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NCT ID: NCT00925067 Completed - Inguinal Hernia Clinical Trials

Effects of Lightweight Meshes in Laparoscopic Inguinal Hernia Repair on Quality of Life and Male Fertility Aspects

Start date: April 2003
Phase: N/A
Study type: Interventional

A randomized, prospective clinical trial analyzing whether the use of lightweight prostheses during laparoscopic inguinal hernia repair of male patients could have a beneficial effect on postoperative discomfort, chronic pain development, recurrence and male fertility aspects.

NCT ID: NCT00924638 Completed - Clinical trials for Cryptogenic Ischemic Stroke

Study of Continuous Cardiac Monitoring to Assess Atrial Fibrillation After Cryptogenic Stroke

CRYSTAL-AF
Start date: June 2009
Phase: Phase 4
Study type: Interventional

The 2006 American Heart Association / American Stroke Association Council on Stroke Guidelines for Prevention of Stroke in Patients With Ischemic Stroke or Transient Ischemic recommended that patients with cryptogenic stroke take antithrombotic drugs (i.e. aspirin) in order to prevent a second stroke. When a stroke patient is found to have atrial fibrillation (AF), the guidelines recommend oral anticoagulation due to its superior efficacy over aspirin for stroke prevention. Physicians can best optimize the use of medicines only if they can precisely and correctly diagnose a patient's AF. The purpose of this study is to evaluate the time to first AF by 6 months' continuous rhythm monitoring versus control treatment in subjects with a recent cryptogenic stroke or Transient Ischemic Attack (TIA) without history of AF.

NCT ID: NCT00923091 Completed - Clinical trials for Essential Hypertension

Parallel-Group Comparison of Olmesartan (OLM), Amlodipine (AML) and Hydrochlorothiazid (HCTZ) in Hypertension

Start date: June 2009
Phase: Phase 3
Study type: Interventional

This study is to determine the change in blood pressure from the administration of Olmesartan/Amlodipine/Hydrochlorothiazide triple combinations compared to dual combinations with Olmesartan/Amlodipine.

NCT ID: NCT00922181 Completed - Liver Neoplasms Clinical Trials

Single-probe Microwave Ablation (MWA) of Metastatic Liver Cancer

LiverMWA1
Start date: August 2008
Phase: N/A
Study type: Interventional

Microwave ablation (MWA) is the most recent development in the field of local ablative therapies. The aim of this study was to evaluate the variability and reproducibility of single-probe MWA versus radiofrequency ablation (RFA) of metastatic liver tumours smaller than 3 cm in patients without underlying liver disease.

NCT ID: NCT00921193 Completed - Prostate Cancer Clinical Trials

Evaluation of Radiation Therapy Positioning System (RTPS) in Patients With Localized Prostate Cancer

Start date: May 2009
Phase: N/A
Study type: Interventional

The study aims to evaluate the safety and performance of the RTPS in patients with localized prostate cancer.The RTPS is an investigational device and requires permanent implantation of a small radioactive fiducial, called the Blip, in the prostate.

NCT ID: NCT00920140 Completed - Cancer Clinical Trials

Open-label Study to Evaluate the Safety, PK, and PD of MEK Inhibitor GSK1120212 in Subjects With Relapsed or Refractory Leukemias

Start date: May 2011
Phase: Phase 2
Study type: Interventional

MEK111759 is a dose-escalation, Phase I/II, open-label study to determine the recommended dose and regimen for the orally administered MEK inhibitor GSK1120212 in subjects with relapsed or refractory leukemias. The recommended dose and regimen will be selected based on the safety, pharmacokinetic, and pharmacodynamic profiles. This study will identify the maximum tolerated and recommended Phase II doses using a dose-escalation procedure. Dose escalations will continue based on predefined parameters until a maximum tolerated dose is established. In Phase II, the clinical efficacy of GSK1120212 in subjects with relapsed or refractory leukaemias (AML, MDS or CMML) will be determined.

NCT ID: NCT00918632 Completed - Healthy Volunteers Clinical Trials

Food Effect Study Of AG-013736 In Healthy Volunteers

Start date: June 2009
Phase: Phase 1
Study type: Interventional

The study is designed to evaluate the effect of food on typical blood levels obtained after oral dosing of AG-013736. Drug levels in blood will be compared after an overnight fast and a high-fat, high-calorie meal.

NCT ID: NCT00918476 Completed - Hepatitis C Clinical Trials

Investigation Of The Effect Of Steady State Filibuvir On The Pharmacokinetics Of Oral Contraceptives (Levonorgestrel And Ethinyl Estradiol)

Start date: June 2010
Phase: Phase 1
Study type: Interventional

The purpose of this study is to estimate the effect of filibuvir on the pharmacokinetics of ethinyloestradiol [EE] and levonorgestrel [LN], to assess the safety and tolerability of 600 mg BID of filibuvir in healthy women and to investigate the pharmacokinetics of 600 mg BID of filibuvir in healthy women.

NCT ID: NCT00917176 Completed - Fibromyalgia Clinical Trials

Occipital Nerve Stimulation in Fibromyalgia

Start date: n/a
Phase: Phase 2
Study type: Interventional

The aim of this study is to investigate whether greater occipital nerve stimulation is effective in the treatment of fibromyalgia related pain. The study uses sub sensory threshold stimulation and placebo stimulation in order to investigate whether sub-threshold stimulation is feasible in a placebo controlled study.

NCT ID: NCT00917046 Completed - Heart Failure Clinical Trials

The SMARTEX Heart Failure Study

SMARTEX
Start date: January 2009
Phase: N/A
Study type: Interventional

This protocol describes a randomized multicenter clinical trial designed to test the hypothesis that a 12-week program of high-intensity interval training (HIIT) yields larger beneficial effects in stable heart failure patients than current practice, defined as either a similar training program with the same volume of moderate continuous training (MCT) or a recommendation of regular exercise at moderate intensity at individual choice (RRE).