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NCT ID: NCT00504881 Completed - Epilepsy Clinical Trials

Brivaracetam as add-on Treatment in Adolescents and Adults Suffering From Epilepsy

Start date: October 2007
Phase: Phase 3
Study type: Interventional

This study will compare the safety and efficacy of Brivaracetam at flexible dose with Placebo in subjects suffering from Epilepsy.

NCT ID: NCT00504803 Completed - Clinical trials for Hematological Malignancies

Mesenchymal Stem Cell Infusion as Prevention for Graft Rejection and Graft-versus-host Disease

Start date: December 2006
Phase: Phase 2
Study type: Interventional

Mesenchymal Stem Cell Infusion as Prevention for Graft Rejection and Graft-Versus-Host Disease After Allogeneic Hematopoietic Cell Transplantation With Nonmyeloablative Conditioning from HLA-mismatched PBSC or cord blood: a Pilot Study

NCT ID: NCT00504556 Completed - Atrial Fibrillation Clinical Trials

A Study to Assess the Safety of a Potential New Drug in Comparison to the Standard Practice of Dosing With Warfarin for Non-valvular Atrial Fibrillation

Start date: June 2007
Phase: Phase 2
Study type: Interventional

This study is to assess the safety of a potential new drug DU-176b for the prevention of stroke/systemic embolic event (SEE) in individuals with non-valvular atrial fibrillation (AF). The duration is 3 months of treatment and a 30 day follow-up visit.

NCT ID: NCT00504543 Completed - Clinical trials for Kidney Transplantation

Efficacy, Safety and Tolerability of AEB071 Versus Cyclosporine in the Novo Renal Transplant Recipients

AEB071
Start date: July 2007
Phase: Phase 2
Study type: Interventional

This study will assess safety and efficacy of AEB071 combined with everolimus in a CNI-free (calcineurin inhibitor) regimen in renal transplant recipients.

NCT ID: NCT00503178 Completed - Bone Metastases Clinical Trials

Biological Imaging Guided Antalgic Radiotherapy of Bone Metastases (Phase II Trial)

Start date: April 1, 2006
Phase: Phase 2
Study type: Interventional

Highly selective irradiation requires accurate target definition by high-resolution three-dimensional imaging. Co-registration of FDG-PET and high-resolution CT might be the imaging modality of choice. This choice might target radiation therapy precisely to the intra-osseous volume that is responsible for pain and to spare selectively healthy bone in the vicinity of the metastasis. This strategy could result in equal anti-pain efficacy as conventional large volume radiotherapy, but could allow bone remodeling and preservation of bone structural strength in the vicinity and could lead to reduced toxicity to neighboring organs.

NCT ID: NCT00501852 Completed - Clinical trials for Chronic Obstructive Pulmonary Disease

Efficacy and Safety of Four Doses of Glycopyrronium Bromide (NVA237) in Patients With Stable Chronic Obstructive Pulmonary Disease (COPD), in Comparison to an Active Comparator Tiotropium

Start date: July 2007
Phase: Phase 2
Study type: Interventional

This study will assess the efficacy and safety of glycopyrronium bromide (NVA237) in patients with stable COPD, in comparison to an active comparator.

NCT ID: NCT00501722 Completed - Liver Cirrhosis Clinical Trials

Satavaptan Dose-Ranging Study in Hyponatraemic Patients With Cirrhotic Ascites

Hypo~CAT
Start date: April 2004
Phase: Phase 2
Study type: Interventional

The primary objective is to determine the optimal dose or range of doses of SR121463B for the treatment of ascites and the correction of hyponatraemia when used concomitantly with a standard dose regimen of spironolactone. The secondary objective is to determine the tolerability of different fixed doses of SR121463B over a 14 day treatment period in cirrhotic ascites. This Hypo~CAT study is followed by a single-blind, placebo-controlled, one-year long-term safety extension (Expo~CAT). The first extension is followed by another long-term study (PASCCAL-1).

NCT ID: NCT00501566 Completed - Liver Cirrhosis Clinical Trials

Satavaptan Dose-Ranging Study in Normonatraemic Patients With Cirrhotic Ascites

Normo~CAT
Start date: April 2004
Phase: Phase 2
Study type: Interventional

The primary objective is to determine the optimal dose or range of doses of SR121463B for the treatment of ascites when used concomitantly with a standard dose regimen of spironolactone and furosemide. The secondary objective is to determine the tolerability of different fixed doses of SR121463B over a 14 day treatment period in cirrhotic ascites.

NCT ID: NCT00501384 Completed - Liver Cirrhosis Clinical Trials

Satavaptan Dose-Ranging Study in the Prevention of Ascites

SPA
Start date: April 2004
Phase: Phase 2
Study type: Interventional

The primary objective is to determine the optimal dose or range of doses of SR121463B for the reduction in recurrence of ascites, when used concomitantly with a standard dose regimen of spironolactone. The secondary objective was to determine the tolerability of different fixed doses of SR121463B in cirrhotic ascites, over a 12-week treatment period. This SPA study is followed by a single-blind, placebo-controlled, 40 weeks long-term safety extension (ExSPA). The first extension is followed by another long-term study (PASCCAL-1).

NCT ID: NCT00501111 Completed - Alzheimer Disease Clinical Trials

Proof of Concept Study of Cognitive Improvement in Patients With Alzheimer's Disease

Sirocco
Start date: July 2007
Phase: Phase 2
Study type: Interventional

The purpose of this study is to demonstrate that AZD3480 improves cognition in patients with mild or moderate Alzheimer's disease, to assess the safety and tolerability of ZAD3480 and to define the optimal dose(s) to be used in future trials.