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NCT ID: NCT00510393 Completed - Clinical trials for Critical Limb Ischemia

Drug Eluting Stents In The Critically Ischemic Lower Leg

DESTINY
Start date: March 2008
Phase: Phase 2
Study type: Interventional

The Destiny trial compares the use of bare metal stent systems with drug eluting stent systems in the treatment of infrapopliteal lesions in patients with Critical Limb Ischemia. It will be investigated whether there is a difference in 12 month angiographic patency of the stented area using the 2 different stent systems.

NCT ID: NCT00510068 Completed - Clinical trials for Advanced Neuroendocrine Tumors of Pancreatic Origin

Efficacy and Safety of Everolimus (RAD001) Compared to Placebo in Patients With Advanced Neuroendocrine Tumors

RADIANT-3
Start date: July 2007
Phase: Phase 3
Study type: Interventional

The purpose of this study was to evaluate progression free survival in those participants assigned everolimus 10 mg/day plus Best Supportive Care versus those assigned to placebo plus Best Supportive Care in Advanced Neuroendocrine Tumors of pancreatic origin.

NCT ID: NCT00508924 Completed - Clinical trials for Coronary Artery Disease

Study on Safety and Effectiveness of Three Doses of Argatroban as Anticoagulant in Percutaneous Coronary Intervention (PCI)

Start date: August 2005
Phase: Phase 2
Study type: Interventional

This is a phase II multi-centre study in 140 patients undergoing elective PCI to obtain the information on dose-response of argatroban in pharmacodynamic markers and to assess the anticoagulation, safety and efficacy of argatroban in reference to unfractionated heparin, in combination with dual antiplatelet therapy.

NCT ID: NCT00508833 Completed - Hepatitis B Disease Clinical Trials

Safety and Efficacy of SmithKline Beecham (GlaxoSmithKline [GSK]) Biologicals' Candidate Adjuvanted Vaccines (287615)

Start date: March 2000
Phase: Phase 1/Phase 2
Study type: Interventional

This study was done to evaluate the effect of various adjuvants in combination with HBsAg as a model antigen on the induction of immune responses, mainly cytotoxic T lymphocytes (CTL) in healthy volunteers. The study was also done to evaluate the safety and reactogenicity of the various adjuvanted vaccines.

NCT ID: NCT00507455 Completed - Clinical trials for Lower Urinary Tract Symptoms

Solifenacin Succinate With Tamsulosin HCl in Males With Lower Urinary Tract Symptoms and Bladder Outlet Obstruction

Start date: June 2007
Phase: Phase 2
Study type: Interventional

A study to evaluate the safety of the co-administration of solifenacin succinate with tamsulosin hydrochloride in men with lower urinary tract symptoms (LUTS) and bladder outlet obstruction (BOO).

NCT ID: NCT00507091 Completed - Adenocarcinoma Clinical Trials

Phase I Irinotecan, 5-Fluorouracil and Leucovorin Combination

Start date: August 2005
Phase: Phase 1
Study type: Interventional

A Phase I open label study to asses the safety and tolerability of ZD6474 in combination with Irinotecan, 5-Fluorouracil and Leucovorin (FOLFIRI) as first or second line therapy in patients with metastatic colorectal adenocarcinoma.

NCT ID: NCT00506350 Completed - Influenza Clinical Trials

Evaluate Reactogenicity & Immunogenicity of an Influenza Pandemic Candidate Vaccine (GSK1562902A) in Primed Adults

Start date: August 1, 2007
Phase: Phase 2
Study type: Interventional

The present study is designed to evaluate the reactogenicity and immunogenicity of one or two booster administrations of an influenza pandemic candidate vaccine (GSK1562902A) in adults aged between 19 and 61 years, previously vaccinated with 2 doses of a pandemic candidate vaccine. Fifty new subjects who did not participate in a primary study (106750, NCT00309634) will be recruited. This protocol posting deals with objectives & outcome measures of the booster phase. The objectives & outcome measures of the primary phase are presented in a separate protocol posting (NCT00309634)

NCT ID: NCT00505934 Completed - Epilepsy Clinical Trials

Open-label Study of Levetiracetam Intravenous Infusion in Children (1 Month-4 Years Old) With Epilepsy

Start date: May 2008
Phase: Phase 2
Study type: Interventional

Keppra injection is approved in the US as adjunctive therapy in the treatment of partial onset seizures in adults with epilepsy. The objective of the current study is to assess the safety, tolerability, and pharmacokinetics, of this formulation in children aged 1 month to 4 years.

NCT ID: NCT00505388 Completed - Bronchial Asthma Clinical Trials

A Follow-up Programme for Patients Using Symbicort SMART in Normal Clinical Practice

Start date: July 2007
Phase:
Study type: Observational

This patient follow-up programme was designed to describe the extent of Symbicort use in patients prescribed Symbicort as maintenance and reliever therapy in routine clinical practice in comparison with the already documented use of Symbicort as maintenance and reliever therapy in clinical therapies

NCT ID: NCT00504959 Completed - Clinical trials for Subfoveal Choroidal Neovascularization (CNV)

Safety and Tolerability of Ranibizumab in Patients With Subfoveal Choroidal Neovascularization Secondary to Age-related Macular Degeneration

Start date: July 2007
Phase: Phase 4
Study type: Interventional

This extension study will investigate the long-term safety and tolerability of multiple intravitreal injections of ranibizumab administered to patients with subfoveal choroidal neovascularization secondary to age-related macular degeneration who have been previously treated in either of the two ongoing ranibizumab studies CRFB002A2302 (EXCITE) or CRFB002A2303 (SUSTAIN