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NCT ID: NCT00425321 Completed - Clinical trials for Rheumatoid Arthritis

Safety and Effectiveness Study of RWJ-445380 Cathepsin-S Inhibitor in Patients With Active Rheumatoid Arthritis Despite Methotrexate Therapy

Start date: December 2006
Phase: Phase 2
Study type: Interventional

The primary objective of the study is to evaluate the safety and tolerability of 100, 200, and 300 mg/day doses of RWJ-445380 for up to 12 weeks in patients with active Rheumatoid Arthritis despite methotrexate therapy.

NCT ID: NCT00424593 Completed - Clinical trials for Back Pain Without Radiation

Duloxetine Versus Placebo in Chronic Low Back Pain

Start date: January 2007
Phase: Phase 3
Study type: Interventional

The primary purpose of your participation in this study is to help answer the following research question, and not to provide you treatment for your condition. Whether duloxetine once daily can help patients with Chronic Low Back Pain. Patients who do not have their pain reduced by at least 30% by week 7 will be given 120 mg dose for the duration of the study. After the 13 week double blind period, patients randomized to placebo will switch to duloxetine 60 mg or 120 mg in the 41-week extension period.

NCT ID: NCT00424476 Completed - Clinical trials for Systemic Lupus Erythematosus

A Study of Belimumab in Subjects With Systemic Lupus Erythematosus (SLE)

BLISS-52
Start date: May 2007
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the efficacy, safety, tolerability, and impact on quality of life of two different doses of belimumab administered in addition to standard therapy in subjects with active, autoantibody-positive systemic lupus erythematosus (SLE) disease.

NCT ID: NCT00424190 Completed - Clinical trials for Bacterial Infections

Comparative Study of Ceftaroline vs. Vancomycin Plus Aztreonam in Adult Subjects With Complicated Skin Infections

cSSSI
Start date: February 2007
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine whether ceftaroline is effective and safe in the treatment of complicated skin infections in adults.

NCT ID: NCT00423891 Completed - Clinical trials for Hepatitis B, Chronic

A Study of Entecavir in Pediatric Patients With Chronic Hepatitis B Virus (HBV)-Infection

Start date: June 30, 2007
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this clinical study is to determine the appropriate doses of entecavir to use in children and adolescents. Safety, tolerability and efficacy will also be studied

NCT ID: NCT00423657 Completed - Clinical trials for Bacterial Infections

Comparative Study of Ceftaroline vs. Vancomycin Plus Aztreonam in Adult Subjects With Complicated Skin Infections

Start date: March 2007
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine whether ceftaroline is effective and safe in the treatment of complicated skin infections in adults.

NCT ID: NCT00422526 Completed - Preterm Birth Clinical Trials

Progesterone for Prevention of Preterm Birth in Women With Short Cervix: Randomized Controlled Trial

Start date: September 2003
Phase: Phase 3
Study type: Interventional

The aim of our study is to evaluate the effect of use of prophylactic vaginal progesterone on the incidence of severe preterm delivery, defined as delivery before 33+6 weeks in women with a short cervical length of 15mm.

NCT ID: NCT00422383 Completed - Clinical trials for Rheumatoid Arthritis

A Study of Retreatment With MabThera (Rituximab) in Combination With Methotrexate in Patients With Rheumatoid Arthritis (RA)

Start date: February 2006
Phase: Phase 3
Study type: Interventional

This study will evaluate the efficacy and safety of various treatment and retreatment regimens of MabThera. All patients will receive concomitant methotrexate, 10-25mg once weekly either orally or parenterally. The anticipated time on study treatment is 2+ years, and the target sample size is 100-500 individuals.

NCT ID: NCT00419835 Completed - Clinical trials for Macroalbuminuric Diabetic Nephropathy

Effect of Enalapril and Losartan Association Therapy on Proteinuria and Inflammatory Biomarkers in Diabetic Nephropathy: a Clinical Trial on Type 2 Diabetes Mellitus

Start date: May 2005
Phase: Phase 4
Study type: Interventional

Chronic kidney disease (CKD)has become a significant health problem worldwide. Strategies to decrease the rate of progression of this disease and reduce the number of patients needing dialysis or renal transplantation are urgently needed. In this study we wish to compare the effect of dual blockade of renin-angiotensin system (ACE inhibitors plus angiotensin II receptor blocker) compared to the effect of ACE inhibitor monotherapy in patients with diabetic chronic nephropathy.

NCT ID: NCT00419744 Completed - Clinical trials for Chronic Obstructive Pulmonary Disease

A Comparison of SYMBICORT® pMDI With Formoterol Turbuhaler® in Subjects With COPD

Start date: January 2007
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine if SYMBICORT® delivered via a pressurized metered-dose inhaler, referred to as a pMDI, is effective in preventing COPD exacerbations.