There are about 28871 clinical studies being (or have been) conducted in Canada. The country of the clinical trial is determined by the location of where the clinical research is being studied. Most studies are often held in multiple locations & countries.
Braces have been used o treat stable (not requiring surgery) burst fractures with much success. Recently questions have been raised in regards to the importance of the brace. Some studies have results that suggest a brace is not important in having a good outcome. However, this has never been proven. This study is being conducted to see whether or not wearing a brace is important to having a good outcome.
The purpose of this cross-sectional study was to examine whether or not physical changes or adaptations occur in response pregnancy or to the higher intakes of folic acid from supplementation typically consumed during the reproductive period.
To assess the clinical value of iFR to characterize, without concomitant administration of hyperemic agents and outside a specified range of iFR values, coronary stenosis severity as determined with fractional flow reserve (FFR)
One of the biggest challenges of conducting research where the investigators follow people over a long period of time is keeping the participants involved. One of way that investigators may be able to improve participant involvement in research is to give participants the opportunity to complete their questionnaires online. Here's how the investigators think the Internet data collection system will help to keep participants involved and ultimately help to answer important questions about the effects of nutrition during pregnancy: 1. It will allow investigators to present complicated questionnaires in a way that doesn't confuse participants. For example, instead of telling participants to skip the remainder of a question if they answered no to the first part of the question, the ePRO system does the skipping for them. The result is less confusion, fewer questions to read, and less of the participant's time. 2. It provides a convenient way for participants to keep track of where to find the questionnaire, and how much they have already completed. Participants sometimes don't have time to answer all of the investigator's questions in one sitting. The ePRO system keeps track of how much participants have already done and it's ready to keep going whenever the participant has time. It also avoids the common problem of losing the questionnaires to the household paperwork pile, or worse to the recycling bin. 3. It provides timely reminders to participants. Study participants, and especially new moms, are busy and they forget to complete the questionnaires. The ePRO system can provide timely reminders encouraging participants to respond. 4. It helps participants complete the questionnaires accurately. The ePRO system has an automatic error detection ability that will alert participants to any questions they missed or completed incorrectly. Finding ways to keep participants involved in research is something that all researchers are concerned about, and ultimately it's a concern for all Canadians because the results of research are often used to make decisions about health care and the kinds of programs that governments provide. Losing any participant from the study reduces the ability of policy makers to take the best decisions and choices about what health services to fund with limited dollars. What the investigators propose is a study to determine whether Internet data entry really will keep participants involved in a longitudinal study. Previous studies have shown that the internet can be a useful tool for getting people to sign up for research and at least one small study showed that using Internet data entry can actually save money. But no researchers have actually tested whether it really does a better job than paper based questionnaires in terms of keeping participants involved. In order to answer this question, the investigators will randomly assign the current Alberta Pregnancy Outcomes and Nutrition study participants to either continue receiving the paper-based questionnaire or to start receiving the web-based surveys. The investigators will follow participants over three assessment occasions (over a period of 18 months) and observe any differences between the groups in their involvement. Because the investigators are randomly assigning participants to the two groups, differences in involvement will tell them about usefulness of Internet data entry as a participant retention tool.
The purpose of this study is to determine the immediate effects of cryotherapy on the lower extremity biomechanics during running.
Many older adults have difficulty walking. A wheelchair can improve their participation but older adults typically receive little wheelchair training. Structured training programs are effective but rely on multiple 1:1 sessions with a skilled clinician. EPIC WheelS combines 2 brief training sessions and a 4-week home training program delivered using a portable computer tablet and monitored by an expert trainer. This study investigates the feasibility and potential for using EPIC WheelS with older adult novice wheelchair users in Vancouver and Winnipeg, measuring the impact on wheelchair skill, safety and confidence compared to a control group receiving only cognitive training. Hypotheses: The investigators expect that the feasibility outcomes will be sufficiently robust to support conducting a subsequent multi-site RCT. The investigators also expect the EPIC WheelS training program will have a significant treatment effect with improvement in wheelchair mobility, compared to a control group.
This study will compare three different exercise programs in older adults who report difficulty walking and will determine if the programs improve walking.
To determine whether, on a background of optimal medical therapy, including ticagrelor, opening of all suitable narrowings or blockages found at the time of primary PCI for an acute heart attack is better than treating only the culprit lesion in patients with multi-vessel disease.
The study is designed to compare the clinical benefit following treatment with letrozole in combination with PD-0332991 versus letrozole in combination with placebo in postmenopausal women with ER(+)/HER2(-) advanced breast cancer who have not received prior systemic anti cancer therapies for their advanced/metastatic disease.
This open-label, multicenter, non-randomized study provided continued access to vemurafenib for eligible participants with BRAF V600 mutation-positive malignancy, who were previously enrolled and treated in an antecedent vemurafenib protocol and did not meet the protocol's criteria for disease progression, or were treated beyond progression and were still deriving clinical benefit (as assessed by investigator), and may have therefore potentially benefited from continued treatment with vemurafenib. Participants received treatment with oral vemurafenib at 960 milligrams (mg) twice daily (BID), 720 mg BID, or 480 mg BID, depending on the last dose in the antecedent protocol. Treatment continued until progression of disease or as long as the participant was deriving clinical benefit, as judged by the investigator (case-by-case decision with approval of the Medical Monitor), death, withdrawal of consent, unacceptable toxicity, loss to follow-up, or decision of the Sponsor to terminate the study, whichever occurred first.