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NCT ID: NCT04849195 Active, not recruiting - Clinical trials for Cardiovascular Diseases

Comparison of Different Feature Engineering Methods for Automated ICD Coding

Start date: March 1, 2021
Phase:
Study type: Observational

Using traditional machine learning classifiers, this study targets on comparing bag-of-words, word2cec and roberta on automated ICD coding related to cardiovascular diseases in Chinese corpus.

NCT ID: NCT04848753 Active, not recruiting - Clinical trials for Resectable Locally Advanced Thoracic Esophageal Squamous Cell Carcinoma

Perioperative Toripalimab (JS001) Combined With Neoadjuvant Chemotherapy in Patients With Resectable Locally Advanced Thoracic Esophageal Squamous Cell Carcinoma

Start date: June 23, 2021
Phase: Phase 3
Study type: Interventional

This is a randomized, placebo-controlled, multi-center, double-blinded, Phase III study to determine the efficacy and safety of patients with locally advanced squamous cell carcinoma of the thoracic esophagus treated with perioperative immunotherapy combined with neoadjuvant chemotherapy versus placebo combined with neoadjuvant chemotherapy.

NCT ID: NCT04847557 Active, not recruiting - Obesity Clinical Trials

A Study of Tirzepatide (LY3298176) in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF) and Obesity: The SUMMIT Trial

Start date: April 20, 2021
Phase: Phase 3
Study type: Interventional

The main purpose of this study is to assess the efficacy and safety of Tirzepatide (LY3298176) in participants with heart failure with preserved ejection fraction and obesity.

NCT ID: NCT04846868 Active, not recruiting - Schizophrenia Clinical Trials

Clinical Trial of Iclepertin Effect on Cognition and Functional Capacity in Schizophrenia (CONNEX-1)

Start date: June 16, 2021
Phase: Phase 3
Study type: Interventional

This study is open to adults with schizophrenia. Schizophrenia can affect the way a person thinks, their memory and their mental functioning. Examples include struggling to remember things, or to read a book or pay attention to a movie. Some people have difficulty calculating the right change or planning a trip so that they arrive on time. The purpose of this study is to find out whether a medicine called Iclepertin improves learning and memory in people with schizophrenia. Participants are put into two groups randomly, which means by chance. One group takes Iclepertin tablets and the other group takes placebo tablets. Placebo tablets look like Iclepertin tablets but do not contain any medicine. Participants take a tablet once a day for 26 weeks. In addition, all participants take their normal medication for schizophrenia. During this time, doctors regularly test learning and memory of the participants by use of questionnaires, interviews, and computer tests. The results of the mental ability tests are compared between the groups. Participants are in the study for about 8 months and visit the study site about 14 times. During this time, doctors regularly check participants' health and take note of any unwanted effects.

NCT ID: NCT04845139 Active, not recruiting - Clinical trials for Primary Central Nervous System Lymphoma

A Case Study of Nivolumab for Relapsed/Refractory Primary Central Nervous System Lymphoma

Start date: July 2, 2022
Phase: N/A
Study type: Interventional

The purpose of this study is to determine whether Nivolumab given intrathecally is effective in the treatment of Relapsed/Refractory Primary Central Nervous System Lymphoma (PCNSL)

NCT ID: NCT04844385 Active, not recruiting - Clinical trials for Esophageal Squamous Cell Carcinoma

Toripalimab Plus Neoadjuvant Chemotherapy Combined With Chemoradiotherapy for Locally Advanced Unresectable Esophageal Squamous Cell Carcinoma

Start date: February 20, 2021
Phase: Phase 2
Study type: Interventional

This Phase II non-randomized study is to determine the efficacy and toxicity of neoadjuvant toripalimab plus chemotherapy followed by chemoradiotherapy for locally advanced unresectable esophageal squamous cell carcinoma.

NCT ID: NCT04842032 Active, not recruiting - Clinical trials for X-linked Hypophosphatemia (XLH)

Study to Assess the Safety, Pharmacokinetics and Efficacy of KRN23 in Pediatric Chinese Patients With XLH

Start date: November 1, 2021
Phase: Phase 4
Study type: Interventional

The purpose of this study is to assess the safety, pharmacokinetics and efficacy of KRN23 in pediatric Chinese patients with XLH

NCT ID: NCT04842019 Active, not recruiting - Clinical trials for X-linked Hypophosphatemia (XLH)

Study to Assess the Safety, Pharmacokinetics and Efficacy of KRN23 in Adult Chinese Patients With XLH

Start date: September 28, 2021
Phase: Phase 4
Study type: Interventional

The purpose of this study is to assess the safety, pharmacokinetics and efficacy of KRN23 in adult Chinese patients with XLH

NCT ID: NCT04836897 Active, not recruiting - Clinical trials for Aortic Valve Stenosis

PrizValve® Transcatheter Aortic Valve Replacement Study

Start date: January 19, 2021
Phase: N/A
Study type: Interventional

The purpose of this clinical study is to evaluate the effectiveness and safety of the transcatheter aortic valve system in the treatment of patients with severe aortic stenosis who are at high risk of surgery or who are not suitable for surgery.

NCT ID: NCT04835324 Active, not recruiting - Clinical trials for Advanced Colorectal Cancer

Regorafenib Treatment Patterns and Survival Outcomes in Advanced Colorectal Cancer: A Real-world Study

Start date: October 1, 2020
Phase:
Study type: Observational

This is a multi-center, retrospective, real-world study. The purpose of this study is to observe the effectiveness and safety of regorafenib in Chinese advanced colorectal cancer patients. The main observational goals include overall survival(OS), 6 month OS rate, 1 year OS rate, and treatment time failure (TTF), other study goals include objective response rate( ORR)、Disease control rate(DCR)and adverse event(AE) of regorafenib.