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NCT ID: NCT00673556 Completed - Clinical trials for Chronic Plaque Psoriasis

A Study to Assess the Efficacy and Safety of Alefacept in Psoriasis Patients for Whom Conventional Treatment is Ineffective or Inappropriate

Start date: October 2003
Phase: Phase 3
Study type: Interventional

To assess the efficacy and safety of Alefacept compared to placebo for the treatment of Chronic Plaque Psoriasis in patients for whom conventional therapies are ineffective and inappropriate

NCT ID: NCT00673478 Completed - Clinical trials for Pulmonary Disease, Chronic Obstructive

Tiotropium and Salmeterol PK Study in COPD Patients

Start date: May 2008
Phase: Phase 3
Study type: Interventional

The primary objective of this study is to characterize the pharmacokinetics (i.e. systemic exposure to tiotropium and salmeterol) of tiotropium qd + salmeterol qd or bid versus tiotropium qd and salmeterol bid following 4-week treatment periods in patients with chronic obstructive pulmonary disease (COPD).

NCT ID: NCT00673205 Completed - Clinical trials for Non-Metastatic Prostate Cancer

(Bicalutamide) Casodex vs Placebo in Non-metastatic Early Prostate Cancer

Capri
Start date: September 1995
Phase: Phase 3
Study type: Interventional

The purpose of this trial is to study the effect of adjuvant or immediate hormonal therapy, versus placebo, in subjects who have either undergone a primary therapy (principally radical prostatectomy or radiotherapy) or who were otherwise to be managed by watchful waiting.

NCT ID: NCT00672477 Completed - Clinical trials for Opioid-Induced Constipation

Study Evaluating Subcutaneous Methylnaltrexone For Treatment Of Opioid-Induced Constipation In Patients With Advanced Illness

Start date: June 2008
Phase: Phase 4
Study type: Interventional

This study will evaluate the safety and efficacy of methylnaltrexone administered as subcutaneous injections in subjects who have opioid-induced constipation and an advanced illness. The hypothesis is that methylnaltrexone will be safe and effective in relieving opioid-induced constipation in these subjects.

NCT ID: NCT00672386 Completed - Clinical trials for Diabetes Mellitus, Type 2

A Study of the Safety and Effectiveness of a R256918 in Patients With Type 2 Diabetes

Start date: December 2007
Phase: Phase 2
Study type: Interventional

The purpose of this study is to investigate the effectiveness and safety of 12 weeks of treatment with R256918 in patients with Type 2 Diabetes Mellitus who are taking metformin. The primary measure of effectiveness is the change in concentration of glycated hemoglobin (HbA1c) during treatment. Glycated hemoglobin is a substance in red blood cells that is formed when blood sugar (glucose) attaches to hemoglobin and is a measure of diabetic status. Additional measures include fasting glucose, and lipid levels, and body weight. Safety assessments performed during the trial include laboratory tests, vital sign measurements, and adverse event reporting.

NCT ID: NCT00672139 Completed - Clinical trials for Opioid-Induced Constipation

Safety of Subcutaneous Methylnaltrexone for Opioid-Induced Constipation in Patients With Advanced Illness

Start date: July 2008
Phase: Phase 4
Study type: Interventional

This is an open-label, multicenter extension of study 3200K1-4000-WW that will evaluate the safety of methylnaltrexone. This drug will be administered by subcutaneous injection and will be tested in late stage, advanced illness patients who have constipation caused by opioid pain relievers. This study will last 3 months.

NCT ID: NCT00670670 Completed - Clinical trials for Early Caries Lesions

A Prospective, Randomized Clinical Study on the Effects of Casein Phosphopeptide-amorphous Calcium Phosphate (CPP-ACP) Paste on Plaque, Gingivitis and White Spot Lesions in Orthodontic Patients - Part 1

Start date: October 1, 2008
Phase: N/A
Study type: Interventional

Influence of CPP-ACP paste on the evolution and appearance of white spot lesions in orthodontic patients after removal of the fixed appliances.

NCT ID: NCT00670618 Completed - Clinical trials for Early Caries Lesions

A Prospective, Randomized Clinical Study on the Effects of Casein Phosphopeptide-amorphous Calcium Phosphate (CPP-ACP) Paste on Plaque, Gingivitis and White Spot Lesions in Orthodontic Patients - Part 2

Start date: October 1, 2008
Phase: N/A
Study type: Interventional

Influence of CPP-ACP paste and Elmex Medical Gel on the prevention of white spot lesions in orthodontic patients during fixed appliances.

NCT ID: NCT00670592 Completed - Clinical trials for Non-Hodgkin's Lymphoma

Study of HCD122 in Adults With Non-Hodgkin's or Hodgkin's Lymphoma Who Have Progressed After at Least Two Prior Therapies

Start date: March 2008
Phase: Phase 1/Phase 2
Study type: Interventional

This study is to evaluate the highest tolerated dose, safety and activity of HCD122 in adults with non-Hodgkin's or Hodgkin's lymphoma who have received at least two prior therapies.

NCT ID: NCT00670553 Completed - Prostate Cancer Clinical Trials

A Phase I Study of LBH589 (Panobinostat) in Combination With External Beam Radiotherapy for the Treatment of Prostate Cancer, Esophageal Cancer and Head and Neck Cancer

Start date: September 2008
Phase: Phase 1
Study type: Interventional

The purpose of this study is to assess the feasibility of combined administration of different LBH589 dosages with radiotherapy in order to establish the dosage to be evaluated in future studies.