenter, double-blind, placebo-controlled, randomized study to assess the safety and efficacy of elagolix versus placebo in premenopausal 18 to 49 year old women with moderate to severe endometriosis-associated pain.

NCT ID: NCT05648552 Recruiting - Stroke Clinical Trials

Altered Structural-functional Connectivity Coupling on Chronic Subcortical Stroke

Start date: January 1, 2022
Phase:
Study type: Observational

The current study aims to reveal the SC-FC coupling pattern and its relationship with motor function in post-stroke survivors with motor dysfunction by multimodal MRI.

NCT ID: NCT05648539 Recruiting - Depression, Anxiety Clinical Trials

Effect of Music Therapy in Mental Subhealth (EMTMS)

Start date: April 19, 2023
Phase: N/A
Study type: Interventional

Mental health is increasingly at the forefront of concerns, especially since the start of COVID-19 pandemic. However, not all individuals under mental subhealth need pharmaceutical treatment. Music Therapy (MT) can make peoples gradually relax via relaxing and soothing music, and regulate individual psychological emotions through the influence of music on individuals' cerebral cortex, hypothalamus and limbic system, further improve the mood of daily tension and anxiety. This study adopted randomized clinical trials design, with two groups of MT group and Waiting group both under mental subhealth. The MT group received music therapy and routine activities, while the Waiting group received music therapy after the therapy of MT group. Data collections were performed by trained, certified, and qualified personnel. The study aims to provide that MT is an effective intervention way to alleviate the mental subhealth state in the future.