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NCT ID: NCT06195995 Recruiting - Gambling Clinical Trials

Brain Mechanism and Intervention of Executive-control Dysfunction Among Gambling Disorder

Start date: January 15, 2024
Phase: N/A
Study type: Interventional

The investigators assume that transcranial Alternating Current Stimulation (tACS) could improve gambling disorder patients' executive-control function by adjusting the synchronization patterns and enhancing the functional connectivity of the prefrontal-ventral striatum pathway. This study intends to test the effect of tACS treatment. Three-month follow-up assessment will be conducted to test the changing of the executive-control function and its mechanism.

NCT ID: NCT06195917 Recruiting - Liver Diseases Clinical Trials

Robotic-assisted Percutaneous Transhepatic Puncture

Start date: September 19, 2023
Phase: N/A
Study type: Interventional

This is a first-in-man study to investigate the feasibility and safety profile of the newly developed robotic system for percutaneous transhepatic interventional procedures, including biopsy and ablation. Participants who were clinically assessed in need of a liver lesion puncture were included in this study.

NCT ID: NCT06195228 Recruiting - Clinical trials for Advanced Thyroid Cancer Patients Who Received Target Therapy

A Retrospective and Prospective Real-world Study of Molecular Typing in the Treatment of Advanced Thyroid Cancer

Start date: January 1, 2020
Phase: Phase 4
Study type: Interventional

This is a retrospective and prospective real-world clinical study of molecular typing in the treatment of advanced thyroid cancer. The retrospective study : Patients with advanced thyroid cancer who received precise treatment in our hospital from January 2020 to December 2023 were retrieved. The number of previous treatment lines was not limited. Patients who met the inclusion criteria were screened according to the inclusion and exclusion criteria. Demographic information, clinical characteristics, tumor treatment history, medication regimen, adverse reactions, molecular test results, survival follow-up results and other data were collected. The prospective study : Patients with advanced thyroid cancer who received precise treatment in our hospital from January 2024 to April 2027 were enrolled.

NCT ID: NCT06195202 Recruiting - Breast Cancer Clinical Trials

Serum Estradiol (E2) Levels in Breast Cancer Patients During Endocrine Therapy by High Performance Liquid Chromatography-tandem Mass Spectrometry (LC-MS /MS)

Start date: September 1, 2023
Phase:
Study type: Observational [Patient Registry]

The investigators intend to conduct a prospective cohort study to detect E2 levels during endocrine therapy in Chinese breast cancer patients using LC-MS/MS methods, and to determine the proportion of patients with premenopausal E2 levels (OFR or E2 insufficiency) during AIs or FUL endocrine therapy. To further explore the correlation between serum E2 levels and the efficacy of endocrine therapy in Chinese patients, so as to ensure the safety and efficacy of endocrine therapy for patients, and pave the way for further providing more accurate individualized treatment programs.

NCT ID: NCT06195189 Recruiting - Clinical trials for Non Small Cell Lung Cancer

Sunvozertinib Combined With Chemotherapy for EGFRm After EGFR-TKI Treatment Failure:Phase I/II

WU-KONG36
Start date: February 29, 2024
Phase: Phase 1/Phase 2
Study type: Interventional

To access the anti-tumor efficacy, safety and tolerability of Sunvozertinib combined with chemotherapy in patients with locally advanced or metastatic non-small-cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) sensitizing mutations who have progressed following standard TKI therapy.

NCT ID: NCT06195124 Recruiting - Clinical trials for Advanced Parkinson's Disease

A Study on the Safety and Tolerability of RGL-193 in Patients With Advanced Parkinson's Disease

Start date: December 2023
Phase: Early Phase 1
Study type: Interventional

A safety study in patients with Parkinson's disease.

NCT ID: NCT06194981 Recruiting - Gastric Cancer Clinical Trials

Duration of Adjuvant Chemotherapy for Gastric Cancer Patients at Pathological N3 Stage

Start date: January 11, 2024
Phase:
Study type: Observational

The goal of this retrospective study is to compare the efficacy and safety of 3-4 months to 5-6 months of CapOx/SOX adjuvant chemotherapy in pathological N3 gastric cancer patients.

NCT ID: NCT06194968 Recruiting - Clinical trials for Acute Ischemic Stroke

Treatment of Acute Ischemic StroKe With Intravenous UroKinase Real-world Research: a Multicenter, Prospective Study

Start date: December 30, 2023
Phase:
Study type: Observational

The purpose of this study is to to compare the safety and effectiveness of IV urokinase with IV alteplase in the treatment of AIS in patients up to 6 hours from symptom onset.

NCT ID: NCT06194825 Recruiting - Clinical trials for Transthyretin Amyloid Cardiomyopathy

EPIC-ATTR: A Study to Evaluate the Effect of Eplontersen on the Transthyretin Reduction and Long-term Safety in Chinese Subjects With Transthyretin Amyloid Cardiomyopathy

EPIC-ATTR
Start date: December 1, 2023
Phase: Phase 3
Study type: Interventional

The purpose of this study is to investigate the effect of eplontersen compared to placebo on the reduction of serum TTR concentration and long-term safety in Chinese participants with hereditary or wild-type transthyretin amyloid cardiomyopathy.

NCT ID: NCT06194734 Recruiting - Clinical trials for Esophageal Squamous Cell Carcinoma

A Study of KC1036 Versus Investigator's Choice of Chemotherapy in Patients With Advanced Esophageal Cancer

Start date: February 5, 2024
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the efficacy and safety of KC1036 versus investigator's choice of chemotherapy in patients with advanced recurrent or metastatic esophageal squamous cell carcinoma