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NCT ID: NCT02792231 Completed - Clinical trials for Relapsing Multiple Scelrosis

Efficacy and Safety of Ofatumumab Compared to Teriflunomide in Patients With Relapsing Multiple Sclerosis.

ASCLEPIOS II
Start date: August 26, 2016
Phase: Phase 3
Study type: Interventional

To compare the efficacy and safety of ofatumumab administered subcutaneously (sc) every 4 weeks versus teriflunomide administered orally once daily in patients with relapsing multiple sclerosis

NCT ID: NCT02792218 Completed - Clinical trials for Relapsing Multiple Sclerosis

Efficacy and Safety of Ofatumumab Compared to Teriflunomide in Patients With Relapsing Multiple Sclerosis

ASCLEPIOS I
Start date: September 20, 2016
Phase: Phase 3
Study type: Interventional

To compare the efficacy and safety of ofatumumab administered subcutaneously (sc) every 4 weeks versus teriflunomide administered orally once daily in patients with relapsing multiple sclerosis

NCT ID: NCT02791230 Completed - Clinical trials for Transthyretin (TTR) Amyloid Cardiomyopathy

Long-term Safety of Tafamidis in Subjects With Transthyretin Cardiomyopathy

Start date: June 13, 2016
Phase: Phase 3
Study type: Interventional

Open label study to evaluate tafamidis for the treatment of transthyretin cardiomyopathy

NCT ID: NCT02790138 Completed - Pouchitis Clinical Trials

A Study to Evaluate the Efficacy and Safety of Vedolizumab in the Treatment of Chronic Pouchitis

EARNEST
Start date: October 12, 2016
Phase: Phase 4
Study type: Interventional

The purpose of this study is to compare the efficacy of vedolizumab intravenous (IV) and placebo in terms of the percentage of participants with chronic or recurrent pouchitis achieving clinically relevant remission.

NCT ID: NCT02789293 Completed - Glaucoma Clinical Trials

Glaucoma Treatment Using Focused Ultrasound in Open Angle Glaucoma Patients

Start date: May 2016
Phase: N/A
Study type: Interventional

The purpose of the this study is to collect safety and efficacy data on Focused Ultrasound treatment (UCP procedure) in open angle glaucoma patients without previous glaucoma surgery.

NCT ID: NCT02788721 Completed - Healthy Clinical Trials

A Study to Assess Safety, Tolerability and Pharmacokinetics of GLPG2451 in Healthy Female Subjects

Start date: April 14, 2016
Phase: Phase 1
Study type: Interventional

The study is a First-in-Human, Phase I, randomized, double-blind, placebo-controlled study evaluating single and multiple ascending oral doses of GLPG2451 and combined multiple doses of GLPG2451 and GLPG2222 in healthy female subjects. The purpose of the study is to evaluate safety and tolerability after single ascending oral doses and of multiple doses of GLPG2451 given to healthy female subjects compared to placebo as well as of multiple doses of the combination of GLPG2451/GLPG2222 compared to GLPG2451/placebo.

NCT ID: NCT02788474 Completed - Clinical trials for Idiopathic Pulmonary Fibrosis

Effect of Nintedanib on Biomarkers of Extracellular Matrix Turnover in Patients With Idiopathic Pulmonary Fibrosis and Limited Forced Vital Capacity Impairment

Start date: June 9, 2016
Phase: Phase 4
Study type: Interventional

Identifying biomarkers to predict the clinical course and benefits of therapy early in the course of the disease remains one of the most urgent and relevant challenges to improve overall patient management, to prevent treatment delay or overtreatment. This study is conducted to examine the effect of nintedanib treatment on change in biomarkers indicative of extracellular matrix turnover which have been shown recently to correlate with disease progression. This study further aims to confirm the association of biomarker course during the first three months of treatment and disease progression.

NCT ID: NCT02788279 Completed - Colorectal Cancer Clinical Trials

A Study to Investigate Efficacy and Safety of Cobimetinib Plus Atezolizumab and Atezolizumab Monotherapy Versus Regorafenib in Participants With Metastatic Colorectal Adenocarcinoma (COTEZO IMblaze370)

Start date: July 5, 2016
Phase: Phase 3
Study type: Interventional

This is a Phase III, multicenter, open-label, three-arm, randomized study in participants with unresectable locally advanced or metastatic colorectal cancer (CRC) who have received at least two prior regimens of cytotoxic chemotherapy for metastatic disease. The study compares regorafenib, a standard of care therapy in this setting, to cobimetinib plus atezolizumab and atezolizumab monotherapy.

NCT ID: NCT02787265 Completed - Clinical trials for Failed Back Surgery Syndrome

High-density in Spinal Cord Stimulation: Virtual Expert Registry

Discover
Start date: June 2016
Phase:
Study type: Observational [Patient Registry]

This is a prospective, multi-center, observational follow-up study observing the effectiveness of high density spinal cord stimulation in patients with failed back surgery syndrome patients with back and leg pain.

NCT ID: NCT02787252 Completed - FBSS Clinical Trials

Stimwave HF SCS Pilot Study

HFSCS
Start date: June 2016
Phase: N/A
Study type: Interventional

The purpose of this study is to observe the efficacy of stimulation on over all pain relief as reported in an initial cohort of 6 patients treated with the Freedom High Frequency Spinal Cord Stimulator (SCS) System for low back and/or leg pain.