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NCT ID: NCT01377831 Completed - Pain Clinical Trials

Study of Ketamine Administered Intravenously and by Sublingual Wafer

Start date: June 2011
Phase: N/A
Study type: Observational

To determine the rate and extent of of absorption of racemic ketamine from sublingual wafer

NCT ID: NCT01376804 Completed - Clinical trials for Kidney Transplantation, Cytomegalovirus Infections

A Study of Oral Valcyte (Valganciclovir) in Pediatric Kidney Transplant Recipients

Start date: July 2011
Phase: Phase 4
Study type: Interventional

This open-label, single arm study will evaluate the tolerability and efficacy of Valcyte (valganciclovir) in the prevention of cytomegalovirus disease in pediatric renal transplant recipients. After transplantation, patients (aged 4 months to 16 years) will receive Valcyte orally daily for up to 200 days post-transplant and will be followed for 52 weeks post-transplantation.

NCT ID: NCT01375777 Completed - Hyperlipidemia Clinical Trials

Monoclonal Antibody Against PCSK9 to Reduce Elevated Low-density Lipoprotein Cholesterol (LDL-C) in Adults Currently Not Receiving Drug Therapy for Easing Lipid Levels

MENDEL
Start date: July 6, 2011
Phase: Phase 2
Study type: Interventional

The primary objective was to evaluate the effect of 12 weeks of subcutaneous evolocumab (AMG 145) every 2 weeks (Q2W) or every 4 weeks (Q4W), compared with placebo, on the percent change from baseline in LDL-C when used as monotherapy in adults with hypercholesterolemia.

NCT ID: NCT01375764 Completed - Hyperlipidemia Clinical Trials

Goal Achievement After Utilizing an Anti-PCSK9 Antibody in Statin Intolerant Subjects

GAUSS
Start date: July 28, 2011
Phase: Phase 2
Study type: Interventional

The primary objective was to evaluate the effect of 12 weeks of subcutaneous evolocumab (AMG 145), compared with ezetimibe, on percent change from baseline in low-density lipoprotein cholesterol (LDL-C) in patients with hypercholesterolemia unable to tolerate an effective dose of a statin.

NCT ID: NCT01375127 Completed - Clinical trials for Kidney Transplantation

Collection of Follow-up Data From CP-690,550-treated Kidney Transplant Recipients

Start date: August 2011
Phase: N/A
Study type: Observational

This is an observational study designed to collect follow-up clinical date on subjects who were treated with tofacitinib in 2 completed Phase 2 studies who either discontinued treatment prematurely or did not elect to enroll in long-term extension studies.

NCT ID: NCT01374451 Completed - Islet Cell Tumor Clinical Trials

Efficacy of Everolimus Alone or in Combination With Pasireotide LAR in Advanced PNET

COOPERATE-1
Start date: June 2011
Phase: Phase 2
Study type: Interventional

This study will estimate the treatment effect of everolimus in combination with pasireotide LAR relative to everolimus alone on progression-free survival (PFS) in patients with advanced progressive PNET

NCT ID: NCT01373424 Completed - Dystonia Clinical Trials

The Dystonia Coalition Natural History and Biospecimen Repository for Isolated Dystonias

DCP
Start date: January 2011
Phase:
Study type: Observational

Dystonia is a disorder characterized by excessive involuntary contraction of muscles with repetitive and patterned movements. The isolated dystonias are the most common type of dystonia and include Limb dystonias (like writer's cramp), Cervical dystonia (spasmodic torticollis), Laryngeal dystonias (like spasmodic dysphonia), and Craniofacial dystonias (like blepharospasm). The purpose of this study is to create resources to help learn more about the isolated dystonias, myoclonus dystonia, and dopa-responsive dystonia and to develop and validate various dystonia rating scales.

NCT ID: NCT01372761 Completed - Obesity Clinical Trials

Pharmacokinetics, Safety, Tolerability and Efficacy of Intravenous Doses of ZGN-433 in Obese Female Volunteers

Start date: June 2011
Phase: Phase 1
Study type: Interventional

The purpose of this study is to assess whether multiple doses of ZGN-433 are safe and effective.

NCT ID: NCT01372696 Withdrawn - Colon Cancer Clinical Trials

Endoscopic Characteristics of Colonic Tumours

C-LST
Start date: November 2009
Phase: N/A
Study type: Interventional

The purpose is to investigate whether polyps that look different at colonoscopy, have formed via different mutations and have different risks of turning into cancer.

NCT ID: NCT01371981 Active, not recruiting - Clinical trials for Acute Myeloid Leukemia

Bortezomib and Sorafenib Tosylate in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia

Start date: June 20, 2011
Phase: Phase 3
Study type: Interventional

This randomized phase III trial studies how well bortezomib and sorafenib tosylate work in treating patients with newly diagnosed acute myeloid leukemia. Bortezomib and sorafenib tosylate may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving bortezomib and sorafenib tosylate together with combination chemotherapy may be an effective treatment for acute myeloid leukemia.