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NCT ID: NCT00718692 Completed - Clinical trials for Immune Thrombocytopenic Purpura

Open Label Trial on the Safety and Efficacy of Sym001 in the Treatment of Immune Thrombocytopenic Purpura (ITP)

Start date: July 2008
Phase: Phase 2
Study type: Interventional

This trial is designed as a multi-centre, single-dose, exploratory dose-finding, open label trial evaluating the safety and efficacy of Sym001 in 4-9 consecutive cohorts. Subjects will receive a single IV dose of Sym001.

NCT ID: NCT00717834 Completed - Clinical trials for Ross River Virus Disease (RRVD)

Safety and Immunogenicity Study of a Ross River Virus (RRV) Vaccine

Start date: June 2008
Phase: Phase 1/Phase 2
Study type: Interventional

The primary objective of this study is to assess the safety and tolerability of the Ross River Virus (RRV) Vaccine in a healthy young adult population. Other objectives of this study are to assess the immunogenicity of the RRV Vaccine in a healthy young adult population and to identify the optimal dose level of the RRV Vaccine in a healthy young adult population.

NCT ID: NCT00717470 Completed - Clinical trials for Kidney Transplantation

A Study in Kidney Transplant Subjects to Investigate the Optimal Suppression of Immunity to Help Prevent Kidney Rejection

OSAKA
Start date: May 14, 2008
Phase: Phase 4
Study type: Interventional

To compare how well the new formulation of Tacrolimus® used once daily, in combination with other drugs helps prevent the rejection of a new kidney after transplantation compared to the twice daily dose of Tacrolimus

NCT ID: NCT00717366 Completed - Anemia Clinical Trials

A Study of Intravenous Mircera for the Treatment of Anemia in Pediatric Patients on Hemodialysis

Start date: July 2008
Phase: Phase 2
Study type: Interventional

This sequential study will assess the efficacy and safety of multiple doses of intravenous Mircera, and will determine the optimum starting dose for maintenance treatment of anemia in children with chronic kidney disease on hemodialysis. Pediatric patients will remain on epoetin alfa, epoetin beta or darbepoetin alfa during the screening period, after which they will receive intravenous Mircera monthly, at a starting dose related to the previous weekly epoetin or darbepoetin alfa dose. Depending on the response achieved, another group may be selected to receive a higher or a lower dose. The anticipated time on study treatment is 3-12 months, and the target sample size is <100 individuals.

NCT ID: NCT00716859 Completed - Glaucoma Clinical Trials

A Phase 3 Prospective, Randomized, Double-Masked, 12-Week, Parallel Group Study In Pediatric Subjects With Glaucoma.

Start date: July 2008
Phase: Phase 3
Study type: Interventional

To assess the effectiveness of latanoprost 0.005% ophthalmic solution dosed once-daily and timolol 0.5% dosed twice-daily in paediatric subjects of 18 years of age or under who are diagnosed with glaucoma.

NCT ID: NCT00716417 Completed - Neoplasms Clinical Trials

Study to Determine the Maximum Tolerated Dose of BIBW 2992 (Afatinib) When Combined With Cisplatin/Paclitaxel or Cisplatin/5-FU in Patients With Advanced Solid Tumours

Start date: July 2008
Phase: Phase 1
Study type: Interventional

Study to determine the maximum tolerated dose of BIBW 2992 when combined with backbone chemotherapies consisting in cisplatin plus paclitaxel or cisplatin plus 5 FU. The overall safety, the pharmacokinetics and the anti-tumour efficacy will also be assessed.

NCT ID: NCT00716079 Completed - Stroke Clinical Trials

The Second Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial

INTERACT2
Start date: September 2008
Phase: N/A
Study type: Interventional

The purpose of this academic lead study is to determine if a treatment strategy of early intensive blood pressure (BP) lowering compared to conservative BP lowering policy in patients with elevated blood pressure within 6 hours of acute intracerebral haemorrhage (ICH) improves the outcome of death and disability at 3 months after onset.

NCT ID: NCT00714961 Completed - Clinical trials for Acute Coronary Syndromes

Clopidogrel as Adjunctive Reperfusion Therapy - Thrombolysis in Myocardial Infarction

CLARITY-TIMI28
Start date: February 2003
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine if the combination of aspirin plus clopidogrel is more effective than aspirin alone in preventing another heart attack, chest pain, stroke or death in people who have already had a heart attack that was treated with fibrinolytic therapy.

NCT ID: NCT00714688 Completed - Clinical trials for Attention Deficit/ Hyperactivity Disorder

A Study to Evaluate Effectiveness and Safety of Prolonged Release OROS Methylphenidate in Adults With Attention Deficit Hyperactivity Disorder

Start date: February 2008
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the efficacy of 2 fixed dosages of Prolonged Release (PR) OROS methylphenidate (54 and 72 mg/day) compared with placebo in adult patients with attention deficit/hyperactivity disorder (ADHD).

NCT ID: NCT00714649 Completed - Clinical trials for Head and Neck Cancer

Neoadjuvant Cetuximab in HNSCC Combined With Curative Surgery

CHIRON
Start date: July 2008
Phase: Phase 1/Phase 2
Study type: Interventional

Primary diagnose HNSCC carcinoma patients eligible for curative surgery will be proposed the addition of 2 or 3 neoadjuvant cetuximab infusions. The main objective is to reduce to a minimal delay the time elapsing between last infusion and surgery. Iterative biomarkers will be taken at 6 time points permitting to investigate expression gen profile and protein mutation.